摘要:
Disclosed are a process for preparation of an optically active 7-substituted 3-(2-aminopropyl)indole compound and an intermediate therefor. In the above preparation process, 7-substituted indole is reacted with L- or DL-serine in the presence of a tryptophan-synthesizing enzyme originating in microorganisms to form corresponding 7-substituted L-tryptophan, and it is subjected, if necessary, to reduction, protection, exchange and elimination.
摘要:
The present invention provides a solid preparation comprising a crystal of [3-[(2R)-[[(2R)-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1H-indol-7-yloxy]acetic acid (Compound A), especially a crystal of Compound A having a particle size of not larger than 100 &mgr;m at the cumulative weight distribution value of 50%, and not larger than 200 &mgr;m at the cumulative weight distribution value of 95%, preferably a solid preparation having the excellent stability and the content uniformity of Compound A, which is prepared by preparing granules of the crystal of Compound A with fillers, disintegrants and binders, and then followed by mixing said granules with external excipients.
摘要:
Disclosed is a compound having a strong affinity to serotonin-4 receptors, which is useful as an enterokinesis-promoting agent or a digestive tract function-improving agent. Specifically, disclosed is a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof. Also specifically disclosed is a pharmaceutical composition containing a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof. [In Formula (1), Ar represents a group represented by Formula (Ar-1) or Formula (Ar-2).]
摘要:
An indole derivative of the formula: ##STR1## wherein R.sub.1 is lower alkoxy, lower alkoxycarbonyl-lower alkoxy, carboxy-lower alkoxy, lower alkoxycarbonyl, phenyl-lower alkoxy, lower alkyl being optionally substituted by hydroxy, di-lower alkylaminosulfonyl, etc., R.sub.2 is hydrogen, halogen, lower alkoxy, lower alkoxycarbonyl-lower alkoxy, carboxy-lower alkoxy, etc., R.sub.3 is hydrogen or lower alkyl, R.sub.4 is halogen or trifluoromethyl, R.sub.5 is lower alkyl, or a salt thereof, these compounds being potent .beta..sub.3 -adrenergic receptor-stimulating agent with excellent adrenoceptor selectivity, and being useful in the prophylaxis or treatment of obesity or diabetes mellitus.
摘要:
Disclosed is a compound having a strong affinity to serotonin-4 receptors, which is useful as an enterokinesis-promoting agent or a digestive tract function-improving agent. Specifically, disclosed is a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof. Also specifically disclosed is a pharmaceutical composition containing a compound represented by Formula (1) or a pharmaceutically acceptable salt thereof. [In Formula (1), Ar represents a group represented by Formula (Ar-1) or Formula (Ar-2).]
摘要:
Compound of the formula (I): wherein Ar is a group of the following formula (Ar-1) or (Ar-2): A is a group of the formula: —Z—N(Q1)(Q2), —CO—R7 or —(CH2)p—CH(R8)—COR9, or a pharmaceutically acceptable acid addition salt thereof, a process for preparing the same, a pharmaceutical composition containing the same, and intermediates therefor. The compounds of the present invention show a potent affinity for 5-HT4 receptors, and they are useful as a gastrointestinal motility enhancer or a gastrointestinal prokinetic agent.
摘要:
This invention discloses a compound which is expressed by formula (I) below: ##STR1## or physiologically acceptable acid addition salts thereof. The claimed compound exhibits excellent antiemetic effect based on its potent serotonin S.sub.3 and dopamine D.sub.2 receptor antagonistic activities, and is useful for treatment or prophylaxis of various gastrointestinal symptoms which are associated with various diseases and drug administration.
摘要:
The invention provides a non-aqueous secondary battery having positive and negative electrodes and non-aqueous electrolyte containing lithium salt which has an energy capacity of 30 Wh or more, a volume energy density of 180 Wh/l or higher, which battery has a flat shape and is superior in heat radiation characteristic, used safely and particularly preferably used for a energy storage system. The invention also provides a control method of the secondary battery.
摘要:
The invention provides a non-aqueous secondary battery having positive and negative electrodes and non-aqueous electrolyte containing lithium salt which has an energy capacity of 30 Wh or more, a volume energy density of 180 Wh/l or higher, which battery has a flat shape and is superior in heat radiation characteristic, used safely and particularly preferably used for a energy storage system. The invention also provides a control method of the secondary battery.
摘要:
The invention provides a non-aqueous secondary battery having positive and negative electrodes and non-aqueous electrolyte containing lithium salt which has an energy capacity of 30 Wh or more, a volume energy density of 180 Wh/l or higher, which battery has a flat shape and is superior in heat radiation characteristic, used safely and particularly preferably used for a energy storage system. The invention also provides a control method of the secondary battery.