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公开(公告)号：US20200237651A1
公开(公告)日：2020-07-30
申请号：US16738482
申请日：2020-01-09
发明人： Avi AVRAMOFF , Helena SHIFRIN , Irena OLEINIK , Ron SCHLINGER , Tzviel SHESKIN , Vered ROSENBERGER
IPC分类号： A61K9/00 , A61K45/06 , A61K31/495 , A61K31/47
摘要： A topical formulation comprising Montelukast or a pharmaceutically acceptable salt thereof, a gelling agent and water for the treatment of atopic dermatitis.
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公开(公告)号：US20220016028A1
公开(公告)日：2022-01-20
申请号：US17489516
申请日：2021-09-29
发明人： Vered ROSENBERGER , Helena SHIFRIN , Irena OLEINIK , Tzviel SHESKIN , Ron SCHLINGER , Avi AVRAMOFF
摘要： The present disclosure provides for topical emulsion comprising about 0.5% to about 10% Montelukast or pharmaceutically acceptable salt thereof; and about 0.4% to about 4% carbomer; wherein particles comprising the Montelukast in the emulsion have D90 of less than about 50 wherein the Montelukast or pharmaceutically acceptable salt thereof is homogeneously dispersed in the emulsion, and wherein the emulsion has a pH of about 3.0 to about 6.5. The present disclosure also provides a topical gel comprising (a) about 0.5% to about 10% Montelukast or pharmaceutically acceptable salt thereof; (b) about 0.2% to about 8% cellulose polymer; and (c) about 80% to about 95% amphiphilic compound; wherein the gel comprises less than 4% water.
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公开(公告)号：US20230059107A1
公开(公告)日：2023-02-23
申请号：US17883687
申请日：2022-08-09
发明人： Helena SHIFRIN , Alexandra SHRAIFEL , Vered ROSENBERGER , Ron SCHLINGER , Tzviel SHESKIN , Avi AVRAMOFF
摘要： The present disclosure is directed to a topical composition, e.g., a physically and chemically stable topical composition of Fenoldopam comprising about 0.1% to about 5% by weight of Fenoldopam or a pharmaceutically acceptable salt thereof, at least one polyacrylamide-type gelling agent, at least one cellulose-type gelling agent, and at least one solvent, wherein the Fenoldopam is substantially solubilized in the composition, and wherein the composition is stable for at least twelve months at 25° C. and 60% relative humidity.
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公开(公告)号：US20210393613A1
公开(公告)日：2021-12-23
申请号：US17391813
申请日：2021-08-02
发明人： Vered ROSENBERGER , Helena SHIFRIN , Irena OLEINIK , Tzviel SHESKIN , Ron SCHLINGER , Avi AVRAMOFF
摘要： The present disclosure provides for topical emulsion comprising about 0.5% to about 10% Montelukast or pharmaceutically acceptable salt thereof; and about 0.4% to about 4% carbomer; wherein particles comprising the Montelukast in the emulsion have D90 of less than about 50 wherein the Montelukast or pharmaceutically acceptable salt thereof is homogeneously dispersed in the emulsion, and wherein the emulsion has a pH of about 3.0 to about 6.5. The present disclosure also provides a topical gel comprising (a) about 0.5% to about 10% Montelukast or pharmaceutically acceptable salt thereof; (b) about 0.2% to about 8% cellulose polymer; and (c) about 80% to about 95% amphiphilic compound; wherein the gel comprises less than 4% water.
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公开(公告)号：US20210236423A1
公开(公告)日：2021-08-05
申请号：US17165574
申请日：2021-02-02
发明人： Vered ROSENBERGER , Helena SHIFRIN , Irena OLEINIK , Tzviel SHESKIN , Ron SCHLINGER , Avi AVRAMOFF
摘要： The present disclosure provides for topical emulsion comprising about 0.5% to about 10% Montelukast or pharmaceutically acceptable salt thereof; and about 0.4% to about 4% carbomer; wherein particles comprising the Montelukast in the emulsion have D90 of less than about 50 μm, wherein the Montelukast or pharmaceutically acceptable salt thereof is homogeneously dispersed in the emulsion, and wherein the emulsion has a pH of about 3.0 to about 6.5. The present disclosure also provides a topical gel comprising (a) about 0.5% to about 10% Montelukast or pharmaceutically acceptable salt thereof; (b) about 0.2% to about 8% cellulose polymer; and (c) about 80% to about 95% amphiphilic compound; wherein the gel comprises less than 4% water.
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