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公开(公告)号:US20050070523A1
公开(公告)日:2005-03-31
申请号:US10931400
申请日:2004-09-01
申请人: Susan Hagen , Vara Prasad Josyula
发明人: Susan Hagen , Vara Prasad Josyula
IPC分类号: A61K31/519 , A61K31/53 , A61K31/55 , A61P31/04 , C07D401/14 , C07D413/14 , C07D471/04 , C07D487/02 , C07D498/06
CPC分类号: C07D413/14 , C07D401/14 , C07D471/04
摘要: Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications, including using the invention compounds to treat bacterial infections.
摘要翻译: 公开了式I化合物及其制备方法。 还公开了制备式I的生物活性化合物的方法以及包含式I化合物的药学上可接受的组合物的方法。本文公开的式I化合物可用于多种应用,包括使用本发明化合物治疗细菌感染。
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公开(公告)号:US07304050B2
公开(公告)日:2007-12-04
申请号:US10931400
申请日:2004-09-01
IPC分类号: A61P31/04 , A61K31/55 , C07D223/16
CPC分类号: C07D413/14 , C07D401/14 , C07D471/04
摘要: Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications, including using the invention compounds to treat bacterial infections.
摘要翻译: 公开了式I化合物及其制备方法。 还公开了制备式I的生物活性化合物的方法以及包含式I化合物的药学上可接受的组合物的方法。本文公开的式I化合物可用于多种应用,包括使用本发明化合物治疗细菌感染。
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公开(公告)号:US20050288273A1
公开(公告)日:2005-12-29
申请号:US10774241
申请日:2004-02-06
申请人: Frederick Boyer , Allison Choy , Louis Chupak , Susan Hagen , Joysula Venkata Prasad , Takushi Kaneko , Ji-Young Kim
发明人: Frederick Boyer , Allison Choy , Louis Chupak , Susan Hagen , Joysula Venkata Prasad , Takushi Kaneko , Ji-Young Kim
IPC分类号: A61K31/55 , A61P31/04 , C07D263/38 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D498/04
CPC分类号: C07D263/38 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04
摘要: Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.
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公开(公告)号:US20050075390A1
公开(公告)日:2005-04-07
申请号:US10938442
申请日:2004-09-09
申请人: Frederick Boyer , John Domagala , Edmund Ellsworth , Christopher Gajda , Susan Hagen , Michael Lovdahl , Elizabeth Lunney , Larry Markoski , Josyula Venkata Prasad , Bradley Tait
发明人: Frederick Boyer , John Domagala , Edmund Ellsworth , Christopher Gajda , Susan Hagen , Michael Lovdahl , Elizabeth Lunney , Larry Markoski , Josyula Venkata Prasad , Bradley Tait
IPC分类号: C07D233/64 , A61K31/351 , A61K31/381 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/443 , A61K31/4433 , A61P31/14 , A61P31/18 , C07D207/333 , C07D209/12 , C07D209/30 , C07D213/30 , C07D213/71 , C07D231/12 , C07D235/06 , C07D235/26 , C07D239/26 , C07D239/42 , C07D241/44 , C07D277/20 , C07D277/24 , C07D277/46 , C07D277/82 , C07D307/12 , C07D307/42 , C07D309/32 , C07D333/16 , C07D333/32 , C07D333/62 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/06 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/12 , C07D417/14 , C07D309/30 , A61K31/366
CPC分类号: C07D405/06 , C07D309/32 , C07D405/12 , C07D405/14 , C07D407/06 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/12 , C07D417/14
摘要: The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.
摘要翻译: 本发明涉及具有改善的药理学性质的具有栓系杂环的新型二氢吡喃酮,其有效抑制HIV天冬氨酰蛋白酶阻断HIV感染性。 二氢吡喃可用于开发用于治疗病毒感染和疾病(包括AIDS)的治疗。 本发明还涉及合成二氢吡喃的方法和可用于制备最终化合物的中间体。
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