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1.Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases 失效
标题翻译: 吡咯并[2,1-f] [1,2,4]三嗪-4-基胺治疗癌症和其他过度增生性疾病的IGF-1R激酶抑制剂公开(公告)号:US08431695B2
公开(公告)日:2013-04-30
申请号:US12084411
申请日:2006-11-02
申请人: Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
发明人: Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
IPC分类号: C07D487/04 , C07D413/02 , C07D417/02 , A61K31/53 , A61P35/00
CPC分类号: C07D487/04
摘要: This invention relates to novel compounds of formula (I). Formula (I) in which the variable groups are as defined in the specification and claims, to pharmaceutical compositions containing them, and to a method of treatment using them for treatment of cancer.
摘要翻译: 本发明涉及新的式(I)化合物。 式(I)其中可变基团如说明书和权利要求中所定义,含有它们的药物组合物,以及使用它们治疗癌症的方法。
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2.Pyrrolo[2,1-F] [1,2,4] Triazin-4-Ylamines IGF-1R Kinase Inhibitors for the Treatment of Cancer and Other Hyperproliferative Diseases 失效
标题翻译: 吡咯并[2,1-F] [1,2,4]三嗪-4-基胺IGF-1R激酶抑制剂治疗癌症和其他过度增生性疾病公开(公告)号:US20110294776A1
公开(公告)日:2011-12-01
申请号:US12084411
申请日:2006-11-02
申请人: Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
发明人: Stephen O'Connor , Jacques Dumas , Wendy Lee , Julie Dixon , David Cantin , David Gunn , Jennifer Burke , Barton Phillips , Derek Lowe , Tatiana Shelekhin , Gan Wang , Xin Ma , Shihong Ying , Andrea McClure , Furahi Achebe , Mario Lobell , Frederick Ehrgott , Christiana Iwuagwu , Kyle Parcella
IPC分类号: A61K31/53 , C07D498/04 , A61P35/00 , A61K31/5383 , A61K31/541 , A61K31/55 , C07D487/04 , A61K31/5377
CPC分类号: C07D487/04
摘要: This invention relates to novel compounds of formula (I). Formula (I) in which the variable groups are as defined in the specification and claims, to pharmaceutical compositions containing them, and to a method of treatment using them for treatment of cancer.
摘要翻译: 本发明涉及新的式(I)化合物。 式(I)其中可变基团如说明书和权利要求中所定义,含有它们的药物组合物,以及使用它们治疗癌症的方法。
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3.
公开(公告)号:US20050256167A1
公开(公告)日:2005-11-17
申请号:US11133751
申请日:2005-05-20
申请人: Roger Smith , Stephen O'Connor , Stephan-Nicholas Wirtz , Wai Wong , Soongyu Choi , Harold Kluender , Ning Su , Gan Wang , Furahi Achebe , Shihong Ying
发明人: Roger Smith , Stephen O'Connor , Stephan-Nicholas Wirtz , Wai Wong , Soongyu Choi , Harold Kluender , Ning Su , Gan Wang , Furahi Achebe , Shihong Ying
IPC分类号: A61K31/4164 , A61K31/4196 , A61K31/42 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P15/00 , A61P19/02 , A61P25/00 , A61P25/28 , A61P25/30 , A61P35/00 , C07D233/90 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/08 , C07D417/14 , A61K31/4172 , C07D43/02
CPC分类号: C07D401/06 , C07D233/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/06 , C07D409/14
摘要: This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.
摘要翻译: 本发明涉及已被发现抑制食欲并引起体重减轻的取代的咪唑衍生物。 本发明还提供了合成化合物的方法,包含该化合物的药物组合物,以及使用这些组合物诱导体重减轻和治疗肥胖症和肥胖相关疾病的方法。
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4.
公开(公告)号:US20080214545A1
公开(公告)日:2008-09-04
申请号:US11579093
申请日:2005-05-02
申请人: Wendy Lee , Gaetan Ladouceur , Jacques Dumas , Roger Smith , Shihong Ying , Gan Wang , Zhi Chen , Qingjie Liu , Holia Hatoum Mokdad
发明人: Wendy Lee , Gaetan Ladouceur , Jacques Dumas , Roger Smith , Shihong Ying , Gan Wang , Zhi Chen , Qingjie Liu , Holia Hatoum Mokdad
IPC分类号: A61K31/5377 , C07D401/12 , C07D413/14 , A61P35/02 , A61P35/00 , A61K31/4439
CPC分类号: C07D401/12 , C07D405/14
摘要: The present invention relates to compounds of formula (I), pharmaceutical compositions which contain them and methods for treating cancer using compounds of formula (I).
摘要翻译: 本发明涉及式(I)化合物,含有它们的药物组合物和使用式(I)化合物治疗癌症的方法。
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5.
公开(公告)号:US08207166B2
公开(公告)日:2012-06-26
申请号:US12941841
申请日:2010-11-08
申请人: Wendy Lee , Gaetan Ladouceur , Jacques Dumas , Roger Smith , Shihong Ying , Gan Wang , Zhi Chen , Qingjie Liu , Holia Mokdad
发明人: Wendy Lee , Gaetan Ladouceur , Jacques Dumas , Roger Smith , Shihong Ying , Gan Wang , Zhi Chen , Qingjie Liu , Holia Mokdad
IPC分类号: A61K31/5377 , A61K31/4439 , A61K31/454 , A61K31/497
CPC分类号: C07D401/12 , C07D405/14
摘要: The present invention relates to compounds of formula (I), pharmaceutical compositions which contain them and methods for treating cancer using compounds of formula (I).
摘要翻译: 本发明涉及式(I)化合物,含有它们的药物组合物和使用式(I)化合物治疗癌症的方法。
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6.
公开(公告)号:US07838524B2
公开(公告)日:2010-11-23
申请号:US11579093
申请日:2005-05-02
申请人: Wendy Lee , Gaetan Ladouceur , Jacques Dumas , Roger Smith , Shihong Ying , Gan Wang , Zhi Chen , Qingjie Liu , Holia Hatoum Mokdad
发明人: Wendy Lee , Gaetan Ladouceur , Jacques Dumas , Roger Smith , Shihong Ying , Gan Wang , Zhi Chen , Qingjie Liu , Holia Hatoum Mokdad
IPC分类号: A61K31/4439 , A61K31/5377 , A61K31/497 , A61K31/454 , C07D401/14 , C07D413/14
CPC分类号: C07D401/12 , C07D405/14
摘要: The present invention relates to compounds of formula (I), pharmaceutical compositions which contain them and methods for treating cancer using compounds of formula (I).
摘要翻译: 本发明涉及式(I)化合物,含有它们的药物组合物和使用式(I)化合物治疗癌症的方法。
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公开(公告)号:US06960601B2
公开(公告)日:2005-11-01
申请号:US10255049
申请日:2002-09-24
申请人: Roger A. Smith , Stephen J. O'Connor , Stephan-Nicholas Wirtz , Wai C. Wong , Soongyu Choi , Harold C. E. Kluender , Ning Su , Gan Wang , Furahi Achebe , Shihong Ying
发明人: Roger A. Smith , Stephen J. O'Connor , Stephan-Nicholas Wirtz , Wai C. Wong , Soongyu Choi , Harold C. E. Kluender , Ning Su , Gan Wang , Furahi Achebe , Shihong Ying
IPC分类号: A61K31/4164 , A61K31/4196 , A61K31/42 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P15/00 , A61P19/02 , A61P25/00 , A61P25/28 , A61P25/30 , A61P35/00 , C07D233/90 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/08 , C07D417/14 , A61K31/445
CPC分类号: C07D401/06 , C07D233/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/06 , C07D409/14
摘要: This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.
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