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    Microfludic protein crystallography techniques
    1.
    发明授权
    Microfludic protein crystallography techniques 失效
    微氟蛋白晶体学技术

    公开(公告)号：US08709153B2

    公开(公告)日：2014-04-29

    申请号：US13280276

    申请日：2011-10-24

    申请人： Carl L. Hansen ,  Stephen R. Quake ,  James M. Berger

    发明人： Carl L. Hansen ,  Stephen R. Quake ,  James M. Berger

    IPC分类号： C30B7/14

    CPC分类号： C30B7/14 ,  F17D5/005 ,  F17D5/06 ,  Y10T137/0318 ,  Y10T137/0391

    摘要： The present invention relates to microfluidic devices and methods facilitating the growth and analysis of crystallized materials such as proteins. In accordance with one embodiment, a crystal growth architecture is separated by a permeable membrane from an adjacent well having a much larger volume. The well may be configured to contain a fluid having an identity and concentration similar to the solvent and crystallizing agent employed in crystal growth, with diffusion across the membrane stabilizing that process. Alternatively, the well may be configured to contain a fluid having an identity calculated to affect the crystallization process. In accordance with the still other embodiment, the well may be configured to contain a material such as a cryo-protectant, which is useful in protecting the crystalline material once formed.

    摘要翻译： 本发明涉及促进结晶物质如蛋白质生长和分析的微流体装置和方法。 根据一个实施例，晶体生长结构由具有大得多体积的相邻阱的可渗透膜分离。 该孔可以被配置成包含具有与晶体生长中使用的溶剂和结晶剂相似的特性和浓度的流体，并且通过膜的扩散稳定了该过程。 或者，孔可以被配置为包含具有计算以影响结晶过程的同一性的流体。 根据另一个实施方案，所述孔可以被配置为容纳诸如冷冻保护剂的材料，其可用于在形成后保护结晶材料。

    Microfluidic Protein Crystallography Techniques
    6.
    发明申请
    Microfluidic Protein Crystallography Techniques 失效
    微流体蛋白晶体学技术

    公开(公告)号：US20120241015A1

    公开(公告)日：2012-09-27

    申请号：US13280276

    申请日：2011-10-24

    申请人： Carl L. Hansen ,  Stephen R. Quake ,  James M. Berger

    发明人： Carl L. Hansen ,  Stephen R. Quake ,  James M. Berger

    IPC分类号： F17D1/00

    CPC分类号： C30B7/14 ,  F17D5/005 ,  F17D5/06 ,  Y10T137/0318 ,  Y10T137/0391

    摘要： The present invention relates to microfluidic devices and methods facilitating the growth and analysis of crystallized materials such as proteins. In accordance with one embodiment, a crystal growth architecture is separated by a permeable membrane from an adjacent well having a much larger volume. The well may be configured to contain a fluid having an identity and concentration similar to the solvent and crystallizing agent employed in crystal growth, with diffusion across the membrane stabilizing that process. Alternatively, the well may be configured to contain a fluid having an identity calculated to affect the crystallization process. In accordance with the still other embodiment, the well may be configured to contain a material such as a cryo-protectant, which is useful in protecting the crystalline material once formed.

    摘要翻译： 本发明涉及促进结晶物质如蛋白质生长和分析的微流体装置和方法。 根据一个实施例，晶体生长结构由具有大得多体积的相邻阱的可渗透膜分离。 该孔可以被配置成包含具有与晶体生长中使用的溶剂和结晶剂相似的特性和浓度的流体，并且通过膜的扩散稳定了该过程。 或者，孔可以被配置为包含具有计算以影响结晶过程的同一性的流体。 根据另一个实施方案，所述孔可以被配置为容纳诸如冷冻保护剂的材料，其可用于在形成后保护结晶材料。