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公开(公告)号:US09090597B2
公开(公告)日:2015-07-28
申请号:US14473338
申请日:2014-08-29
申请人: TAKEDA GMBH
发明人: Beate Schmidt , Christian Scheufler , Jürgen Volz , Martin Feth , Rolf-Peter Hummel , Armin Hatzelmann , Christof Zitt , Andrea Wohlsen , Degenhard Marx , Hans-Peter Kley , Deborah Ockert , Anke Heuser , Johannes A. M. Christiaans , Geert Jan Sterk , Wiro M. P. B. Menge
IPC分类号: C07D401/14 , A61K31/4152
CPC分类号: C07D401/14 , A61K31/4152
摘要: The compound 1-(2-{4-[3-(3,4-dimethoxyphenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl]piperidin-1-yl}-2-oxoethyl)pyrrolidine-2,5-dione is a novel effective inhibitor of the type 4 phosphodiesterase useful in the treatment of psoriasis or atopic dermatitis.
摘要翻译: 化合物1-(2- {4- [3-(3,4-二甲氧基苯基)-4,4-二甲基-5-氧代-4,5-二氢-1H-吡唑-1-基]哌啶-1-基 } -2-氧代乙基)吡咯烷-2,5-二酮是用于治疗牛皮癣或特应性皮炎的4型磷酸二酯酶的新型有效抑制剂。
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公开(公告)号:US08829189B2
公开(公告)日:2014-09-09
申请号:US14051835
申请日:2013-10-11
申请人: Takeda GMBH
IPC分类号: C07D401/04 , A61K31/473 , C07C309/04 , C07C309/05 , C07C57/15 , C07D401/10 , C07D401/14 , C07C309/30
CPC分类号: C07C57/15 , C07C309/04 , C07C309/05 , C07C309/30 , C07D401/04 , C07D401/10 , C07D401/14
摘要: Disclosed herein are salts of 6-heteroaryl substituted hexahydrophenanthridine PDE4 inhibiting compounds, which can be used in the pharmaceutical industry for the production of pharmaceutical compositions.
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