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公开(公告)号:US20190328746A1
公开(公告)日:2019-10-31
申请号:US16329501
申请日:2017-08-30
申请人: TARO PHARMACEUTICAL INDUSTRIES LTD. , Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
发明人: Wahid KHAN , Helena SHIFRIN , Ron SCHLINGER , Avi AVRAMOFF , Avi DOMB
IPC分类号: A61K31/55 , A61K45/06 , A61K9/06 , A61K47/12 , A61K47/10 , A61K47/06 , A61K47/32 , A61P17/06 , A61K9/00 , A61K9/12 , A61K9/70
摘要: Embodiments of stable topical compositions for administering fenoldopam (compound (I) or a pharmaceutically acceptable salt or solvate thereof are disclosed for immediate or continued slow release administration, over prolonged periods of time with safe minimal systemic exposure of fenoldopam (reducing the risk for lowering blood pressure). The compositions include those compositions that increase the stability and skin absorption of the drug, particularly anhydrous semi-solid compositions and creams. This is accomplished by incorporating fenoldopam in soluble or dispersed form into semi-solid compositions like ointments or anhydrous gels that are not irritative. Embodiments of methods for using the topical compositions in the treatment of dermatological disorders including psoriasis, alopecia atopic dermatitis and vitiligo are disclosed.