利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

10 条记录 (耗时 0.039 秒)

    Benzamidine derivatives
    7.
    发明授权
    Benzamidine derivatives 失效
    苄脒衍生物

    公开(公告)号：US06784191B2

    公开(公告)日：2004-08-31

    申请号：US10164623

    申请日：2002-06-10

    申请人： Kaoru Yoshida ,  Tadakiyo Nakagawa ,  Takashi Kayahara

    发明人： Kaoru Yoshida ,  Tadakiyo Nakagawa ,  Takashi Kayahara

    IPC分类号： A61K31445

    CPC分类号： C07F9/65583 ,  C07F9/572 ,  C07F9/59

    摘要： A benzamidine derivative of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an effect of inhibiting the blood coagulation based on their excellent effect of inhibiting activated blood-coagulation factor X. Thus, a blood-coagulation inhibitor or an agent for preventing or treating thrombosis or embolism, containing one of those compounds as the active ingredient, is provided.

    摘要翻译： 下式的苯甲脒衍生物及其类似物及其药学上可接受的盐具有抑制活化凝血因子X的优异效果来抑制凝血的作用。因此，凝血抑制剂或用于预防或 提供了含有这些化合物之一作为活性成分的血栓形成或栓塞。

    Process for producing subunit peptide originating in polymer protein
    8.
    发明授权
    Process for producing subunit peptide originating in polymer protein 失效
    用于产生源自聚合物蛋白质的亚单位肽的方法

    公开(公告)号：US07270972B1

    公开(公告)日：2007-09-18

    申请号：US09926256

    申请日：2000-03-31

    申请人： Naoyuki Fukuchi ,  Shunsuke Kageyama ,  Morikazu Kito ,  Takashi Kayahara ,  Hiroshi Yamamoto

    发明人： Naoyuki Fukuchi ,  Shunsuke Kageyama ,  Morikazu Kito ,  Takashi Kayahara ,  Hiroshi Yamamoto

    IPC分类号： C12Q1/56 ,  A61K38/00

    CPC分类号： C07K14/46

    摘要： It is provided a method for producing a subunit peptide originating from an oligomeric protein having disulfide bonds within a subunit and between subunits. The method comprises producing a subunit originating from an oligomeric protein having disulfide bonds within a subunit and between subunits by the following steps: (a) a step of refolding the subunit by denaturing the oligomeric protein or its subunit in a solution with a protein-denaturing agent and removing the denaturing agent from the solution in the presence of polyoxyalkyl polyether having a functional group that reacts with a thiol group; and (b) a step of isolating the subunit bonded to the polyoxyalkyl polyether from the solution.

    摘要翻译： 提供了一种用于产生源自在亚基内和亚单位之间具有二硫键的寡聚蛋白质的亚单位肽的方法。 该方法包括通过以下步骤产生源自亚基内和亚基之间具有二硫键的寡聚蛋白的亚基：（a）通过使蛋白质变性的溶液中的寡聚蛋白质或其亚基变性来重新折叠亚基的步骤 在具有与硫醇基反应的官能团的聚氧烷基聚醚的存在下从溶液中除去变性剂; 和（b）从溶液中分离与聚氧烷基聚醚键合的亚基的步骤。

    Protein having antithrombotic activity and method for producing the same
    10.
    发明授权
    Protein having antithrombotic activity and method for producing the same 失效
    具有抗血栓形成活性的蛋白质及其制造方法

    公开(公告)号：US06710031B2

    公开(公告)日：2004-03-23

    申请号：US09969763

    申请日：2001-10-04

    申请人： Naoyuki Fukuchi ,  Morikazu Kito ,  Takashi Kayahara ,  Fumie Futaki ,  Kohki Ishikawa ,  Eiichiro Suzuki ,  Keiko Gondoh ,  Nobuhisa Shimba ,  Naoyuki Yamada

    发明人： Naoyuki Fukuchi ,  Morikazu Kito ,  Takashi Kayahara ,  Fumie Futaki ,  Kohki Ishikawa ,  Eiichiro Suzuki ,  Keiko Gondoh ,  Nobuhisa Shimba ,  Naoyuki Yamada

    IPC分类号： A61K3846

    CPC分类号： C07K14/46 ,  C07K14/745

    摘要： A method for producing a protein having an antithrombotic activity, which comprises replacing, in a protein that has an amino acid sequence having a homology of not less than 30% to the amino acid sequence of SEQ ID NO: 1 and forms a higher order structure composed of a first &bgr; strand (&bgr;1), a first &agr; helix (&agr;1), a second &agr; helix (&agr;2), a second &bgr; strand (&bgr;2), a loop, a third &bgr; strand (&bgr;3), a fourth &bgr; strand (&bgr;4) and a fifth &bgr; strand (&bgr;5) in this order from the amino terminus, at least one amino acid residue in a region from &agr;2 to &bgr;2 and/or a region from &bgr;3 to &bgr;4 so that electric charge of the amino acid residue is changed towards positive direction.

    摘要翻译： 一种具有抗血栓形成活性的蛋白质的制造方法，其特征在于，具有与SEQ ID NO：1的氨基酸序列具有不小于30％的同源性的氨基酸序列的蛋白质，并形成高级结构 由第一β链（β1），第一α螺旋（alpha1），第二α螺旋（α2），第二β链（β2），环，第三β链（β3），第四条β链 β4）和第五个β链（β5），从氨基末端起始，α2至β2区域和/或β3至β4区域中的至少一个氨基酸残基，使得氨基酸残基的电荷为 转向正向。