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公开(公告)号：US08691527B2
公开(公告)日：2014-04-08
申请号：US11841644
申请日：2007-08-20
CPC分类号： C12N15/635 , C07K14/70567 , C07K14/721 , C12N7/00 , C12N15/86 , C12N2710/10043 , C12P21/02
摘要： This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
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公开(公告)号：US09322026B2
公开(公告)日：2016-04-26
申请号：US13618693
申请日：2012-09-14
IPC分类号： C12P21/06 , C12N15/63 , C07K14/705 , C07K14/72 , C12P21/02 , C12P21/04 , C12N5/07 , C12N5/071 , C12N5/00 , C12N15/00 , C07H21/02 , C07H21/04
CPC分类号： C12N15/635 , C07K14/70567 , C07K14/721 , C12N7/00 , C12N15/86 , C12N2710/10043 , C12P21/02
摘要： This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
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3.发明授权Substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system 有权取代突变体受体及其在基于核受体的诱导型基因表达系统中的应用公开(公告)号：US09029152B2
公开(公告)日：2015-05-12
申请号：US13615348
申请日：2012-09-13
IPC分类号： C12N15/63 , C07K14/705 , C07K14/72 , C12P21/02
CPC分类号： C12N15/635 , C07K14/70567 , C07K14/721 , C12N7/00 , C12N15/86 , C12N2710/10043 , C12P21/02
摘要： This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
摘要翻译： 本发明涉及生物技术或遗传工程领域。 具体地，本发明涉及基因表达领域。 更具体地，本发明涉及新的取代突变体受体及其在基于H核受体的诱导型基因表达系统中的用途以及调节宿主细胞中基因表达的方法，用于基因治疗，大规模生产 蛋白质和抗体，基于细胞的高通量筛选测定，功能基因组学和转基因生物体中性状的调节。
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4.发明申请NOVEL SUBSTITUTION MUTANT RECEPTORS AND THEIR USE IN A NUCLEAR RECEPTOR-BASED INDUCIBLE GENE EXPRESSION SYSTEM 有权新型替代突变体受体及其在基于受体基因的诱导基因表达系统中的应用公开(公告)号：US20080301825A1
公开(公告)日：2008-12-04
申请号：US11841644
申请日：2007-08-20
CPC分类号： C12N15/635 , C07K14/70567 , C07K14/721 , C12N7/00 , C12N15/86 , C12N2710/10043 , C12P21/02
摘要： This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
摘要翻译： 本发明涉及生物技术或遗传工程领域。 具体地，本发明涉及基因表达领域。 更具体地，本发明涉及新的取代突变体受体及其在基于H核受体的诱导型基因表达系统中的用途以及调节宿主细胞中基因表达的方法，用于基因治疗，大规模生产 蛋白质和抗体，基于细胞的高通量筛选测定，功能基因组学和转基因生物体中性状的调节。
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5.发明授权Substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system 有权取代突变体受体及其在基于核受体的诱导型基因表达系统中的应用公开(公告)号：US08715959B2
公开(公告)日：2014-05-06
申请号：US10468193
申请日：2002-02-20
CPC分类号： C12N15/635 , C07K14/70567 , C07K14/721 , C12N7/00 , C12N15/86 , C12N2710/10043 , C12P21/02
摘要： This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
摘要翻译： 本发明涉及生物技术或遗传工程领域。 具体地，本发明涉及基因表达领域。 更具体地，本发明涉及新的取代突变体受体及其在基于H核受体的诱导型基因表达系统中的用途以及调节宿主细胞中基因表达的方法，用于基因治疗，大规模生产 蛋白质和抗体，基于细胞的高通量筛选测定，功能基因组学和转基因生物体中性状的调节。
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公开(公告)号：US08669051B2
公开(公告)日：2014-03-11
申请号：US11841529
申请日：2007-08-20
IPC分类号： C12Q1/68 , G01N33/567 , C12P21/06 , C12N5/00 , C12N5/07 , C12N5/02 , C12N1/20 , C12N1/38 , C12N15/00 , C07H21/04
CPC分类号： C12N15/635 , C07K14/70567 , C07K14/721 , C12N7/00 , C12N15/86 , C12N2710/10043 , C12P21/02
摘要： This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
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7.发明申请MUTANT RECEPTORS AND THEIR USE IN A NUCLEAR RECEPTOR-BASED INDUCIBLE GENE EXPRESSION SYSTEM 有权突变体受体及其在基于受体基因的诱导基因表达系统中的应用公开(公告)号：US20080145935A1
公开(公告)日：2008-06-19
申请号：US11841464
申请日：2007-08-20
CPC分类号： C12N15/85 , A61K31/16 , A61K31/47 , C07D215/44 , C07H21/04 , C07K14/43536 , C12N15/62 , C12N15/63 , C12N15/635 , Y10S530/858
摘要： This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
摘要翻译： 本发明涉及生物技术或遗传工程领域。 具体地，本发明涉及基因表达领域。 更具体地，本发明涉及新的取代突变体受体及其在基于核受体的诱导型基因表达系统中的用途以及调节宿主细胞中基因表达的方法，用于诸如基因治疗，大规模生产蛋白质和 抗体，基于细胞的高通量筛选测定，功能基因组学和转基因生物体中性状的调节。
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公开(公告)号：US20130276156A1
公开(公告)日：2013-10-17
申请号：US13613597
申请日：2012-09-13
申请人： Tarlochan Singh DHADIALLA , Dean Ervin Cress , Glenn Richard Carlson , Robert Eugene Hormann , Subba Reddy Palli , Arthur John Kudla , Ronald Phillip Herzig, JR. , Mohan Philip
发明人： Tarlochan Singh DHADIALLA , Dean Ervin Cress , Glenn Richard Carlson , Robert Eugene Hormann , Subba Reddy Palli , Arthur John Kudla , Ronald Phillip Herzig, JR. , Mohan Philip
IPC分类号： C12N15/85
CPC分类号： C12N15/635 , A01K2217/05 , A61K48/00 , C07K14/721 , C07K2319/00 , C12N15/70 , C12N15/74 , C12N15/80 , C12N15/81 , C12N15/8217 , C12N15/8238 , C12N15/8241 , C12N15/85 , C12N15/861 , G01N33/6845
摘要： The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions within cells to simultaneously control the quantitative expression of multiple genes.
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公开(公告)号：US20120322148A1
公开(公告)日：2012-12-20
申请号：US13463527
申请日：2012-05-03
CPC分类号： C12N15/63 , C07K2319/71 , C07K2319/715 , C07K2319/80 , C12N15/1055 , C12N15/85 , C12N2510/00 , C12N2830/002 , C12N2830/15
摘要： This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic plants and animals.
摘要翻译： 本发明涉及生物技术或遗传工程领域。 具体地，本发明涉及基因表达领域。 更具体地，本发明涉及一种新的诱导型基因表达系统和调节宿主细胞中基因表达的方法，用于诸如基因治疗，蛋白质和抗体的大规模生产，基于细胞的高通量筛选测定，功能基因组学和调节 的转基因植物和动物的性状。
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公开(公告)号：US07776587B2
公开(公告)日：2010-08-17
申请号：US11841495
申请日：2007-08-20
CPC分类号： C12N15/63 , C07K2319/71 , C07K2319/715 , C07K2319/80 , C12N15/1055 , C12N15/85 , C12N2510/00 , C12N2830/002 , C12N2830/15
摘要： This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic plants and animals.
摘要翻译： 本发明涉及生物技术或遗传工程领域。 具体地，本发明涉及基因表达领域。 更具体地，本发明涉及一种新的诱导型基因表达系统和调节宿主细胞中基因表达的方法，用于诸如基因治疗，蛋白质和抗体的大规模生产，基于细胞的高通量筛选测定，功能基因组学和调节 的转基因植物和动物的性状。
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