公开(公告)号：US06413983B1

公开(公告)日：2002-07-02

申请号：US09724029

申请日：2000-11-28

申请人： Sung-Eun Yoo ,  Sun Kyung Lee ,  Kyu Yang Yi ,  Nak Jeong Kim ,  Jee Hee Suh ,  Hwa Sup Shin ,  Byung Ho Lee ,  Ho Won Seo ,  Hong Lim ,  Sun-Ok Kim ,  Dongha Lee ,  Insun Cho ,  Miae Namgung ,  Dongsoo Jang

发明人： Sung-Eun Yoo ,  Sun Kyung Lee ,  Kyu Yang Yi ,  Nak Jeong Kim ,  Jee Hee Suh ,  Hwa Sup Shin ,  Byung Ho Lee ,  Ho Won Seo ,  Hong Lim ,  Sun-Ok Kim ,  Dongha Lee ,  Insun Cho ,  Miae Namgung ,  Dongsoo Jang

IPC分类号： A01N4342

CPC分类号： C07D498/14 ,  C07D405/04

摘要： The present invention relates to novel benzopyranyl heterocycle derivatives of the formula 1, process for preparation thereof and pharmaceutical use of the benzopyranyl heterocycle derivatives. The benzopyranyl heterocycle derivatives of the present invention can be used for protecting heart, brain, retina and neuronal cell from “ischemia-reperfusion” injury, treatment for diseases related to it and suppressing lipid peroxidation. Wherein R1, R2, R3, R4, n and * are each defined in specification.

摘要翻译： 本发明涉及式1的新型苯并吡喃基杂环衍生物，其制备方法和苯并吡喃基杂环衍生物的药物用途。 本发明的苯并吡喃基杂环衍生物可用于保护心脏，脑，视网膜和神经元细胞免受“缺血再灌注”损伤，治疗与之相关的疾病和抑制脂质过氧化作用。其中R1，R2，R3，R4，n 和*各自在规范中定义。

公开(公告)号：US06323238B1

公开(公告)日：2001-11-27

申请号：US09693082

申请日：2000-10-20

申请人： Sung-Eun Yoo ,  Kyu Yang Yi ,  Sun Kyung Lee ,  Nak-Jeong Kim ,  Jee Hee Suh ,  Young Sook Park ,  Sun Kyung Hwang ,  Hwa Sup Shin ,  Byung Ho Lee ,  Ho Won Seo ,  Hong Lim ,  Sun-Ok Kim ,  In Sun Cho ,  Miae Namgoong ,  Dongsoo Jang

发明人： Sung-Eun Yoo ,  Kyu Yang Yi ,  Sun Kyung Lee ,  Nak-Jeong Kim ,  Jee Hee Suh ,  Young Sook Park ,  Sun Kyung Hwang ,  Hwa Sup Shin ,  Byung Ho Lee ,  Ho Won Seo ,  Hong Lim ,  Sun-Ok Kim ,  In Sun Cho ,  Miae Namgoong ,  Dongsoo Jang

IPC分类号： C07D31174

CPC分类号： C07D407/04 ,  A61K31/155 ,  A61K31/352 ,  C07D311/68

摘要： The present invention relates to novel benzopyranyl guanidine derivatives of the formula 1, process for preparation therof and pharmaceutical use of the benzopyranyl guanidine derivatives. The benzopyranyl guanidine derivatives of the present invention can be used for protecting heart, neuronal cell or brain damage, preserving organs, and also the benzopyranyl guanidine derivatives are pharmacologically useful for inhibiting NO generation, and for suppressing lipid peroxidation, angiogenesis or restenosis. Wherein R1, R2, R3, R4, R5, R6, n and * are each defined in specification.

摘要翻译： 本发明涉及式1的新型苯并吡喃基胍衍生物，其制备方法和苯并吡喃基胍衍生物的药物用途。 本发明的苯并吡喃基胍衍生物可用于保护心脏，神经元细胞或脑损伤，保存器官，苯并吡喃基胍衍生物在药理学上可用于抑制NO产生，抑制脂质过氧化，血管生成或再狭窄。其中R1 ，R2，R3，R4，R5，R6，n和*各自在说明书中定义。

公开(公告)号：US07279497B2

公开(公告)日：2007-10-09

申请号：US10523015

申请日：2003-07-30

申请人： Kyu Yang Yi ,  Sun Kyung Lee ,  Sung-Eun Yoo ,  Jee Hee Suh ,  Nak Jeong Kim ,  Sun Kyung Hwang ,  Byung-Ho Lee ,  Ho Won Seo ,  Chong Ock Lee ,  Sang-Un Choi

发明人： Kyu Yang Yi ,  Sun Kyung Lee ,  Sung-Eun Yoo ,  Jee Hee Suh ,  Nak Jeong Kim ,  Sun Kyung Hwang ,  Byung-Ho Lee ,  Ho Won Seo ,  Chong Ock Lee ,  Sang-Un Choi

IPC分类号： A61K31/4164 ,  C07D233/54

CPC分类号： C07D405/12

摘要： The present invention relates to benzopyran derivatives substituted with secondary amines including imidazole, their preparation, and pharmaceutical compositions containing them. The present invention is pharmacologically useful for the treatment of cancer, rheumatoid arthritis, and diabetic retinopathies through anti-angiogenic properties, and also pharmacologically useful in the protection of heart and neuronal cells against ischemia-reperfusion injury or preserving organs.

摘要翻译： 本发明涉及被仲胺包括咪唑取代的苯并吡喃衍生物，其制备方法和含有它们的药物组合物。 本发明在药理学上可用于通过抗血管生成特性治疗癌症，类风湿性关节炎和糖尿病性视网膜病变，并且还可用于保护心脏和神经细胞免受缺血再灌注损伤或保存器官的药理作用。

公开(公告)号：US07351843B2

公开(公告)日：2008-04-01

申请号：US10581799

申请日：2004-12-24

申请人： Kyu Yang Yi ,  Sun Kyung Lee ,  Nak Jeong Kim ,  Jee Hee Suh ,  Soon Hee Hwang ,  Byung Ho Lee ,  Ho Won Seo ,  Sun Kyung Hwang ,  Sung Eun Yoo ,  Kyung Hee Lee

发明人： Kyu Yang Yi ,  Sun Kyung Lee ,  Nak Jeong Kim ,  Jee Hee Suh ,  Soon Hee Hwang ,  Byung Ho Lee ,  Ho Won Seo ,  Sun Kyung Hwang ,  Sung Eun Yoo ,  Kyung Hee Lee

IPC分类号： C07D307/02 ,  A61K31/34 ,  A01N43/08

CPC分类号： C07D307/68

摘要： The present invention relates to furancarbonylguanidine derivatives, a preparation method thereof and a pharmaceutical composition comprising the same.Furancarbonylguanidine derivatives of the present invention inhibit NHE-1 (sodium-hydrogen exchanger isoform 1), which helps recovery of heart function damaged from ischemia/reperfusion and decreases myocardial infarction rate, indicating that they have protective effect on myocardial cells. Thus, furancarbonylguanidine derivatives of the present invention can be effectively used for the prevention and the treatment of ischemic heart diseases such as myocardial infarction, arrhythmia, angina pectoris, etc, and also a promising candidate for a heart protecting agent applied to reperfusion therapy including thrombolytics or cardiac surgery including coronary artery bypass graft, percutaneous transluminal coronary angioplasty, etc.

摘要翻译： 本发明涉及呋喃羰基胍衍生物，其制备方法和包含其的药物组合物。 本发明的呋喃羰基胍衍生物抑制NHE-1（钠氢交换异构体1），其有助于恢复从缺血/再灌注损伤的心脏功能，并降低心肌梗死率，表明它们对心肌细胞具有保护作用。 因此，本发明的呋喃羰基胍衍生物可以有效地用于预防和治疗心肌梗死，心律失常，心绞痛等缺血性心脏病，也是应用于再灌注治疗的心脏保护剂的有希望的候选物，包括溶栓剂 或心脏手术，包括冠状动脉旁路移植术，经皮腔内冠状动脉血管成形术等