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    COMPOSITIONS, METHODS AND USES FOR THERMALLY STABLE HUMAN PAPILLOMAVIRUS FORMULATIONS
    2.
    发明申请
    COMPOSITIONS, METHODS AND USES FOR THERMALLY STABLE HUMAN PAPILLOMAVIRUS FORMULATIONS 审中-公开
    组合物，方法和用于热稳定人类羊毛病制剂

    公开(公告)号：US20170065707A1

    公开(公告)日：2017-03-09

    申请号：US15309169

    申请日：2015-05-06

    Applicant: The Regents of the University of Colorado, A body corporate

    Inventor： Theodore Randolph ,  Robert Garcea ,  Kimberly J. Hassett

    IPC: A61K39/12 ,  A61K45/06

    CPC classification number: A61K39/12 ,  A61K39/295 ,  A61K45/06 ,  A61K2039/5252 ,  A61K2039/55505 ,  A61K2039/55572 ,  C12N2710/20034 ,  C12N2710/20063

    Abstract: Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes.

    Abstract translation: 本发明的实施方案提供了用于制备和使用热稳定的人乳头瘤病毒（HPV）制剂或其它稳定的多聚体病毒制剂的新型组合物和方法。 某些实施方案涉及在存在或不存在佐剂的情况下冻干HPV制剂。 其他实施方案涉及使用HPV疫苗疫苗，以提高免疫原性组合物对于HPV感染的储存，递送和使用的稳定性。 在其它实施方案中，单个免疫原性组合物可以包括多种病毒血清型的热稳定制剂。

    COMPOSITIONS, METHODS AND USES FOR THERMALLY STABLE MULTI-TARGETED ANTIGENS
    3.
    发明申请
    COMPOSITIONS, METHODS AND USES FOR THERMALLY STABLE MULTI-TARGETED ANTIGENS 有权

    公开(公告)号：US20220175907A1

    公开(公告)日：2022-06-09

    申请号：US17665285

    申请日：2022-02-04

    Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

    Inventor： Theodore Randolph ,  Robert Garcea ,  Kimberly J. Hassett

    IPC: A61K39/12 ,  A61K39/295 ,  A61K45/06

    Abstract: Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes. Yet other embodiments disclosed herein concern multi-targeted antigen complexes lyophilized in formulations of use to prolong stability and/or enhance immunogenicity. Other embodiments concern exposing lyophilized multi-targeted antigen complexes to elevated temperatures to enhance immunogenicity of the antigens of the complex to multiple pathogens.

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