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公开(公告)号:US20140378509A1
公开(公告)日:2014-12-25
申请号:US14473338
申请日:2014-08-29
申请人: TAKEDA GMBH
发明人: Beate SCHMIDT , Christian SCHEUFLER , Jürgen VOLZ , Martin FETH , Rolf-Peter HUMMEL , Armin HATZELMANN , Christof ZITT , Andrea WOHLSEN , Degenhard MARX , Hans-Peter KLEY , Deborah OCKERT , Anke HEUSER , Johannes A.M. CHRISTIAANS , Geert Jan STERK , Wiro M.P.B. MENGE
IPC分类号: C07D401/14
CPC分类号: C07D401/14 , A61K31/4152
摘要: The compound 1-(2-{4-[3-(3,4-dimethoxyphenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}-2-oxoethyl)pyrrolidine-2,5-dione is a novel effective inhibitor of the type 4 phosphodiesterase useful in the treatment of psoriasis or atopic dermatitis.
摘要翻译: 化合物1-(2- {4- [3-(3,4-二甲氧基苯基)-4,4-二甲基-5-氧代-4,5-二氢-1H-吡唑-1-基]哌啶-1-基 } -2-氧代乙基)吡咯烷-2,5-二酮是用于治疗牛皮癣或特应性皮炎的4型磷酸二酯酶的新型有效抑制剂。