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公开(公告)号：US3868364A
公开(公告)日：1975-02-25
申请号：US18492171
申请日：1971-09-29
发明人： ISHIMARU TOSHIYASU , KODAMA YUTAKA
IPC分类号： C07D499/00 , C07D499/12 , C07D99/16
CPC分类号： C07D499/00 , Y02P20/55
摘要： Penicillin is prepared in an industrially advantageous manner by reacting 6-amino-penicillanic acid with silylhalides, to protect the carboxyl group of the 6-aminopenicillanic acid, by forming a mixed acid anhydride grouping, then reacting the above obtained product in the presence of an acid-binding agent with reactive derivatives of carboxylic acid, and then solvolyzing the product to remove the protecting group of the carboxy group to form penicillin.
摘要翻译： 通过使6-氨基 - 青霉烷酸与甲硅烷基卤化物反应，通过形成混合酸酐组，然后在上述获得的产物存在下使上述获得的产物反应，从而保护6-氨基青霉烷酸的羧基，以工业上有利的方式制备青霉素 酸结合剂与羧酸的反应性衍生物反应，然后溶剂化产物以除去羧基的保护基以形成青霉素。
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公开(公告)号：US3867371A
公开(公告)日：1975-02-18
申请号：US26714772
申请日：1972-06-28
发明人： ISHIMARU TOSHIYASU , KODAMA YUTAKA
IPC分类号： C07D499/00 , C07D499/04 , C07D499/32 , C07F9/14 , C07D99/16
CPC分类号： C07D499/00 , C07F9/14
摘要： Penicillin or penicillin sulfoxide esters are prepared in an industrially advantageous manner, by reacting an N,Ndisubstituted acid amide with a halogenating agent, reacting the thus obtained product with a salt of penicillin or penicillin sulfoxide, and then reacting the product with an hydroxy compound in the presence of an acid-binding agent.
摘要翻译： 通过使N，N-二取代的酰胺与卤化剂反应，使由此得到的产物与青霉素或青霉素亚砜的盐反应，然后使产物与羟基反应，使产物与羟基反应，从而以工业上有利的方式制备青霉素或青霉素亚砜酯。 化合物在酸结合剂存在下进行。
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公开(公告)号：US3896118A
公开(公告)日：1975-07-22
申请号：US18791071
申请日：1971-10-08
发明人： ISHIMARU TOSHIYASU , KODAMA YUTAKA
IPC分类号： C07D501/04 , A61K20060101 , A61K31/545 , C07D20060101 , C07D501/18 , C07D501/60 , C07D99/24
CPC分类号： C07D501/18
摘要： 7-Aminocephalosporanic acids have been prepared in an industrially advantageous manner, by reacting 7aminocephalosporanic acids with a halogenated compound, represented by the formula (III-1) to (III-4), in the presence of an acid-binding agent, to protect the carboxy group of the said 7-acylamidocephalosporanic acid derivatives, by forming a mixed acid anhydride grouping, converting the reaction product into the corresponding imino halide by further reaction with an imino halide-forming reagent, converting the resultant imino halide into the corresponding iminoether, and removing the protecting group of the carboxyl group to form 7-aminocephalosporanic acids.
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公开(公告)号：US3629378A
公开(公告)日：1971-12-21
申请号：US3629378D
申请日：1968-09-11
发明人： KODAMA YUTAKA , KODAMA TSUTOMU , NAKABAYASHI MASAO
摘要： SELECTIVE SEPARATION OF THE TRI-SUBSTITUTED HYDROCARBYL PHOSPHATES ONLY BY EXTRACTION FROM AN AQUEOUS SOLUTION OF WATER-SOLUBLE TRI-SUBSTITUTED HYDROCARBYL PHOSPHATES OF THE FORMULA (RO)2P(O)(OR'') WHEREIN R IS AN ALKYL OR ALKENYL GROUP HAVING 1 TO 3 CARBON ATOMS OR SAID GROUPS SUBSTITUTED BY CHLORINE AND R'' IS AN ALKYL OR ALKENYL GROUP HAVING 1 TO 4 CARBON ATOMS OR SAID GROUPS SUBSITUTED BY CHLORINE. THE COMPOUNDS ARE USEFUL AS ADDITIVES FOR GASOLINE, PLASTICIZERS FOR THERMOPLASTIC RESINS AND FLAME RETARDING AGENTS FOR RIGID POLYURETHANE FOAM, POLYESTER RESIN, ETC.
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公开(公告)号：US3876630A
公开(公告)日：1975-04-08
申请号：US33829473
申请日：1973-03-05
发明人： ISHIMARU TOSHIYASU , KODAMA YUTAKA
IPC分类号： C07D499/04 , C07D499/00 , C07D499/08 , C07D499/32 , C07D99/16 , C07D99/22
CPC分类号： C07D499/00
摘要： Penicillin esters are produced by reacting penicillin derivatives with organic sulfonylhalides and organic hydroxy compounds in the presence of an acid-binding agent.
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公开(公告)号：US3864340A
公开(公告)日：1975-02-04
申请号：US31871472
申请日：1972-12-27
发明人： ISHIMARU TOSHIYASU , KODAMA YUTAKA
IPC分类号： C07D20060101 , C07D205/00 , C07D279/00 , C07D501/00 , C07D501/04 , C07D501/06 , C07D501/20 , C07D501/40 , C07D501/60 , C07D99/24
CPC分类号： C07D501/20 , Y02P20/55
摘要： 7-ACYLAMIDE-3-CEPHEM-4-CARBOXYLIC ACIDS ARE PREPARED IN AN INDUSTRIALLY ADVANTAGEOUS MANNER, BY REACTING A 7-AMINO-3-CEPHAM4-CARBOXYLIC ACID WITH THE REACTIVE DERIVATIVES OF A CARBOXYLIC ACIDS IN THE PRESENCE OF ALCOHOLS, AS A SOLVENT, AND THEREAFTER, IF NECESSARY, REMOVING THE PROTECTING GROUP FOR THE AMINO GROUP OF THE ABOVE-OBTAINED PRODUCTS.
摘要翻译： 通过在醇，AS中存在的羧酸与羧酸的反应性衍生物反应7-氨基-3-碳
酸-4-羧酸，在工业上有利于制备7-酰亚胺-3-羧基-4-羧酸 如有必要，请撤销上述获得产品的AMINO集团保护集团的SOLVENT和其他方式。-
7.发明授权
公开(公告)号：US3890314A
公开(公告)日：1975-06-17
申请号：US38635573
申请日：1973-08-07
发明人： ISHIMARU TOSHIYASU , KODAMA YUTAKA
IPC分类号： B01J31/00 , C07B61/00 , C07D501/10 , C07D501/20 , C07D501/22 , C07D99/24
CPC分类号： C07D501/10
摘要： A 7-Acylamino-3-methyl-3-cephem-4-carboxylic acid is prepared by first forming a 7-acylamino-3-methyl-3-cephem-4-carboxylic acid ester by heating a 6-acyl-aminopenicillanic acid ester S-oxide in the presence of a catalyst consisting of an acid and a sulfide and then deesterifying the intermediate 7-acylamino-3-methyl-3cephem-4-carboxylic acid ester.
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公开(公告)号：US3699188A
公开(公告)日：1972-10-17
申请号：US3699188D
申请日：1970-03-31
CPC分类号： C07F9/02 , C07F7/045 , C08K5/5406 , Y10S521/906 , Y10S521/907
摘要： Novel organic phosphorosilicon compounds are silicate of Alpha -hydroxyphosphonate prepared by reacting a phosphorous acid triester, a carbonyl compound and a silicon compound containing at least one active chlorine atom and are effective as flameretarding agent for inflammable high polymers, particularly synthetic resins, synthetic rubbers and paints.
摘要翻译： 新型有机磷硅化合物是通过使亚磷酸三酯，羰基化合物和含有至少一个活性氯原子的硅化合物反应制备的α-羟基膦酸盐的硅酸盐，并且作为易燃高分子，特别是合成树脂，合成树脂的阻燃剂是有效的 橡胶和油漆。
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公开(公告)号：US3704335A
公开(公告)日：1972-11-28
申请号：US3704335D
申请日：1969-07-25
发明人： KODAMA YUTAKA , TAKAI AKIRA , INAGAKI TATSUMI
CPC分类号： A23K50/30 , A23K20/116
摘要： 3-DI(HYDROXYMETHYL) AMINO - 6(5-NITRO - 2-FURYLETHENYL)- 1,2,4-TRIAZINE IS VERY EFFECTIVE FOR PROMOTING THE GROWTH OF LIVESTOCK (FOR EXAMPLE, POULTRY, DUCKS, TURKEYS, SWINE, HORSES, CATTLE AND GOATS) WHEN GIVEN TO THE LIVESTOCK IN COMBINATION WITH CARRIERS SUCH AS FEEDS AND INERT MINERALS.
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公开(公告)号：US3591664A
公开(公告)日：1971-07-06
申请号：US3591664D
申请日：1968-09-11
发明人： KODAMA YUTAKA , KODAMA TSUTOMU , NAKABAYASHI MASAO
CPC分类号： C10L1/2641 , C07F9/08
摘要： PREPARATION OF TRI-SUBSTITUTED HYDROCARBYL PHOSPHATES, BY REACTING DIHYDROCARBYLCHLOROPHOSPHATES WITH ALCOHOLS IN THE PRESENCE OF CAUSTIC ALKALIS, SUCH AS CAUSTIC SODA AND CAUSTIC POTASH, ETC., WHEREBY THE HYDROEN CHLORIDE FORMED SIMULTANEOUSLY IS NEUTRALIZED QUICKLY WITH THE CAUSTIC ALKALI. ACCORDING TO THIS PROCESS, IT IS POSSIBLE NOT ONLY TO PREVENT THE DECOMPOSITION OF DIHYDROCARBYLCHLOROPHOSPHATES BUT ALSO TO SUPPRESS THE SIDE REACTION REPRESENTED BY THE EQUATION:
(RO)3PO+HCL-->(RO)2P(O)OH+RIL
WHEREIN R IS AN ALKYL GROUP. THE COMPOUNDS PRODUCED BY THE INVENTION ARE USEFUL AS ADDITIVES FOR GASOLINE, PLASTICIZERS FOR THERMOPLASTIC RESINS AND FLAME RETARDING AGENTS FOR RIGID POLYURETHANE FOAM, POLYESTER RESIN, ETC.
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