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公开(公告)号：US20210102019A1
公开(公告)日：2021-04-08
申请号：US17126978
申请日：2020-12-18
发明人： Narumi YOKOTE , Masanori KURAMOTO
IPC分类号： C08F216/36 , C09D129/12 , C08F220/56 , C08F220/38 , C08F216/18 , C09D129/02 , C09D133/26 , A61L29/08 , A61L31/10
摘要： Disclosed is a hydrophilic copolymer including more than 50% by mol of a structural unit derived from a polymerizable monomer (A) from which a homopolymer having a lower critical solution temperature (LCST) is formed, a structural unit derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group (−SO3H), a sulfate group (−OSO3H), a sulfurous acid group (−OSO2H), and a group of salts thereof, and a structural unit derived from a polymerizable monomer (C) having a photoreactive group. Also disclosed is a medical device including the hydrophilic copolymer. The medical device exhibits high sliding property until it reaches a target lesion, and low sliding property after reaching the target lesion. Methods of making and using the hydrophilic copolymer and medical device are also described.
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公开(公告)号：US20220176022A1
公开(公告)日：2022-06-09
申请号：US17675063
申请日：2022-02-18
发明人： Masanori KURAMOTO
IPC分类号： A61L31/10 , C08F220/38 , A61L31/14 , A61L31/04 , A61L29/14 , A61L29/08 , A61L29/04 , A61L29/06
摘要： A medical device includes: a substrate layer; an adhesive layer formed on at least a part of the substrate layer and containing a hydrophilic copolymer (1) containing a structural unit derived from a polymerizable monomer (A) having a sulfobetaine structure, a structural unit derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group (—SO3H), a sulfuric acid group (—OSO3H), a sulfurous acid group (—OSO2H), and salt groups thereof, and a structural unit derived from a polymerizable monomer (C) having a photoreactive group; and a surface lubricious layer formed on at least a part of the adhesive layer and containing a polymer containing a structural unit derived from acrylamide and a hydrophilic copolymer (2).
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公开(公告)号：US20220168479A1
公开(公告)日：2022-06-02
申请号：US17675334
申请日：2022-02-18
发明人： Masanori KURAMOTO
IPC分类号： A61L31/10 , A61L31/14 , A61L29/14 , A61L29/08 , C08F220/38
摘要： The disclosure provides a medical device that exhibits an excellent lubricating property. The medical device includes: a substrate layer; and a surface lubricious layer formed on at least a part of the substrate layer and containing a hyaluronic acid or a salt thereof and a hydrophilic copolymer containing a structural unit derived from a polymerizable monomer (A) having a sulfobetaine structure, a structural unit derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group (—SO3H), a sulfuric acid group (—OSO3H), a sulfurous acid group (—OSO2H), and salt groups thereof, and a structural unit derived from a polymerizable monomer (C) having a photoreactive group.
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公开(公告)号：US20220168476A1
公开(公告)日：2022-06-02
申请号：US17675565
申请日：2022-02-18
发明人： Masanori KURAMOTO
IPC分类号： A61L29/08 , A61L31/10 , A61L29/14 , A61L31/14 , C08F220/38
摘要： medical device that exhibits an excellent lubricating property includes: a substrate layer; and a surface lubricious layer formed on at least a part of the substrate layer, with the surface lubricious layer containing a polymer containing a structural unit derived from acrylamide, and the surface lubricious layer containing a hydrophilic copolymer containing a structural unit derived from a polymerizable monomer (A) having a sulfobetaine structure, a structural unit derived from a polymerizable monomer (B) having at least one group selected from a group consisting of a sulfonic acid group (—SO3H), a sulfuric acid group (—OSO3H), a sulfurous acid group (—OSO2H), and salt groups thereof, and a structural unit derived from a polymerizable monomer (C) having a photoreactive group.
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公开(公告)号：US20220177618A1
公开(公告)日：2022-06-09
申请号：US17674891
申请日：2022-02-18
发明人： Masanori KURAMOTO , Narumi YOKOTE
IPC分类号： C08F16/30 , A61L31/14 , A61L31/04 , A61L31/06 , A61L29/04 , A61L29/06 , A61L29/14 , A61M25/00
摘要： A medical device includes: a substrate layer; an adhesive layer on at least a part of the substrate layer and containing a hydrophilic copolymer (1) containing a structural unit derived from a polymerizable monomer (A) having a sulfobetaine structure, a structural unit derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group (—SO3H), a sulfuric acid group (—OSO3H), a sulfurous acid group (—OSO2H), and salt groups thereof, and a structural unit derived from a polymerizable monomer (C) having a photoreactive group; and a surface lubricious layer formed on at least a part of the adhesive layer and containing a hyaluronic acid or a salt thereof and a hydrophilic copolymer (2).
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公开(公告)号：US20220168475A1
公开(公告)日：2022-06-02
申请号：US17675343
申请日：2022-02-18
发明人： Yuki UENO , Masanori KURAMOTO , Hiroki HOSONO , Hiromasa KOHAMA
摘要： A medical device that exhibits an excellent lubricating property includes: a substrate layer; and a surface lubricious layer formed on at least a part of the substrate layer, and containing a hydroxy group-containing compound selected from a group consisting of a non-volatile alcohol, a partially esterified product thereof, and a partially etherified product thereof, and soluble in water, and a hydrophilic copolymer containing a structural unit derived from a polymerizable monomer (A) having a sulfobetaine structure, a structural unit derived from a polymerizable monomer (B) having at least one group selected from a group consisting of a sulfonic acid group (—SO3H), a sulfuric acid group (—OSO3H), a sulfurous acid group (—OSO2H), and salt groups thereof, and a structural unit derived from a polymerizable monomer (C) having a photoreactive group.
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公开(公告)号：US20200376171A1
公开(公告)日：2020-12-03
申请号：US16996017
申请日：2020-08-18
发明人： Masanori KURAMOTO , Narumi YOKOTE
IPC分类号： A61L29/14 , A61L29/04 , C08F220/38 , C09J133/14
摘要： Disclosed is a medical device exhibiting superior lubricating property and durability (lubrication retaining property), the medical device comprising a substrate layer, an adhesive layer formed on at least a portion of the substrate layer, comprising a hydrophilic copolymer comprising a structural unit derived from a polymerizable monomer (A) having a sulfobetaine structure, a structural unit derived from a polymerizable monomer (B) having at least one group selected from the group consisting of a sulfonic acid group, sulfuric acid group, sulfurous acid group, and salts thereof, and a structural unit derived from a polymerizable monomer (C) having a photoreactive group, and a surface lubricious layer formed on at least a portion of the adhesive layer, comprising a hydrophilic polymer dissolvable in a solvent capable of dissolving or swelling the hydrophilic copolymer. Also disclosed are methods for producing medical devices exhibiting superior lubricating property and durability (lubrication retaining property).
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