Salts and polymorphs of a pyrrole-substituted indolinone compound
    3.
    发明授权
    Salts and polymorphs of a pyrrole-substituted indolinone compound 失效
    吡咯取代的吲哚啉酮化合物的盐和多晶型物

    公开(公告)号:US07247627B2

    公开(公告)日:2007-07-24

    申请号:US10956420

    申请日:2004-09-30

    IPC分类号: A61K31/5377 C07D413/14

    CPC分类号: C07D403/06

    摘要: The invention relates to non-hygroscopic salts of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, such as maleate salts, and to crystalline polymorphs of these salts. The invention further relates to pharmaceutical compositions of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide salts, and methods of treating disorders such as cancer using such compositions.

    摘要翻译: 本发明涉及5 - [(Z) - (5-氟-2-氧代-1,2-二氢-3H-吲哚-3-亚基)甲基] -N - [(2S)-2 - 羟基-3-吗啉-4-基丙基] -2,4-二甲基-1H-吡咯-3-甲酰胺,例如马来酸盐,以及这些盐的结晶多晶型物。 本发明还涉及5 - [(Z) - (5-氟-2-氧代-1,2-二氢-3H-吲哚-3-亚基)甲基] -N - [(2S)-2- 羟基-3-吗啉-4-基丙基] -2,4-二甲基-1H-吡咯-3-甲酰胺盐,以及使用这些组合物治疗诸如癌症的疾病的方法。

    Quinuclidines-substituted-multi-cyclic-heteroaryls for treatment of disease
    8.
    发明申请
    Quinuclidines-substituted-multi-cyclic-heteroaryls for treatment of disease 审中-公开
    用于治疗疾病的喹喔啉取代的多环杂芳基

    公开(公告)号:US20050059698A1

    公开(公告)日:2005-03-17

    申请号:US10838596

    申请日:2004-05-04

    CPC分类号: C07D453/02

    摘要: The invention provides the malate salt of compounds of Formula I: A-NH-C(O)-B.X  Formula Iwherein X is malate salt, including D- or L-; wherein A is wherein B is or pharmaceutical composition, racemic mixture, or pure enantiomer thereof. The compounds of Formula I are useful to treat diseases or conditions in which α7 is known to be involved.

    摘要翻译: 本发明提供式I化合物的苹果酸盐:A-NH-C(O)-B.X式Ⅰ其中X是苹果酸盐,包括D-或L-; 其中A是其中B是或药物组合物,外消旋混合物或其纯对映异构体。 式I的化合物可用于治疗已知其中涉及α7的疾病或病症。

    Salts and polymorphs of a pyrrole-substituted indolinone compound
    10.
    发明申请
    Salts and polymorphs of a pyrrole-substituted indolinone compound 失效
    吡咯取代的吲哚啉酮化合物的盐和多晶型物

    公开(公告)号:US20050118255A1

    公开(公告)日:2005-06-02

    申请号:US10956420

    申请日:2004-09-30

    CPC分类号: C07D403/06

    摘要: The invention relates to non-hygroscopic salts of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, such as maleate salts, and to crystalline polymorphs of these salts. The invention further relates to pharmaceutical compositions of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide salts, and methods of treating disorders such as cancer using such compositions.

    摘要翻译: 本发明涉及5 - [(Z) - (5-氟-2-氧代-1,2-二氢-3H-吲哚-3-亚基)甲基] -N - [(2S)-2 - 羟基-3-吗啉-4-基丙基] -2,4-二甲基-1H-吡咯-3-甲酰胺,例如马来酸盐,以及这些盐的结晶多晶型物。 本发明还涉及5 - [(Z) - (5-氟-2-氧代-1,2-二氢-3H-吲哚-3-亚基)甲基] -N - [(2S)-2- 羟基-3-吗啉-4-基丙基] -2,4-二甲基-1H-吡咯-3-甲酰胺盐,以及使用这些组合物治疗诸如癌症的疾病的方法。