专利检索 ap:("Tadakiyo Nakagawa" OR "Munetaka Tokumasu" OR "Kazumi Tashiro" OR "Mitsuo Takahashi" OR "Takashi Kayahara" OR "Shunji Takehana" OR "Yuki Kajigaya" OR "Kaoru Yoshida" OR "Kuniya Sakurai") AND inv:"Tadakiyo Nakagawa" 第 1 页

1.

发明授权
Benzodiazepine derivatives 失效
标题翻译：苯并二氮杂衍生物

公开(公告)号：US06825191B2

公开(公告)日：2004-11-30

申请号：US10397219

申请日：2003-03-27

申请人： Tadakiyo Nakagawa , Munetaka Tokumasu , Kazumi Tashiro , Mitsuo Takahashi , Takashi Kayahara , Shunji Takehana , Yuki Kajigaya , Kaoru Yoshida , Kuniya Sakurai

发明人： Tadakiyo Nakagawa , Munetaka Tokumasu , Kazumi Tashiro , Mitsuo Takahashi , Takashi Kayahara , Shunji Takehana , Yuki Kajigaya , Kaoru Yoshida , Kuniya Sakurai

IPC分类号： C07D40114

CPC分类号： C07D401/06 , A61K31/551 , A61K31/5513 , A61K31/675 , C07D243/24 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07F9/645 , C07F9/65583

摘要： The present invention provides benzodiazepine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof. The compounds of the present invention have an excellent effect of inhibiting activated blood-coagulation factor X. These compounds are usable as agents for treating various diseases concerned with the activated blood-coagulation factor X.

摘要翻译： 本发明提供下式的苯并二氮杂衍生物，其类似物和其药学上可接受的盐。本发明的化合物具有抑制活化凝血因子X的优异效果。这些化合物可用作治疗与活化凝血因子X有关的各种疾病的药剂。

2.

发明授权
Benzamidine derivative 失效
标题翻译：苄脒衍生物

公开(公告)号：US06812231B2

公开(公告)日：2004-11-02

申请号：US10073985

申请日：2002-02-14

申请人： Tadakiyo Nakagawa , Kazuyuki Sagi , Kaoru Yoshida , Yumiko Fukuda , Masataka Shoji , Shunji Takehana , Takashi Kayahara , Akira Takahara

发明人： Tadakiyo Nakagawa , Kazuyuki Sagi , Kaoru Yoshida , Yumiko Fukuda , Masataka Shoji , Shunji Takehana , Takashi Kayahara , Akira Takahara

IPC分类号： A61K31501

CPC分类号： C07D401/04 , C07C257/18 , C07D207/48 , C07D211/46 , C07D233/26 , C07D401/06 , C07D417/04 , C07F9/4015 , C07F9/4056 , C07F9/59 , C07F9/65583

摘要： Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated blood-coagulation factor X, and they are useful as agents for preventing or treating various diseases caused by thrombi or emboli.

摘要翻译： 提供下式的苄脒衍生物，其类似物和其药学上可接受的盐。这些化合物具有抑制活化凝血因子X的作用，可用作预防或治疗由血栓或栓塞引起的各种疾病的药剂。

3.

发明授权
Benzamidine derivatives 有权
标题翻译：苄脒衍生物

公开(公告)号：US06410538B2

公开(公告)日：2002-06-25

申请号：US09731729

申请日：2000-12-08

申请人： Tadakiyo Nakagawa , Kazuyuki Sagi , Kaoru Yoshida , Yumiko Fukuda , Masataka Shoji , Shunji Takehana , Takashi Kayahara , Akira Takahara

发明人： Tadakiyo Nakagawa , Kazuyuki Sagi , Kaoru Yoshida , Yumiko Fukuda , Masataka Shoji , Shunji Takehana , Takashi Kayahara , Akira Takahara

IPC分类号： A61K3150

CPC分类号： C07D401/04 , C07C257/18 , C07D207/48 , C07D211/46 , C07D233/26 , C07D401/06 , C07D417/04 , C07F9/4015 , C07F9/4056 , C07F9/59 , C07F9/65583

摘要： Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated blood-coagulation factor X, and they are useful as agents for preventing or treating various diseases caused by thrombi or emboli.

摘要翻译： 提供下式的苄脒衍生物，其类似物和其药学上可接受的盐。这些化合物具有抑制活化凝血因子X的作用，可用作预防或治疗由血栓或栓塞引起的各种疾病的药剂。

4.

发明授权
Benzamidine derivatives 失效
标题翻译：苄脒衍生物

公开(公告)号：US07396844B1

公开(公告)日：2008-07-08

申请号：US09356492

申请日：1999-07-19

申请人： Masaru Takayanagi , Kazuyuki Sagi , Tadakiyo Nakagawa , Masahiro Yamanashi , Takashi Kayahara , Shunji Takehana , Yumiko Fukuda , Mitsuo Takahashi , Masataka Shoji

发明人： Masaru Takayanagi , Kazuyuki Sagi , Tadakiyo Nakagawa , Masahiro Yamanashi , Takashi Kayahara , Shunji Takehana , Yumiko Fukuda , Mitsuo Takahashi , Masataka Shoji

IPC分类号： A61K31/155 , C07D207/14 , C07D221/02 , C07C249/02

CPC分类号： C07D207/327 , C07C257/18 , C07C279/18 , C07C311/13 , C07C311/19 , C07C327/48 , C07C2601/14 , C07D209/08 , C07D209/16 , C07D211/34 , C07D211/46 , C07D211/62 , C07D211/70 , C07D213/56 , C07D213/74 , C07D233/26 , C07D233/64 , C07D239/06 , C07D295/155 , C07D295/192 , C07D295/215 , C07D453/02 , C07F9/59

摘要： Benzamidine derivatives of the following formulae or analogs thereof, i.e., pharmaceutically acceptable salts thereof, are provided. These compounds or salts thereof have a blood-coagulation inhibiting effect based on an excellent effect of inhibiting the action of activated blood coagulation factor X, and they are useful as anticoagulants

摘要翻译： 提供了下式的苯甲脒衍生物或其类似物，即其药学上可接受的盐。这些化合物或其盐基于抑制活化凝血因子X的作用的优异效果而具有凝血抑制作用，可用作抗凝剂

5.

发明授权
Aminoisoquinoline derivatives 有权
标题翻译：氨基异喹啉衍生物

公开(公告)号：US06825181B1

公开(公告)日：2004-11-30

申请号：US09665633

申请日：2000-09-19

申请人： Tadakiyo Nakagawa , Shingo Makino , Kazuyuki Sagi , Masaru Takayanagi , Takashi Kayahara , Shunji Takehana

发明人： Tadakiyo Nakagawa , Shingo Makino , Kazuyuki Sagi , Masaru Takayanagi , Takashi Kayahara , Shunji Takehana

IPC分类号： A61K3166

CPC分类号： C07D401/12 , C07D217/22 , C07D401/14

摘要： Aminoisoquinoline derivatives of the following formulae or analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an excellent effect of inhibiting activated blood-coagulation factor X, and they are useful as anticoagulants or agents for preventing or treating thrombi or emboli.

摘要翻译： 提供下式的氨基异喹啉衍生物或其类似物及其药学上可接受的盐。这些化合物具有抑制活化凝血因子X的优异效果，并且它们可用作预防或治疗血栓或栓塞的抗凝剂或药剂。

6.

发明授权
Benzamidine derivatives 失效
标题翻译：苄脒衍生物

公开(公告)号：US06784191B2

公开(公告)日：2004-08-31

申请号：US10164623

申请日：2002-06-10

申请人： Kaoru Yoshida , Tadakiyo Nakagawa , Takashi Kayahara

发明人： Kaoru Yoshida , Tadakiyo Nakagawa , Takashi Kayahara

IPC分类号： A61K31445

CPC分类号： C07F9/65583 , C07F9/572 , C07F9/59

摘要： A benzamidine derivative of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an effect of inhibiting the blood coagulation based on their excellent effect of inhibiting activated blood-coagulation factor X. Thus, a blood-coagulation inhibitor or an agent for preventing or treating thrombosis or embolism, containing one of those compounds as the active ingredient, is provided.

摘要翻译： 下式的苯甲脒衍生物及其类似物及其药学上可接受的盐具有抑制活化凝血因子X的优异效果来抑制凝血的作用。因此，凝血抑制剂或用于预防或提供了含有这些化合物之一作为活性成分的血栓形成或栓塞。