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    Quadruplex stabilizer
    1.
    发明申请
    Quadruplex stabilizer 审中-公开
    四重稳定剂

    公开(公告)号：US20050249669A1

    公开(公告)日：2005-11-10

    申请号：US11131905

    申请日：2005-05-17

    Applicant: Ta-Chau Chang ,  Cheng-Chung Chang

    Inventor： Ta-Chau Chang ,  Cheng-Chung Chang

    IPC: A61K31/4178 ,  A61K31/4439 ,  A61K31/501 ,  A61K49/00 ,  C07D401/14 ,  C07D403/14 ,  C12Q1/00

    CPC classification number: C07D401/14 ,  C07D403/14 ,  G01N1/30 ,  G01N33/5091 ,  G01N2800/7028

    Abstract: This invention relates to a method for detecting cancer cells in a subject. The method includes contacting a plurality of cells in a sample obtained from the subject with carbazole compounds of the following formula: and calculating the percentage of the cells that emit florescence upon irradiation with an excitation light, in which, if the percentage is above a pre-set value, the subject is determined to contain cancer cells. In the above formula, each of rings A and B, independently, is heteroaryl containing at least one nitrogen atom; each of X and Y, independently, is CH or N; each of R1—R6, independently, is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C3-C8 heterocycloalkyl, aryl, heteroaryl, OH, C1-C6 alkoxy, aryloxy, heteroaryloxy, NH2, C1l-C6 alkylamino, C1-C12 dialkylamino, arylamino, diarylamino, or halogen; R7 is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C3-C8 heterocycloalkyl, aryl, heteroaryl; and each of m and n, independently, is 1, 2, or 3.

    Abstract translation: 本发明涉及一种用于检测受试者中癌细胞的方法。 该方法包括使得自受试者获得的样品中的多个细胞与下式的咔唑化合物接触：计算在用激发光照射时发出荧光的细胞的百分比，其中如果百分比高于预先 确定值，确定受试者含有癌细胞。 在上式中，环A和B各自独立地为含有至少一个氮原子的杂芳基; X和Y各自独立地是CH或N; R 1 -R 6中的每一个独立地是H，C 1 -C 8烷基，C 1 -C 6烷基， C 2 -C 8亚烷基，C 2 -C 8炔基，C 3 - C 8环烷基，C 3 -C 8杂环烷基，芳基，杂芳基，OH，C 1 -C 3烷基， C 1 -C 6烷氧基，芳氧基，杂芳氧基，NH 2，C 1 -C 6烷基氨基，C 1〜 C 1 -C 12二烷基氨基，芳基氨基，二芳基氨基或卤素; R 7是H，C 1 -C 8烷基，C 2 -C 8烷基，C 2 -C 8烷基， 亚烷基，C 2 -C 8炔基，C 3 -C 8环烷基，C 1 -C 3烷基， 杂环烷基，芳基，杂芳基; m和n各自独立地为1,2或3。

    Cancer cell detecting devices
    2.
    发明申请
    Cancer cell detecting devices 有权
    癌细胞检测装置

    公开(公告)号：US20070098233A1

    公开(公告)日：2007-05-03

    申请号：US11582867

    申请日：2006-10-18

    Applicant: Ta-Chau Chang ,  Cheng-Chung Chang ,  Chi-Chih Kang ,  Ji-Yen Cheng

    Inventor： Ta-Chau Chang ,  Cheng-Chung Chang ,  Chi-Chih Kang ,  Ji-Yen Cheng

    IPC: G06K9/00 ,  C12Q1/00

    CPC classification number: G01N21/6428

    Abstract: This invention relates to a device for detecting cancer cells. The device includes a light source for generating light (e.g., a light emitting diode), a first optical filter selected from the group consisting of a band pass filter and a long pass filter, a second optical filter (i.e., a band pass filter) disposed between the light source and the first optical filter, and a sample receiver for receiving a sample. The sample receiver is disposed between the first and second optical filters. The first optical filter, the sample receiver, and the second optical filter are aligned so that light emitted from the light source passes sequentially through the second optical filter, the sample receiver, and the first optical filter.

    Abstract translation: 本发明涉及一种用于检测癌细胞的装置。 该装置包括用于产生光的光源（例如，发光二极管），从由带通滤波器和长通滤波器组成的组中选择的第一滤光器，第二滤光器（即，带通滤光器） 设置在光源和第一滤光器之间，以及用于接收样品的样品接收器。 样品接收器设置在第一和第二滤光器之间。 对准第一滤光器，样品接收器和第二滤光器，使得从光源发射的光顺序地通过第二滤光器，样品接收器和第一滤光器。

    Cancer cell detecting devices
    4.
    发明授权
    Cancer cell detecting devices 有权
    癌细胞检测装置

    公开(公告)号：US07691624B2

    公开(公告)日：2010-04-06

    申请号：US11582867

    申请日：2006-10-18

    Applicant: Ta-Chau Chang ,  Cheng-Chung Chang ,  Chi-Chih Kang ,  Ji-Yen Cheng

    Inventor： Ta-Chau Chang ,  Cheng-Chung Chang ,  Chi-Chih Kang ,  Ji-Yen Cheng

    IPC: C12M1/34 ,  C12M3/00

    CPC classification number: G01N21/6428

    Abstract: This invention relates to a device for detecting cancer cells. The device includes a light source for generating light (e.g., a light emitting diode), a first optical filter selected from the group consisting of a band pass filter and a long pass filter, a second optical filter (i.e., a band pass filter) disposed between the light source and the first optical filter, and a sample receiver for receiving a sample. The sample receiver is disposed between the first and second optical filters. The first optical filter, the sample receiver, and the second optical filter are aligned so that light emitted from the light source passes sequentially through the second optical filter, the sample receiver, and the first optical filter.

    Abstract translation: 本发明涉及一种用于检测癌细胞的装置。 该装置包括用于产生光的光源（例如，发光二极管），从由带通滤波器和长通滤波器组成的组中选择的第一滤光器，第二滤光器（即，带通滤光器） 设置在光源和第一滤光器之间，以及用于接收样品的样品接收器。 样品接收器设置在第一和第二滤光器之间。 对准第一滤光器，样品接收器和第二滤光器，使得从光源发射的光顺序地通过第二滤光器，样品接收器和第一滤光器。

    Quadruplex stabilizer
    6.
    发明授权
    Quadruplex stabilizer 有权
    四重稳定剂

    公开(公告)号：US06979738B2

    公开(公告)日：2005-12-27

    申请号：US10690984

    申请日：2003-10-22

    Applicant: Ta-Chau Chang ,  Cheng-Chung Chang ,  Jin-Yi Wu

    Inventor： Ta-Chau Chang ,  Cheng-Chung Chang ,  Jin-Yi Wu

    IPC: A61K31/4178 ,  A61K31/4439 ,  A61K31/501 ,  A61K49/00 ,  C07D401/14 ,  C07D403/14 ,  C12Q1/00

    CPC classification number: C07D403/14 ,  C07D401/14

    Abstract: This invention relates to carbazole compounds of the following formula: In the above formula, each of rings A and B, independently, is heteroaryl containing at least one nitrogen atom; each of X and Y, independently, is CH or N; each of R1–R6, independently, is H, C1–C8 alkyl, C2–C8 alkenyl, C2–C8 alkynyl, C3–C8 cycloalkyl, C3–C8 heterocycloalkyl, aryl, heteroaryl, OH, C1–C6 alkoxy, aryloxy, heteroaryloxy, NH2, C1–C6 alkylamino, C1–C12 dialkylamino, arylamino, diarylamino, or halogen; R7 is H, C1–C8 alkyl, C2–C8 alkenyl, C2–C8 alkynyl, C3–C8 cycloalkyl, C3–C8 heterocycloalkyl, aryl, heteroaryl; and

    Abstract translation: 本发明涉及下式的咔唑化合物：在上式中，环A和B各自独立地为含有至少一个氮原子的杂芳基; X和Y各自独立地是CH或N; R 1 -R 6中的每一个独立地是H，C 1 -C 8烷基，C 1 -C 6烷基， C 2 -C 8亚烷基，C 2 -C 8炔基，C 3 - C 8环烷基，C 3 -C 8杂环烷基，芳基，杂芳基，OH，C 1 -C 3烷基， 烷氧基，芳氧基，杂芳氧基，NH 2，C 1 -C 6烷基氨基，C 1 -C 6烷基氨基， C 1 -C 12二烷基氨基，芳基氨基，二芳基氨基或卤素; R 7是H，C 1 -C 8烷基，C 2 -C 8烷基，C 2 -C 8烷基， 亚烷基，C 2 -C 8炔基，C 3 -C 8环烷基，C 1 -C 3烷基， 杂环烷基，芳基，杂芳基; 和m和n各自独立地是1,2或3。

    Quadruplex stabilizer
    7.
    发明申请
    Quadruplex stabilizer 有权
    四重稳定剂

    公开(公告)号：US20050090671A1

    公开(公告)日：2005-04-28

    申请号：US10690984

    申请日：2003-10-22

    Applicant: Ta-Chau Chang ,  Cheng-Chung Chang ,  Jin-Yi Wu

    Inventor： Ta-Chau Chang ,  Cheng-Chung Chang ,  Jin-Yi Wu

    IPC: A61K31/4178 ,  A61K31/4439 ,  A61K31/501 ,  A61K49/00 ,  C07D401/14 ,  C07D403/14 ,  C12Q1/00 ,  C07D43/14

    CPC classification number: C07D403/14 ,  C07D401/14

    Abstract: This invention relates to carbazole compounds of the following formula: In the above formula, each of rings A and B, independently, is heteroaryl containing at least one nitrogen atom; each of X and Y, independently, is CH or N; each of R1-R6, independently, is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C3-C8 heterocycloalkyl, aryl, heteroaryl, OH, C1-C6 alkoxy, aryloxy, heteroaryloxy, NH2, C1-C6 alkylamino, C1-C12 dialkylamino, arylamino, diarylamino, or halogen; R7 is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C3-C8 heterocycloalkyl, aryl, heteroaryl; and each of m and n, independently, is 1, 2, or 3.

    Abstract translation: 本发明涉及下式的咔唑化合物：在上式中，环A和B各自独立地为含有至少一个氮原子的杂芳基; X和Y各自独立地是CH或N; R 1 -R 6中的每一个独立地是H，C 1 -C 8烷基，C 1 -C 6烷基， C 2 -C 8亚烷基，C 2 -C 8炔基，C 3 - C 8环烷基，C 3 -C 8杂环烷基，芳基，杂芳基，OH，C 1 -C 3烷基， 烷氧基，芳氧基，杂芳氧基，NH 2，C 1 -C 6烷基氨基，C 1 -C 6烷基氨基， C 1 -C 12二烷基氨基，芳基氨基，二芳基氨基或卤素; R 7是H，C 1 -C 8烷基，C 2 -C 8烷基，C 2 -C 8烷基， 亚烷基，C 2 -C 8炔基，C 3 -C 8环烷基，C 1 -C 3烷基， 杂环烷基，芳基，杂芳基; m和n各自独立地为1,2或3。

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