公开(公告)号：US08518651B2

公开(公告)日：2013-08-27

申请号：US12527191

申请日：2008-02-15

申请人： Taka-aki Sato ,  Atsuhiko Toyama ,  Takashi Shimada ,  Tetsuyoshi Sugita ,  Daisuke Aoki ,  Atsushi Suzuki ,  Nobuyuki Susumu ,  Hiroyuki Nomura

发明人： Taka-aki Sato ,  Atsuhiko Toyama ,  Takashi Shimada ,  Tetsuyoshi Sugita ,  Daisuke Aoki ,  Atsushi Suzuki ,  Nobuyuki Susumu ,  Hiroyuki Nomura

IPC分类号： G01N33/53

CPC分类号： G01N33/57449 ,  G01N2800/56

摘要： It is provided a method for identification of the morbidity of epithelial ovarian cancer based on a tissue-type in view of molecular typing which is different from a conventional histopathology, and a marker for identification of a tissue-type of epithelial ovarian cancer. A method for identification of the morbidity of epithelial ovarian cancer based on a tissue-type, comprising: subjecting a sample originated from an individual of interest to a treatment for detecting at least one selected from the group consisting of biological molecules specifically showing an upregulation in expression in a specific tissue-type of epithelial ovarian cancer, and/or at least one selected from the group consisting of biological molecules specifically showing a downregulation in expression in a specific tissue-type of epithelial ovarian cancer, and identifying whether or not the significant detection of the protein is achieved, thereby identifying the tissue-type.

摘要翻译： 提供了一种鉴定与常规组织病理学不同的分子分型的基于组织型的上皮性卵巢癌的发病率的方法和用于鉴定组织型上皮性卵巢癌的标志物。 一种用于鉴定基于组织型的上皮性卵巢癌的发病率的方法，其包括：对来自感兴趣个体的样品进行处理，以检测选自特异性显示上调的生物分子中的至少一种 在特定组织型上皮性卵巢癌中的表达，和/或选自特异性显示特定组织型上皮性卵巢癌中的下调的生物分子中的至少一种，以及鉴定是否显着 实现蛋白质的检测，从而鉴定组织型。

公开(公告)号：US20100075354A1

公开(公告)日：2010-03-25

申请号：US12527191

申请日：2008-02-15

申请人： Taka-aki Sato ,  Atsuhiko Toyama ,  Takashi Shimada ,  Tetsuyoshi Sugita ,  Daisuke Aoki ,  Atsushi Suzuki ,  Nobuyuki Susumu ,  Hiroyuki Nomura

发明人： Taka-aki Sato ,  Atsuhiko Toyama ,  Takashi Shimada ,  Tetsuyoshi Sugita ,  Daisuke Aoki ,  Atsushi Suzuki ,  Nobuyuki Susumu ,  Hiroyuki Nomura

IPC分类号： C12Q1/48 ,  C12Q1/34 ,  C12Q1/02 ,  C12N9/10 ,  C12N9/14 ,  C07K14/00

CPC分类号： G01N33/57449 ,  G01N2800/56

摘要： It is provided a method for identification of the morbidity of epithelial ovarian cancer based on a tissue-type in view of molecular typing which is different from a conventional histopathology, and a marker for identification of a tissue-type of epithelial ovarian cancer. A method for identification of the morbidity of epithelial ovarian cancer based on a tissue-type, comprising: subjecting a sample originated from an individual of interest to a treatment for detecting at least one selected from the group consisting of biological molecules specifically showing an upregulation in expression in a specific tissue-type of epithelial ovarian cancer, and/or at least one selected from the group consisting of biological molecules specifically showing a downregulation in expression in a specific tissue-type of epithelial ovarian cancer, and identifying whether or not the significant detection of the protein is achieved, thereby identifying the tissue-type.

摘要翻译： 提供了一种鉴定与常规组织病理学不同的分子分型的基于组织型的上皮性卵巢癌的发病率的方法和用于鉴定组织型上皮性卵巢癌的标志物。 一种用于鉴定基于组织型的上皮性卵巢癌的发病率的方法，其包括：对来自感兴趣个体的样品进行处理，以检测选自特异性显示上调的生物分子中的至少一种 在特定组织型上皮性卵巢癌中的表达，和/或选自特异性显示特定组织型上皮性卵巢癌中的下调的生物分子中的至少一种，以及鉴定是否显着 实现蛋白质的检测，从而鉴定组织型。

公开(公告)号：US20090246769A1

公开(公告)日：2009-10-01

申请号：US12246242

申请日：2008-10-06

申请人： Takaaki SATO ,  Tetsuyoshi Sugita ,  Atsuhiko Toyama ,  Takashi Shimada ,  Daisuke Aoki ,  Atsushi Suzuki ,  Nobuyuki Susumu ,  Hiroyuki Nomura

发明人： Takaaki SATO ,  Tetsuyoshi Sugita ,  Atsuhiko Toyama ,  Takashi Shimada ,  Daisuke Aoki ,  Atsushi Suzuki ,  Nobuyuki Susumu ,  Hiroyuki Nomura

IPC分类号： C12Q1/68 ,  C12M1/34 ,  G01N33/574

CPC分类号： G01N33/57449 ,  C12Q1/6886 ,  C12Q2600/158

摘要： A molecular diagnosis system of ovarian cancers encompasses a detection device configured to obtain a detected value of an expression amount of an apolipoprotein A1 gene in ovarian tissue as a diagnosis subject, a storage device configured to store a normal value of the expression amount of the apolipoprotein A1 gene in normal ovarian tissue, and a determination mechanism configured to determine that the ovarian tissue as the diagnosis subject is clear cell adenocarcinoma when the detected value is lower than the normal value.

摘要翻译： 卵巢癌的分子诊断系统包括：检测装置，其被配置为获得作为诊断对象的卵巢组织中载脂蛋白A1基因的表达量的检测值，存储装置，其被配置为存储载脂蛋白的表达量的正常值 A1基因在正常卵巢组织中的表达，以及确定机制，用于确定当检测值低于正常值时，作为诊断对象的卵巢组织为透明细胞腺癌。