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公开(公告)号：US11266768B2
公开(公告)日：2022-03-08
申请号：US15039136
申请日：2014-11-26
发明人： Mark Grinstaff , Jonah Andrew Kaplan , Julia Wang
IPC分类号： A61K9/26 , A61L31/14 , A61L27/34 , A61L27/50 , A61L27/54 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/16 , A61K9/51 , A61K9/50
摘要： The disclosure provides a drug delivery device that can release a drug or other molecule of interest in response to application of a mechanical force, such as tension, and methods of use thereof. The present disclosure provides a tension-responsive drug delivery device by exploiting a difference in mechanical properties between a drug-loaded core material and a supertiydrophobic barrier coating consisting of interconnected micro- and nano-sized particles formulated via the electrospraying of a mixture of biocompatible polymers.
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公开(公告)号：US20160169864A1
公开(公告)日：2016-06-16
申请号：US14895714
申请日：2014-05-30
发明人： Mark Grinstaff , Amit Meller , Joseph Hersey , Allison Squires
IPC分类号： G01N33/487 , B05D1/00 , G01N27/447
CPC分类号： G01N33/48721 , B05D1/007 , C08J7/047 , C08J2309/02 , C08J2477/02 , C12Q1/6825 , G01N27/44747 , G01N27/44791 , C12Q2565/631
摘要： Provided herein are compositions, compounds, processes, and methods of use of 3D porous coating(s) on or near a nanopore(s) for analysis or detection of charged polymers such as nucleic acids, proteins, protein-nucleic acid complexes, small molecule-biological complexes, polymer-biological complexes, and/or polyelectrolytes.
摘要翻译： 本文提供了用于分析或检测带电聚合物如核酸，蛋白质，蛋白质 - 核酸复合物，小分子的纳米孔上或附近的三维多孔涂层的组合物，化合物，方法和方法 生物复合物，聚合物 - 生物复合物和/或聚电解质。
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公开(公告)号：US20190282665A1
公开(公告)日：2019-09-19
申请号：US16339659
申请日：2017-10-09
发明人： Ara Nazarian , Edward Rodriguez , Mark Grinstaff
摘要： The present invention provides methods for treating a stiffened joint in a subject that comprise administering relaxin, e.g., a PEGylated relaxin-2, to the subject. The relaxin may be administered intra-articularly as a sustained release formulation. The present invention also provides sustained release formulations in the form of a hydrogel for administering polypeptides that are covalently attached to a polymer, e.g., PEG.
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公开(公告)号：US20190224336A1
公开(公告)日：2019-07-25
申请号：US16252927
申请日：2019-01-21
发明人： Orian Shirihai , Mark Grinstaff , Jialiu Zeng
摘要： In various embodiments novel biodegradable acid-activated acid releasing nanoparticles (acNPs) are provided that are used as a targeted strategy to manipulate lysosomal acidity and autophagy. These acNPs based, in certain embodiments, on fluorinated polyesters are degraded at pH 6.0 (pH reported in dysfunctional lysosomes), and release component acids that further lower the lysosomal pH, and thereby increasing autophagic flux and cellular function of hepatocytes under LT. The acNPs can serve as a therapeutic in restoring liver-diseases.
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公开(公告)号：US11360104B2
公开(公告)日：2022-06-14
申请号：US16209678
申请日：2018-12-04
申请人： TRUSTEES OF BOSTON UNIVERSITY , L'UNIVERSITÉ DE BORDEAUX , L'INSTITUT POLYTECHNIQUE DE BORDEAUX , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人： James Galagan , Allison Dennis , Catherine Klapperich , Mark Grinstaff , Thuy Nguyen , R. Baer , Uros Kuzmanovic , Marjon Zamani , Mingfu Chen , Margaret Chern , Chloe Grazon
IPC分类号： G01N33/74 , C07K14/245 , G01N33/566 , G01N33/542 , C07K14/195 , C12N9/00 , C07K14/34 , C12N9/22
摘要： Described herein are methods, compositions and processes related to a microbial-based biosensor system for the detection of small molecules and analytes based on an analyte-responsive transcription factor-DNA binding mechanism with either a ratiometric fluorescent output through Förster resonance energy transfer (FRET) or a redox sensor output for the quantification of the target analyte with high sensitivity.
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公开(公告)号：US09872936B2
公开(公告)日：2018-01-23
申请号：US15159184
申请日：2016-05-19
IPC分类号： A61K9/08 , A61L27/52 , A61L27/18 , C08F220/28 , C08F230/02 , C08L43/02 , A61L27/50 , A61L27/54 , A61K9/06
CPC分类号： A61L27/18 , A61K9/06 , A61L27/50 , A61L27/52 , A61L27/54 , A61L2400/06 , A61L2400/10 , A61L2430/06 , A61L2430/34 , C08F220/28 , C08F230/02 , C08L43/02 , C08F2222/1013 , C08F2220/387
摘要： The present invention provides polymers which can be used as tissue supplements or lubricants in vivo. The inventive polymers can be used as tissue-interpenetrating hydrogel supplements, viscosupplements, tribosupplements, viscoelastics, tissue space fillers, and/or anti-adhesive agents. Also provided are pharmaceutical compositions comprising the inventive polymers and methods of using them including, for example, in the treatment of arthritic and injured synovial joints; in reconstruction or cosmetic procedures, intervertebral disc repair, treatment of vocal cord problems, treatment of urinary incontinence, and prevention of adhesion formation following abdominal or gynecological surgery or malfunction of naturally lubricious mucosal tissue.
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公开(公告)号：US20230039987A1
公开(公告)日：2023-02-09
申请号：US17868656
申请日：2022-07-19
IPC分类号： A61K31/75 , A61K31/785 , A61K31/795 , A61K31/765 , A61K9/06
摘要： Methods of forming a gel and related methods of treating subjects with such gels are described. The method may include preparing a composition by combining a macromer comprising a first polyethylene glycol (PEG)-based polymer, a poly(ethylenimine)-based polymer, or a poly(1,2-glycerol) carbonate-based polymer, the macromer including at least one first functional moiety, a crosslinking agent comprising a second PEG-based polymer that includes at least one second functional moiety, and a photoinitiator, and activating the photoinitiator via a light source to form the gel.
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公开(公告)号：US10925975B2
公开(公告)日：2021-02-23
申请号：US16252927
申请日：2019-01-21
发明人： Orian Shirihai , Mark Grinstaff , Jialiu Zeng
摘要： In various embodiments novel biodegradable acid-activated acid releasing nanoparticles (acNPs) are provided that are used as a targeted strategy to manipulate lysosomal acidity and autophagy. These acNPs based, in certain embodiments, on fluorinated polyesters are degraded at pH 6.0 (pH reported in dysfunctional lysosomes), and release component acids that further lower the lysosomal pH, and thereby increasing autophagic flux and cellular function of hepatocytes under LT. The acNPs can serve as a therapeutic in restoring liver-diseases.
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公开(公告)号：US10821204B2
公开(公告)日：2020-11-03
申请号：US15840302
申请日：2017-12-13
IPC分类号： A61L27/18 , A61L27/50 , A61L27/54 , C08L43/02 , C08F220/28 , C08F230/02 , A61L27/52 , A61K9/06
摘要： The present invention provides polymers which can be used as tissue supplements or lubricants in vivo. The inventive polymers can be used as tissue-interpenetrating hydrogel supplements, viscosupplements, tribosupplements, viscoelastics, tissue space fillers, and/or anti-adhesive agents. Also provided are pharmaceutical compositions comprising the inventive polymers and methods of using them including, for example, in the treatment of arthritic and injured synovial joints; in reconstruction or cosmetic procedures, intervertebral disc repair, treatment of vocal cord problems, treatment of urinary incontinence, and prevention of adhesion formation following abdominal or gynecological surgery or malfunction of naturally lubricious mucosal tissue.
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