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1.发明申请Reaction vessel, reaction apparatus and detection apparatus using the same, and method of manufacturing reaction vessel 审中-公开反应容器，反应装置及使用其的检测装置以及反应容器的制造方法公开(公告)号：US20060275892A1
公开(公告)日：2006-12-07
申请号：US11445999
申请日：2006-06-02
IPC分类号： C12M1/34
CPC分类号： G01N35/10 , B01J2219/00378 , B01J2219/00641 , B01J2219/00664 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01L3/0275 , B01L3/508 , B01L2300/0609 , B01L2300/0636 , G01N2035/1025 , G01N2035/1062
摘要： A reaction vessel includes a three-dimensional substrate on which a probe applied to detection of a biorelated substance is immobilized, a coupling portion allowed to be coupled to a liquid driver in an airtight fashion, and a solution sucking portion allowed to suck a solution. The coupling portion and the solution sucking portion are arranged with a three-dimensional substrate held between them.
摘要翻译： 反应容器包括其上固定有用于检测生物矫正物质的探针的三维基板，允许以气密方式与液体驱动器结合的联接部分和允许吸取溶液的溶液吸入部分。 联接部和溶液吸引部配置有保持在它们之间的三维基板。
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公开(公告)号：US20060116603A1
公开(公告)日：2006-06-01
申请号：US11281200
申请日：2005-11-16
申请人： Takami Shibazaki , Hiromi Sanuki
发明人： Takami Shibazaki , Hiromi Sanuki
IPC分类号： A61B10/00
CPC分类号： A61B10/0096 , A61B10/06 , A61B2010/045
摘要： A biopsy device includes an catching member that is able to catch and release a living sample, a sheath through which the catching member is able to be inserted, and a container that stores the living sample. The container includes a container portion that is able to contain a sample preservation reagent and the living sample, a first removable insertion portion connected detachably and liquid-tightly to an end portion of the sheath, through which the catching member is able to be removably inserted from an outside of the container to the container portion, and a second removable insertion portion through which the catching member is able to be removably inserted from the container portion to an outside of the container in a liquid-tight manner.
摘要翻译： 活检装置包括能够捕获和释放活体样品的捕获构件，能够插入捕获构件的护套和存储活体样品的容器。 容器包括容纳部分，其能够容纳样品保存试剂和活体样品，第一可移除插入部分，其可拆卸地和液密地连接到护套的端部，捕获构件可以通过该第一可移除插入部分可移除地插入 从容器的外部到容器部分，以及第二可移除插入部分，捕获构件能够以液体方式从容器部分可移除地插入到容器的外部。
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3.发明申请公开(公告)号：US20110060137A1
公开(公告)日：2011-03-10
申请号：US12944260
申请日：2010-11-11
申请人： Yasuo Tanigami , Kazue Nakajima , Takami Shibazaki
发明人： Yasuo Tanigami , Kazue Nakajima , Takami Shibazaki
CPC分类号： C12Q1/6806 , A61B10/0038 , A61B10/0096 , C12N15/1003 , C12N15/1006
摘要： The present invention relates to a stool sample processing method and stool sample processing container the a stool sample processing container provided with a stool collection tool, a suspending solution holding portion and a processing solution holding portion, wherein stool sample preparation solutions consisting of a suspending solution and a stool sample processing solution are respectively housed in a suspending solution holding container and a processing solution holding container, after first mixing a stool sample with the suspending solution and suspending therein, a sealant is released into the suspending solution holding container by pressing on the lower portion of the processing solution holding container, and the resulting stool suspension mixes with the stool sample processing solution that stabilizes the nucleic acid.
摘要翻译： 本发明涉及一种粪便样品处理方法和粪便样品处理容器，该粪便样品处理容器设置有粪便收集工具，悬浮液保持部分和处理溶液保持部分，其中粪便样品制备溶液由悬浮液 和粪便样品处理溶液分别容纳在悬浮液保持容器和处理液保持容器中，首先将粪便样品与悬浮液混合并悬浮在其中后，将密封剂按压在悬浮液保持容器中 处理液保持容器的下部，并且所得到的粪便悬浮液与稳定核酸的粪便样品处理溶液混合。
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4.发明申请Gene examining apparatus and method of detecting target nucleic acid using the same 审中-公开检测靶核酸的基因检测装置及方法公开(公告)号：US20070134712A1
公开(公告)日：2007-06-14
申请号：US11655316
申请日：2007-01-19
CPC分类号： B01L3/50255 , B01J2219/00608 , B01J2219/00612 , B01J2219/00641 , B01J2219/00722 , B01L2300/0819 , B01L2400/0487 , C40B40/06
摘要： The present invention relates to a gene examining apparatus utilizing a computer, the apparatus comprising (1) DNA microarrays in each of which a large number of fine liquid accommodating sections are two-dimensionally arranged so that openings of the fine liquid accommodating sections are located on the same plane, in which each of the liquid accommodating sections can three-dimensionally accommodate a liquid, and in which hybridization reaction occurs in the liquid accommodating section between a target nucleic acid already labeled with an optical marker substance and the nucleic acid probe, and (2) a microscope comprising a stage supporting the DNA microarrays set forth in (1), a temperature regulating section that regulates the temperature of each DNA microarray, and imaging means for picking up an image of an optical signal from the DNA microarray.
摘要翻译： 本发明涉及一种利用计算机的基因检查装置，该装置包括：（1）DNA微阵列，其中大量微细液体容纳部分被二维地布置成使得细液体容纳部分的开口位于 其中每个液体容纳部分可以三维地容纳液体，并且在已经用光学标记物质标记的靶核酸和核酸探针之间的液体容纳部分中发生杂交反应的同一平面，以及 （2）显微镜，其包括支持（1）中所述的DNA微阵列的阶段，调节每个DNA微阵列的温度的温度调节部和用于从DNA微阵列拾取光信号的图像的成像装置。
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公开(公告)号：US20080018778A1
公开(公告)日：2008-01-24
申请号：US11880657
申请日：2007-07-23
申请人： Yuichiro Matsuo , Takami Shibazaki , Yuko Saida
发明人： Yuichiro Matsuo , Takami Shibazaki , Yuko Saida
IPC分类号： G03B7/00
CPC分类号： G01N21/6456 , G01N21/6452
摘要： First, image capturing is performed in the exposure time of ExpStart. If the maximum intensity value of all the pixels of an image is smaller than TransStart, the exposure time is increased and the image capturing is performed again. After that, increase in the exposure time and the image capturing are repeatedly performed until the maximum intensity value of all the pixels of the captured optical image becomes equal to or greater than TransStart. When the maximum intensity value becomes equal to or greater than TransStart, image data is transferred to a computer to be recorded on the hard disk, and the number of images recorded is counted. Subsequently, the increase in the exposure time, the image capturing, transfer and record of the image data, and count of the number of images recorded are repeatedly performed. The image capturing is finished when the minimum intensity value in an area of the fluorescent image that is smaller than the entire area becomes larger than TransEnd, the number of images recorded becomes larger than TransPicts, or the exposure time becomes longer than MaxExpTime.
摘要翻译： 首先，在ExpStart的曝光时间内执行图像捕获。 如果图像的所有像素的最大强度值小于TransStart，则曝光时间增加，再次执行图像拍摄。 之后，重复执行曝光时间和图像拍摄的增加，直到拍摄的光学图像的所有像素的最大强度值变为等于或大于TransStart。 当最大强度值变得等于或大于TransStart时，将图像数据传送到计算机以记录在硬盘上，并记录所记录的图像数。 随后，重复执行曝光时间的增加，图像捕获，图像数据的传送和记录以及记录的图像数量的计数。 当荧光图像的小于整个区域的区域中的最小强度值变得大于TransEnd时，完成图像捕获，记录的图像数量变得大于TransPicts，或者曝光时间变得比MaxExpTime长。
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公开(公告)号：US07224826B2
公开(公告)日：2007-05-29
申请号：US10606518
申请日：2003-06-26
申请人： Takami Shibazaki , Kaneyasu Okawa
发明人： Takami Shibazaki , Kaneyasu Okawa
IPC分类号： G06K9/00
CPC分类号： G01N21/6452 , G01N21/6428 , G01N21/6456
摘要： A fluorescent image is obtained by emitting the light with a wavelength which excites a labelling fluorescent substance, a mask is created by a foreign matter area image extracted from an image of foreign matter adhering to the measurement object obtained by emitting light with a wavelength which does not excite the fluorescent substance, and logical multiplication of the mask and the fluorescent image is executed, thereby obtaining a fluorescent image that a foreign matter area is eliminated from the fluorescent image.
摘要翻译： 通过用激发标记荧光物质的波长发射光而获得荧光图像，通过从附着于测量对象的异物图像提取的异物区域图像产生掩模，该异物区域图像通过发射具有波长的波长而获得的光 不激发荧光物质，并且执行掩模和荧光图像的逻辑倍增，从而获得从荧光图像中除去异物区域的荧光图像。
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公开(公告)号：US08597954B2
公开(公告)日：2013-12-03
申请号：US12944260
申请日：2010-11-11
申请人： Yasuo Tanigami , Kazue Nakajima , Takami Shibazaki
发明人： Yasuo Tanigami , Kazue Nakajima , Takami Shibazaki
IPC分类号： G01N33/48
CPC分类号： C12Q1/6806 , A61B10/0038 , A61B10/0096 , C12N15/1003 , C12N15/1006
摘要： The present invention relates to a stool sample processing method and stool sample processing container the a stool sample processing container provided with a stool collection tool, a suspending solution holding portion and a processing solution holding portion, wherein stool sample preparation solutions consisting of a suspending solution and a stool sample processing solution are respectively housed in a suspending solution holding container and a processing solution holding container, after first mixing a stool sample with the suspending solution and suspending therein, a sealant is released into the suspending solution holding container by pressing on the lower portion of the processing solution holding container, and the resulting stool suspension mixes with the stool sample processing solution that stabilizes the nuclide acid.
摘要翻译： 本发明涉及一种粪便样品处理方法和粪便样品处理容器，该粪便样品处理容器设置有粪便收集工具，悬浮液保持部分和处理溶液保持部分，其中粪便样品制备溶液由悬浮液 和粪便样品处理溶液分别容纳在悬浮液保持容器和处理液保持容器中，首先将粪便样品与悬浮液混合并悬浮在其中后，将密封剂按压在悬浮液保持容器中 处理液保持容器的下部，并且所得到的粪便悬浮液与稳定核素酸的粪便样品处理溶液混合。
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公开(公告)号：US07920733B2
公开(公告)日：2011-04-05
申请号：US11880657
申请日：2007-07-23
申请人： Yuichiro Matsuo , Takami Shibazaki , Yuko Saida
发明人： Yuichiro Matsuo , Takami Shibazaki , Yuko Saida
CPC分类号： G01N21/6456 , G01N21/6452
摘要： First, image capturing is performed in the exposure time of ExpStart. If the maximum intensity value of all the pixels of an image is smaller than TransStart, the exposure time is increased and the image capturing is performed again. After that, increase in the exposure time and the image capturing are repeatedly performed until the maximum intensity value of all the pixels of the captured optical image becomes equal to or greater than TransStart. When the maximum intensity value becomes equal to or greater than TransStart, image data is transferred to a computer to be recorded on the hard disk, and the number of images recorded is counted. Subsequently, the increase in the exposure time, the image capturing, transfer and record of the image data, and count of the number of images recorded are repeatedly performed. The image capturing is finished when the minimum intensity value in an area of the fluorescent image that is smaller than the entire area becomes larger than TransEnd, the number of images recorded becomes larger than TransPicts, or the exposure time becomes longer than MaxExpTime.
摘要翻译： 首先，在ExpStart的曝光时间内执行图像捕获。 如果图像的所有像素的最大强度值小于TransStart，则曝光时间增加，再次执行图像拍摄。 之后，重复执行曝光时间和图像拍摄的增加，直到拍摄的光学图像的所有像素的最大强度值变为等于或大于TransStart。 当最大强度值变得等于或大于TransStart时，将图像数据传送到计算机以记录在硬盘上，并记录所记录的图像数。 随后，重复执行曝光时间的增加，图像捕获，图像数据的传送和记录以及记录的图像数量的计数。 当荧光图像的小于整个区域的区域中的最小强度值变得大于TransEnd时，完成图像捕获，记录的图像数量变得大于TransPicts，或者曝光时间变得比MaxExpTime长。
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9.发明申请公开(公告)号：US20060275893A1
公开(公告)日：2006-12-07
申请号：US11442734
申请日：2006-05-26
CPC分类号： G01N21/75
摘要： A biorelated substance examination apparatus includes a reaction stage which supports a reaction vessel which contains the solid support and promotes a reaction of the solid-state phase, and a microscope which optically observes the solid support. The reaction stage includes a fluid transfer mechanism which transfers a fluid with respect to the reaction vessel and a temperature adjusting mechanism which adjusts a temperature of the solid support in the reaction vessel.
摘要翻译： 生物矫正物质检查装置包括反应阶段，该反应阶段支持包含固体支持物并促进固相的反应的反应容器，以及光学观察固体支持物的显微镜。 反应阶段包括相对于反应容器转移流体的流体转移机构和调节反应容器中的固体支持物的温度的温度调节机构。
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10.发明授权公开(公告)号：US07868279B2
公开(公告)日：2011-01-11
申请号：US12328243
申请日：2008-12-04
申请人： Takami Shibazaki
发明人： Takami Shibazaki
IPC分类号： G02B7/04
CPC分类号： G02B21/245
摘要： The focus detecting apparatus comprises an objective lens, a point light source which irradiates illumination light for generating a focusing signal to a transparent substrate through the objective lens, a mask means having a first shading part for shading one of areas of the luminous of the illumination light, and a photodetector having two light receiving parts, wherein the mask means is formed so as to have a shape similar to one of light receiving parts in the photodetector, and has a second shading part that intercepts a part of luminous flux passing through another area so that reflected light from one of the surfaces may enter into the two light receiving parts, and reflected light from another surface may pass through an area which is located off the light receiving part arranged at one of the areas, when a focus of the objective lens is positioned near one of surfaces out of the first or second surface in the transparent substrate.
摘要翻译： 焦点检测装置包括物镜，点光源，其通过物镜照射用于产生聚焦信号到透明基板的照明光;掩模装置，具有第一遮光部分，用于遮蔽照明的发光的区域之一 光和具有两个光接收部分的光电检测器，其中所述掩模装置形成为具有与所述光电检测器中的光接收部分中的一个相似的形状，并且具有遮断部分通过另一个的光通量的第二遮光部 使得来自其中一个表面的反射光可以进入两个光接收部分，并且来自另一表面的反射光可以穿过布置在其中一个区域处的光接收部分上的区域， 物镜位于透明基板中的第一或第二表面之外的一个表面附近。
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