公开(公告)号：US20210347786A1

公开(公告)日：2021-11-11

申请号：US17280634

申请日：2019-09-27

申请人： Takeda Pharmaceutical Company Limited

发明人： Shinobu SASAKI ,  Yasutomi ASANO ,  Hironobu MAEZAKI ,  Ayumu SATO

IPC分类号： C07D498/04 ,  A61P1/00

摘要： The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.

公开(公告)号：US20220098180A1

公开(公告)日：2022-03-31

申请号：US17426971

申请日：2020-01-29

申请人： Takeda Pharmaceutical Company Limited

发明人： Masahiro ITO ,  Takeshi YAMAMOTO ,  Keiko KAKEGAWA ,  Hideyuki SUGIYAMA ,  Tohru MIYAZAKI ,  Yasuyoshi ARIKAWA ,  Tomohiro OKAWA ,  Jinichi YONEMORI ,  Osamu KUBO ,  Akinori TOITA ,  Takuto KOJIMA ,  Fumiaki KIKUCHI ,  Minoru SASAKI ,  Misaki HOMMA ,  Yasuhiro IMAEDA ,  Hironobu MAEZAKI ,  Shiinobu SASAKI ,  Ayumu SATO ,  Hirotaka KAMITANI ,  Yasutomi ASANO ,  Hironori KOKUBO ,  Masato YOSHIKAWA

IPC分类号： C07D413/10 ,  C07D271/06 ,  C07D413/14 ,  C07D417/14

摘要： The present invention provides a heterocyclic compound having a HDAC inhibitory action, which is useful for the treatment of central nervous system diseases including neurodegenerative diseases, and the like, and a medicament comprising the compound.
The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the description, or a salt thereof.

公开(公告)号：US20210139491A1

公开(公告)日：2021-05-13

申请号：US16622632

申请日：2018-06-19

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Kazuaki TAKAMI ,  Masaki SETO ,  Shinobu SASAKI ,  Haruhi ANDO ,  Masaki OGINO ,  Tomoko OHASHI ,  Toshihiro IMAEDA ,  Ikuo FUJIMORI ,  Yasuhiro TSUKIMI ,  Masami YAMADA ,  Kenichiro SHIMOKAWA ,  Takeshi WAKABAYASHI ,  Masataka MURAKAMI ,  Makoto FUSHIMI ,  Tomohiro OKAWA ,  Jinichi YONEMORI ,  Tomohiro OHASHI ,  Hideo SUZUKI ,  Hironobu MAEZAKI ,  Ayumu SATO ,  Yasutomi ASANO ,  Steve SWANN

IPC分类号： C07D491/048 ,  A61K31/4355 ,  A61P1/10

摘要： The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the specification, or a salt thereof.

公开(公告)号：US20190135799A1

公开(公告)日：2019-05-09

申请号：US16049359

申请日：2018-07-30

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Masahiro ITO ,  Hideyuki SUGIYAMA ,  Osamu KUBO ,  Fumiaki KIKUCHI ,  Takeshi YASUI ,  Keiko KAKEGAWA ,  Zenichi IKEDA ,  Tohru MIYAZAKI ,  Yasuyoshi ARIKAWA ,  Tomohiro OKAWA ,  Jinichi YONEMORI ,  Akinori TOITA ,  Takuto KOJIMA ,  Yasutomi ASANO ,  Ayumu SATO ,  Hironobu MAEZAKI ,  Shinobu SASAKI ,  Hironori KOKUBO ,  Misaki HOMMA ,  Minoru SASAKI ,  Yasuhiro IMAEDA

IPC分类号： C07D413/14 ,  C07D471/04 ,  A61P25/28 ,  C07D413/04 ,  C07D417/14

CPC分类号： C07D413/14 ,  A61P25/28 ,  C07D413/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

摘要： The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of central nervous system diseases including neurodegenerative disease, and the like, and a medicament comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

公开(公告)号：US20170096422A1

公开(公告)日：2017-04-06

申请号：US15127970

申请日：2015-03-23

申请人： Takeda Pharmaceutical Company Limited

发明人： Tetsuya TSUKAMOTO ,  Yoshihisa NAKADA ,  Michiyo MOCHIZUKI ,  Takafumi TAKAI ,  Tomoya YUKAWA ,  Zenyu SHIOKAWA ,  Taisuke KATOH ,  Masaki SETOH ,  Ayumu SATO ,  Takafumi YUKAWA

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07B59/00 ,  C07D519/00

CPC分类号： C07D471/04 ,  C07B59/002 ,  C07B2200/05 ,  C07D487/04 ,  C07D519/00

摘要： Provided is a compound having a superior PKC inhibitory action, and useful as a prophylactic or therapeutic agent for immune diseases, inflammatory diseases and the like, or a salt thereof. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a superior PKC inhibitory action, and is useful as a prophylactic or therapeutic agent for immune diseases, inflammatory diseases and the like.

公开(公告)号：US20170253591A1

公开(公告)日：2017-09-07

申请号：US15510225

申请日：2015-09-10

申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人： Satoshi YAMAMOTO ,  Junya SHIRAI ,  Tsuneo ODA ,  Takashi IMADA ,  Mitsunori KONO ,  Ayumu SATO ,  Yoshihide TOMATA ,  Atsuko OCHIDA ,  Naoki ISHII ,  Yusuke SASAKI ,  Yoshiyuki FUKASE ,  Tomoya YUKAWA ,  Shoji FUKUMOTO

IPC分类号： C07D471/04 ,  C07D413/12 ,  C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D239/96 ,  C07D409/14 ,  C07D403/12 ,  C07D401/12 ,  C07D417/14 ,  C07D401/14 ,  C07D413/14

CPC分类号： C07D471/04 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/551 ,  A61P1/00 ,  A61P11/00 ,  C07D239/96 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： The problem of the present invention is to provide a compound having a superior RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like. The present invention relates to a compound represented by the formula (I): [wherein each symbol is as described in the DESCRIPTION] or a salt thereof, which has an RORγt inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like.