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公开(公告)号:US20220251100A1
公开(公告)日:2022-08-11
申请号:US17729918
申请日:2022-04-26
发明人: John D. Imig , John R. Falck , Abdul Hye Khan , Adeniyi Adebesin
IPC分类号: C07D487/04 , A61P13/12 , C07D519/00
摘要: Described here are EET analogs conjugated to folate receptor ligands such as folic acid or folic acid analogs recognized by and selectively bound by folate receptors and other folate binding proteins and the use of such conjugated EET analogs for targeted delivery of therapeutic agents to folate-receptor bearing cell populations. More particularly, provided herein are EET analogs conjugated to folate receptor ligands and uses of such conjugated EET analogs as kidney targeted therapeutics.
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公开(公告)号:US11358968B2
公开(公告)日:2022-06-14
申请号:US16647603
申请日:2018-09-14
发明人: John D. Imig , John R. Falck , Abdul Hye Khan , Adeniyi Adebesin
IPC分类号: A61K31/4985 , C07D487/04 , A61P13/12 , C07D519/00
摘要: Described here are EET analogs conjugated to folate receptor ligands such as folic acid or folic acid analogs recognized by and selectively bound by folate receptors and other folate binding proteins and the use of such conjugated EET analogs for targeted delivery of therapeutic agents to folate-receptor bearing cell populations. More particularly, provided herein are EET analogs conjugated to folate receptor ligands and uses of such conjugated EET analogs as kidney targeted therapeutics.
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