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31 条记录 (耗时 0.031 秒)

    CYCLIC DEPSIPEPTIDE COMPOUND AND USE THEREOF
    1.
    发明申请
    CYCLIC DEPSIPEPTIDE COMPOUND AND USE THEREOF 审中-公开
    环糊精化合物及其用途

    公开(公告)号：US20110207655A1

    公开(公告)日：2011-08-25

    申请号：US13126363

    申请日：2009-10-23

    申请人： Susumu Tsujimoto ,  Masatoshi Taniguchi ,  Yoshitaka Hirayama ,  Jun Takasaki ,  Tomihisa Kawasaki ,  Kazutoshi Sakamoto ,  Shinya Nishiwaki ,  Yukihiro Kitanaga

    发明人： Susumu Tsujimoto ,  Masatoshi Taniguchi ,  Yoshitaka Hirayama ,  Jun Takasaki ,  Tomihisa Kawasaki ,  Kazutoshi Sakamoto ,  Shinya Nishiwaki ,  Yukihiro Kitanaga

    IPC分类号： A61K38/15 ,  C07K11/02 ,  A61P11/00 ,  A61P11/06

    CPC分类号： A61K38/12 ,  A61K38/15 ,  C07K11/00

    摘要： [Problem]A compound useful for the prevention and/or treatment of chronic obstructive pulmonary disease (COPD) or asthma, and a pharmaceutical composition containing the compound as an active ingredient are provided.[Means for Solution]The present inventors have made extensive studies on the pharmacological actions of naturally fermented materials, and as a result, they have found that a cyclic depsipeptide compound derived from a soil bacterium belonging to the genus Chromobacterium which is collected in Okutama-machi, Tokyo has both an inhibitory action on airway contraction and an inhibitory action on airway inflammation, and thus, is useful as an agent for preventing or treating COPD or asthma, thereby completing the present invention. That is, the present invention relates to a pharmaceutical composition for preventing and/or treating chronic obstructive pulmonary disease (COPD) or asthma, which contains a cyclic depsipeptide compound or a salt thereof as an active ingredient and is intended to be administered by intratracheal administration, nasal drop administration, or inhalation administration.

    摘要翻译： [问题]提供了用于预防和/或治疗慢性阻塞性肺疾病（COPD）或哮喘的化合物和含有该化合物作为活性成分的药物组合物。 [解决方案]本发明人对天然发酵材料的药理作用进行了广泛的研究，结果发现，源自属于Chromobacterium属的土壤细菌的环状缩肽化合物是在Okutama- 东京都有对气道收缩的抑制作用和对气道炎症的抑制作用，因此可用作预防或治疗COPD或哮喘的药剂，从而完成了本发明。 也就是说，本发明涉及用于预防和/或治疗慢性阻塞性肺疾病（COPD）或哮喘的药物组合物，其包含环状缩肽化合物或其盐作为活性成分，并且旨在通过气管内给药 ，滴鼻给药或吸入给药。

    Flame-retardant epoxy resin composition, molded article thereof, and electronic part
    5.
    发明授权
    Flame-retardant epoxy resin composition, molded article thereof, and electronic part 失效
    阻燃性环氧树脂组合物，其成型体和电子部件

    公开(公告)号：US06797750B2

    公开(公告)日：2004-09-28

    申请号：US10221813

    申请日：2002-11-07

    申请人： Masatoshi Taniguchi ,  Yuji Tada ,  Yoichi Nishioka

    发明人： Masatoshi Taniguchi ,  Yuji Tada ,  Yoichi Nishioka

    IPC分类号： C08K549

    CPC分类号： H01L23/49894 ,  C08G59/4071 ,  C08G79/025 ,  C08K5/5399 ,  C08L63/00 ,  C08L85/02 ,  H01L23/145 ,  H01L23/293 ,  H01L2924/0002 ,  H05K1/0373 ,  C08L85/00 ,  C08L71/00 ,  H01L2924/00

    摘要： The present invention has an object to provide a flame-retardant epoxy resin composition excellent in heat resistance and moisture resistance. A flame-retardant epoxy resin composition relating to the present invention contains an epoxy resin (A), a phosphazene compound (B), an epoxy hardener (C) and an inorganic filler (D), wherein the phosphazene compound (B) and the epoxy hardener (C) are included in the range of 0.01 to 70% by weight and in the range of 0 to 70% by weight, respectively, relative to a total quantity of the epoxy resin (A), the phosphazene compound (B) and the epoxy hardener (C), and the inorganic filler (D) is included in the range of 0 to 95% by weight relative to a total quantity of the epoxy resin (A), the phosphazene compound (B), the epoxy hardener (C) and the inorganic filler (D), wherein the phosphazene compound (B) is at least one selected from the group consisting of (1) a cyclic and/or a chain phosphazene compound with a specific structure, (2) a polymer of the cyclic and/or the chain phosphazene compound; and (3) a reaction product of the cyclic and/or the chain phosphazene compound with one type of a compound selected from the group consisting of an epoxy compound, a phenol compound, an amine compound and an acid anhydride.

    摘要翻译： 本发明的目的是提供耐热性和耐湿性优异的阻燃性环氧树脂组合物。 本发明的阻燃性环氧树脂组合物含有环氧树脂（A），磷腈化合物（B），环氧硬化剂（C）和无机填料（D），其中磷腈化合物（B）和 相对于环氧树脂（A），磷腈化合物（B）的总量，环氧固化剂（C）的含量分别为0.01〜70重量％，0〜70重量％ 环氧固化剂（C）和无机填料（D）的含量相对于环氧树脂（A），磷腈化合物（B），环氧固化剂（B）的总量为0〜95重量％ （C）和无机填料（D），其中磷腈化合物（B）为选自（1）具有特定结构的环状和/或链状磷腈化合物中的至少一种，（2）聚合物 的环状和/或链状磷腈化合物; 和（3）环状和/或链状磷腈化合物与一种选自环氧化合物，酚化合物，胺化合物和酸酐的化合物的反应产物。

    Process for preparing thiazolino azetidinone and 2-exo-methylenepenam derivative
    6.
    发明授权
    Process for preparing thiazolino azetidinone and 2-exo-methylenepenam derivative 失效
    制备噻唑基氮杂环丁酮和2-外 - 亚甲基台am am嗪衍生物的方法

    公开(公告)号：US5288860A

    公开(公告)日：1994-02-22

    申请号：US3024

    申请日：1993-01-11

    申请人： Sigeru Torii ,  Hideo Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Takashi Shiroi ,  Yutaka Kameyama

    发明人： Sigeru Torii ,  Hideo Tanaka ,  Masatoshi Taniguchi ,  Michio Sasaoka ,  Takashi Shiroi ,  Yutaka Kameyama

    IPC分类号： C07D499/00 ,  C07D499/04 ,  C07D499/12 ,  C07D499/87 ,  C07D513/04

    CPC分类号： C07D513/04 ,  C07D499/00 ,  Y02P20/55

    摘要： The present invention provides a thiazolinoazetidinone derivative represented by the formula ##STR1## wherein R.sup.1 is phenyl having or not having substituent(s), methyl having or not having substituent(s) or ##STR2## group, R.sup.3 being phenyl having or not having substituent(s), and R.sup.2 is a hydrogen atom or carboxylic acid protective group, and a process for preparing the same.The present invention further provides a process for preparing a 2-exo-methylenepenam derivative characterized by hydrolyzing the thiazoline ring of a thiazolinoazetidinone derivative of the above formula (1) to effect recyclization and obtain a 2-exo-methylenepenam derivative represented by the formula ##STR3## wherein R.sup.1 and R.sup.2 are as defined above.

    摘要翻译： 本发明提供由式（1）表示的噻唑并氮杂环丁酮衍生物，其中R 1是具有或不具有取代基的苯基，具有或不具有取代基的甲基或基团，R3是具有或不具有取代基的苯基， 不具有取代基，R2为氢原子或羧酸保护基，及其制备方法。 本发明进一步提供了制备2-异亚甲基台内叶酸衍生物的方法，其特征在于水解上述式（1）的噻唑并氮杂环丁酮衍生物的噻唑啉环以进行再循环，得到式（1）所示的2-外 - 亚甲基山梨醇衍生物， 图像（3）其中R1和R2如上所定义。