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公开(公告)号:US20080227970A1
公开(公告)日:2008-09-18
申请号:US11929084
申请日:2007-10-30
申请人: Suhaib Siddiqi , Hernan Orgueira , Edyta Kvzymanska-Olejnik , Subramanian Marappan , Philip R. Buzby , Atanu Roy
发明人: Suhaib Siddiqi , Hernan Orgueira , Edyta Kvzymanska-Olejnik , Subramanian Marappan , Philip R. Buzby , Atanu Roy
IPC分类号: C07H19/04
CPC分类号: C07H21/04
摘要: The invention provides a family of tethered nucleotide analogs useful in sequencing nucleic acids containing a homopolymer region comprising, for example, two or more base repeats, and to sequencing methods using such tethered nucleotide analogs.
摘要翻译: 本发明提供了可用于测序含有包含例如两个或更多个碱基重复序列的均聚物区域的核酸的系链核苷酸类似物家族,以及使用这种系链核苷酸类似物的测序方法。
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公开(公告)号:US07994304B2
公开(公告)日:2011-08-09
申请号:US11929084
申请日:2007-10-30
申请人: Suhaib Siddiqi , Hernan Orgueira , Edyta Olejnik , Subramanian Marappan , Philip R. Buzby , Atanu Roy
发明人: Suhaib Siddiqi , Hernan Orgueira , Edyta Olejnik , Subramanian Marappan , Philip R. Buzby , Atanu Roy
IPC分类号: C07H21/04
CPC分类号: C07H21/04
摘要: The invention provides a family of tethered nucleotide analogs useful in sequencing nucleic acids containing a homopolymer region comprising, for example, two or more base repeats, and to sequencing methods using such tethered nucleotide analogs.
摘要翻译: 本发明提供了可用于测序含有例如两个或多个碱基重复序列的均聚物区域的核酸的拴系核苷酸类似物家族,以及使用这种拴系的核苷酸类似物的测序方法。
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公开(公告)号:US20080103053A1
公开(公告)日:2008-05-01
申请号:US11803339
申请日:2007-05-14
申请人: Suhaib Siddiqi , Hernan Orgueira , Edyta Krzymanska-Olejnik , Subramanian Marappan , Philip R. Buzby , Atanu Roy
发明人: Suhaib Siddiqi , Hernan Orgueira , Edyta Krzymanska-Olejnik , Subramanian Marappan , Philip R. Buzby , Atanu Roy
CPC分类号: C07H21/04
摘要: The invention provides a family of tethered nucleotide analogs useful in sequencing nucleic acids containing a homopolymer region comprising, for example, two or more base repeats, and to sequencing methods using such tethered nucleotide analogs.
摘要翻译: 本发明提供了可用于测序含有包含例如两个或更多个碱基重复序列的均聚物区域的核酸的系链核苷酸类似物家族,以及使用这种系链核苷酸类似物的测序方法。
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公开(公告)号:US20120040340A1
公开(公告)日:2012-02-16
申请号:US13283220
申请日:2011-10-27
申请人: J. William Efcavitch , Suhaib Siddiqi , Philip R. Buzby , Judith Mitchell , Edyta Krzymanska-Olejnik , Subramanian Marappan , Xiaopeng Bai , Atanu Roy , Mirna Jarosz , Jayson Bowers
发明人: J. William Efcavitch , Suhaib Siddiqi , Philip R. Buzby , Judith Mitchell , Edyta Krzymanska-Olejnik , Subramanian Marappan , Xiaopeng Bai , Atanu Roy , Mirna Jarosz , Jayson Bowers
CPC分类号: C07H21/04
摘要: The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
摘要翻译: 本发明提供核苷酸类似物及其使用方法,例如用于测序核酸。
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公开(公告)号:US08071755B2
公开(公告)日:2011-12-06
申请号:US12098196
申请日:2008-04-04
申请人: J. William Efcavitch , Suhaib Siddiqi , Philip R. Buzby , Judith Mitchell , Edyta Krzymanska-Olejnik , Subramanian Marappan , Xiaopeng Bai , Atanu Roy , Mirna Jarosz , Jayson Bowers
发明人: J. William Efcavitch , Suhaib Siddiqi , Philip R. Buzby , Judith Mitchell , Edyta Krzymanska-Olejnik , Subramanian Marappan , Xiaopeng Bai , Atanu Roy , Mirna Jarosz , Jayson Bowers
IPC分类号: C07H21/00
CPC分类号: C07H21/04
摘要: The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
摘要翻译: 本发明提供核苷酸类似物及其使用方法,例如用于测序核酸。
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公开(公告)号:US20090061437A1
公开(公告)日:2009-03-05
申请号:US12098196
申请日:2008-04-04
申请人: J. William Efcavitch , Suhaib Siddiqi , Philip R. Buzby , Judith Mitchell , Edyta Krzymanska-Olejnik , Subramanian Marappan , Xiaopeng Bai , Atanu Roy , Mirna Jarosz , Jayson Bowers
发明人: J. William Efcavitch , Suhaib Siddiqi , Philip R. Buzby , Judith Mitchell , Edyta Krzymanska-Olejnik , Subramanian Marappan , Xiaopeng Bai , Atanu Roy , Mirna Jarosz , Jayson Bowers
CPC分类号: C07H21/04
摘要: The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
摘要翻译: 本发明提供核苷酸类似物及其使用方法,例如用于测序核酸。
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公开(公告)号:US08114973B2
公开(公告)日:2012-02-14
申请号:US12244698
申请日:2008-10-02
申请人: Suhaib Siddiqi , Subramanian Marappan , Judith Mitchell , Edyta Krzymanska-Olejnik , Atanu Roy , Xiaopeng Bai
发明人: Suhaib Siddiqi , Subramanian Marappan , Judith Mitchell , Edyta Krzymanska-Olejnik , Atanu Roy , Xiaopeng Bai
CPC分类号: C07H21/04
摘要: The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
摘要翻译: 本发明提供核苷酸类似物及其使用方法,例如用于测序核酸。
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公开(公告)号:US20090186351A1
公开(公告)日:2009-07-23
申请号:US12244698
申请日:2008-10-02
申请人: Suhaib Siddiqi , Subramanian Marappan , Judith Mitchell , Edyta Krzymanska-Olejnik , Atanu Roy , Xiaopeng Bai
发明人: Suhaib Siddiqi , Subramanian Marappan , Judith Mitchell , Edyta Krzymanska-Olejnik , Atanu Roy , Xiaopeng Bai
CPC分类号: C07H21/04
摘要: The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.
摘要翻译: 本发明提供核苷酸类似物及其使用方法,例如用于测序核酸。
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9.Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions 审中-公开
标题翻译: 捕获化合物,其收集物和分析蛋白质组合物和复合物组合物的方法公开(公告)号:US20050042771A1
公开(公告)日:2005-02-24
申请号:US10760085
申请日:2004-01-16
申请人: Hubert Koster , Daniel Little , Suhaib Siddiqi , Matthew Grealish , Subramanian Marappan , Chester Hassman , Ping Yip
发明人: Hubert Koster , Daniel Little , Suhaib Siddiqi , Matthew Grealish , Subramanian Marappan , Chester Hassman , Ping Yip
IPC分类号: C07C69/76 , C07C69/96 , C07D207/40 , C07D207/404 , C07D207/46 , C07D209/48 , C07D211/60 , C07D211/78 , C07D213/79 , C07D215/48 , C07D239/54 , C07D239/545 , C07D241/44 , C07D261/12 , C07D271/06 , C07D271/07 , C07D303/14 , C07D303/16 , C07D317/36 , C07D401/12 , C07D405/10 , C07D405/12 , C07D495/04 , C07D498/18 , C07D519/00 , G01N33/68 , G01N33/543
CPC分类号: C07D495/04 , C07C69/76 , C07C69/96 , C07C2603/74 , C07D207/404 , C07D207/46 , C07D209/48 , C07D211/60 , C07D211/78 , C07D213/79 , C07D215/48 , C07D239/54 , C07D239/545 , C07D241/44 , C07D261/12 , C07D271/07 , C07D303/14 , C07D303/16 , C07D317/36 , C07D401/12 , C07D405/10 , C07D405/12 , C07D417/12 , C07D417/14 , C07D519/00 , G01N33/6803 , G01N33/6842 , G01N33/6845 , G01N33/6848
摘要: Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.
摘要翻译: 提供捕获化合物及其收集物和使用该化合物分析生物分子的方法。 特别地,提供收集,化合物和方法用于分析复合蛋白质混合物,例如蛋白质组。 这些化合物是提供复杂蛋白质混合物分离和分离的多功能试剂。 还提供了用于执行方法的自动化系统。
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公开(公告)号:US09163053B2
公开(公告)日:2015-10-20
申请号:US12631074
申请日:2009-12-04
申请人: Suhaib Siddiqi , J. William Efcavitch , Judith Mitchell , Subramanian Marappan , Jayson Bowers , Mirna Jaroza
发明人: Suhaib Siddiqi , J. William Efcavitch , Judith Mitchell , Subramanian Marappan , Jayson Bowers , Mirna Jaroza
IPC分类号: C07H19/00 , C07H19/04 , C07H21/02 , C12Q1/68 , C12P19/34 , C07H19/06 , C07H19/16 , A61K49/00
CPC分类号: C12Q1/6876 , A61K49/0041 , A61K49/0052 , C07H19/06 , C07H19/16 , C12Q1/6869 , C12Q2563/107
摘要: The invention generally relates to nucleotide analogs and methods of their use in sequencing-by-synthesis reactions. In certain embodiments, the invention provides a nucleotide analog including a detectable label attached to a nitrogenous base portion of a nucleotide analog by a cleavable linker, in which contact of the analog with at least one activating agent results in cleavage of the label and elimination of the linker, thereby producing a natural nucleotide, a 9-deaza-G, 9-deaza-A, or ψ-uridine.
摘要翻译: 本发明一般涉及核苷酸类似物及其在合成反应测序中的用途。 在某些实施方案中,本发明提供核苷酸类似物,其包括通过可切割接头连接到核苷酸类似物的含氮碱基部分的可检测标记,其中所述类似物与至少一种活化剂的接触导致标记的切割和消除 接头,从而产生天然核苷酸,9-脱氮-G,9-脱氮-A或ψ-尿苷。
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