公开(公告)号：US20060289309A1

公开(公告)日：2006-12-28

申请号：US11513680

申请日：2006-08-30

申请人： Takashi Fukuzawa ,  Jun Yamaguchi ,  Kenji Uchiyama ,  Akihiko Hattori

发明人： Takashi Fukuzawa ,  Jun Yamaguchi ,  Kenji Uchiyama ,  Akihiko Hattori

IPC分类号： C07K1/26

CPC分类号： F16K99/0017 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/00936 ,  B01L3/502738 ,  B01L2300/161 ,  B01L2400/0672 ,  B01L2400/0688 ,  F16K99/0001 ,  F16K99/0019 ,  F16K99/0036 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0084

摘要： A microchemical system is disclosed that is capable of controlling the flow of a sample solution flowing through a channel in a microchip. In the microchemical system 1, a microchip 7 has therein a T-shaped channel 4 comprised of a main channel 2, a sub-channel 3, and a merging portion 4 where the main channel 2 and the sub-channel 3 merge together. Panel heaters 8 and 9 are installed in a position such as to be able to heat the interior of the sub-channel 3. The sub-channel 3 and the merging portion are subjected to hydrophobic modification treatment. Water is supplied into the main channel 2, and air is supplied into the sub-channel 3.

摘要翻译： 公开了一种微化学系统，其能够控制流过微芯片中的通道的样品溶液的流动。 在微化学系统1中，微芯片7具有由主通道2，子通道3和合流部分4组成的T形通道4，主通道2和子通道3合并在一起。 面板加热器8和9安装在能够加热子通道3的内部的位置。 对子通道3和合流部进行疏水改性处理。 水被供应到主通道2中，并且空气被供应到子通道3中。

公开(公告)号：US20080124247A1

公开(公告)日：2008-05-29

申请号：US11983917

申请日：2007-11-13

申请人： Yoshinori Matsuoka ,  Jun Yamaguchi ,  Takashi Fukuzawa ,  Akihiko Hattori ,  Takehiko Kitamori

发明人： Yoshinori Matsuoka ,  Jun Yamaguchi ,  Takashi Fukuzawa ,  Akihiko Hattori ,  Takehiko Kitamori

IPC分类号： G01N21/64 ,  G01N21/00

CPC分类号： G01N21/0303 ,  B01L3/5027 ,  G01N21/171 ,  G01N21/645

摘要： There are provided a chip for micro chemical systems which can obviate the need of alignment at every measurement and can improve the measurement sensitivity and reduce the variation of measurement, and a micro chemical system using the chip. A thermal lens spectrometry system 10 comprises: a micro chemical chip 2 having a groove 1 into which a sample solution is injected; a rod lens 3 disposed on the micro chemical chip 2 at a predetermined spacing above the groove 1; a lens holder 9 disposed above the micro chemical chip 2; a securing section 4; an optical fiber 5; a ferrule 6 secured by the securing section 4 above the rod lens 3; a light source unit 7 connected to the optical fiber 5, and a detection device 8 disposed below the micro chemical chip 2. The securing section 4 comprises a seating 32 laid on the micro chemical chip 2, and a metal split sleeve 33 for fitting the ferrule 6 and the lens holder 9 at the outside thereof.

摘要翻译： 提供了一种用于微量化学系统的芯片，可以消除每次测量时对准的需要，并且可以提高测量灵敏度并减少测量的变化，以及使用该芯片的微型化学系统。 热透镜分光系统10包括：微化学芯片2，其具有注入样品溶液的槽1; 棒状透镜3，以规定的间隔配置在微细化学品片2上， 设置在微化学芯片2上方的透镜架9; 固定部分4; 光纤5; 由杆状透镜3上方的固定部4固定的套圈6; 连接到光纤5的光源单元7和设置在微化学芯片2下方的检测装置8。 固定部分4包括放置在微化学芯片2上的座32和用于将套圈6和透镜保持器9装配在其外侧的金属分开套筒33。

公开(公告)号：US07304734B2

公开(公告)日：2007-12-04

申请号：US11329456

申请日：2006-01-09

申请人： Takashi Fukuzawa ,  Jun Yamaguchi ,  Akihiko Hattori ,  Takao Miwa

发明人： Takashi Fukuzawa ,  Jun Yamaguchi ,  Akihiko Hattori ,  Takao Miwa

IPC分类号： G01J3/30

CPC分类号： G01N21/645 ,  G01N2021/6482 ,  G01N2021/6484

摘要： A fluorescence analysis optical multiplexer/demultiplexer, a fluorescence analysis optical module, a fluorescence analyzer, a fluorescence/photothermal conversion spectroscopic analyzer, and a fluorescence analysis chip, according to which LIF analysis can be carried out easily and with high sensitivity, and moreover photothermal conversion spectroscopic analysis can be carried out easily and simultaneously with the LIF analysis. A microchemical system 100 as the fluorescence analyzer is comprised of a fluorescence analysis optical module 100a, a probe 50 that condenses exciting light onto a sample solution in a channel 204 inside a fluorescence analysis chip 20, and a sample stage 21 on which the fluorescence analysis chip 20 is mounted. The fluorescence analysis optical module 100a is comprised of an exciting light source 53 that outputs exciting light of dominant wavelength λ1, a fluorescence analysis optical multiplexer/demultiplexer 56 for use in the fluorescence analyzer which analyzes fluorescence of dominant wavelength λ2 (λ2>λ1) emitted from the sample upon the sample being irradiated with the exciting light via the probe 50, a detector 54 that receives the fluorescence, an optical fiber 106 that connects the fluorescence analysis optical multiplexer/demultiplexer 56 to the exciting light source 53, an optical fiber 107 that connects the fluorescence analysis optical multiplexer/demultiplexer 56 to the probe 50, and an optical fiber 108 that connects the fluorescence analysis optical multiplexer/demultiplexer 56 to the detector 54. The channel 204 through which the sample solution is passed is coated with a reflective metal film 205.

公开(公告)号：US20060109465A1

公开(公告)日：2006-05-25

申请号：US11329456

申请日：2006-01-09

申请人： Takashi Fukuzawa ,  Jun Yamaguchi ,  Akihiko Hattori ,  Takao Miwa

发明人： Takashi Fukuzawa ,  Jun Yamaguchi ,  Akihiko Hattori ,  Takao Miwa

IPC分类号： G01N21/64

CPC分类号： G01N21/645 ,  G01N2021/6482 ,  G01N2021/6484

摘要： A fluorescence analysis optical multiplexer/demultiplexer, a fluorescence analysis optical module, a fluorescence analyzer, a fluorescence/photothermal conversion spectroscopic analyzer, and a fluorescence analysis chip, according to which LIF analysis can be carried out easily and with high sensitivity, and moreover photothermal conversion spectroscopic analysis can be carried out easily and simultaneously with the LIF analysis. A microchemical system 100 as the fluorescence analyzer is comprised of a fluorescence analysis optical module 100a, a probe 50 that condenses exciting light onto a sample solution in a channel 204 inside a fluorescence analysis chip 20, and a sample stage 21 on which the fluorescence analysis chip 20 is mounted. The fluorescence analysis optical module 100a is comprised of an exciting light source 53 that outputs exciting light of dominant wavelength λ1, a fluorescence analysis optical multiplexer/demultiplexer 56 for use in the fluorescence analyzer which analyzes fluorescence of dominant wavelength λ2 (λ2>λ1) emitted from the sample upon the sample being irradiated with the exciting light via the probe 50, a detector 54 that receives the fluorescence, an optical fiber 106 that connects the fluorescence analysis optical multiplexer/demultiplexer 56 to the exciting light source 53, an optical fiber 107 that connects the fluorescence analysis optical multiplexer/demultiplexer 56 to the probe 50, and an optical fiber 108 that connects the fluorescence analysis optical multiplexer/demultiplexer 56 to the detector 54. The channel 204 through which the sample solution is passed is coated with a reflective metal film 205.

公开(公告)号：US08063384B2

公开(公告)日：2011-11-22

申请号：US12438536

申请日：2007-11-20

申请人： Takashi Fukuzawa ,  Jun Yamaguchi

发明人： Takashi Fukuzawa ,  Jun Yamaguchi

IPC分类号： G01J1/58

CPC分类号： G01N21/645 ,  G01N2021/6463 ,  G01N2021/6484

摘要： There is provided a detection system capable of simultaneously detecting a plurality of fluorescences or phosphorescences having different dominant wavelengths generated from a minute region and a probe therefor. A fluorescence detection system includes a probe having a lens and optical fibers and arranged on one end thereof. The probe receives excitation light with a dominant wavelength and excitation light with a dominant wavelength at one end of the lens and converges the excitation lights at the solution containing Cy3 and Cy5 in a channel inside a microchemical chip and the probe receives fluorescence with a dominant wavelength and fluorescence with a dominant wavelength at the other end of the lens and converges the fluorescences at the tips of the optical fibers.

摘要翻译： 提供了能够同时检测由微小区域产生的具有不同主要波长的多个荧光或磷光的检测系统及其探针。 荧光检测系统包括具有透镜和光纤并且布置在其一端的探针。 探头接收具有主波长的激发光和在透镜一端具有主波长的激发光，并将激发光在含有Cy3和Cy5的溶液中收敛在微化学芯片内的通道内，并且探针接收具有主波长的荧光 和在透镜另一端具有主波长的荧光，并将荧光收敛在光纤的尖端处。

公开(公告)号：US20050259259A1

公开(公告)日：2005-11-24

申请号：US11132892

申请日：2005-05-18

申请人： Jun Yamaguchi ,  Takashi Fukuzawa

发明人： Jun Yamaguchi ,  Takashi Fukuzawa

IPC分类号： G01N25/16 ,  G01N21/17 ,  G01N21/41 ,  G01N21/61 ,  G01N37/00

CPC分类号： G01N21/171 ,  G01N2021/1712

摘要： A photothermal conversion spectroscopic analysis method which is capable of performing analysis, measurement and detection with high sensitivity. A sample flows in a channel. A exciting light and a detecting light are exited. A gradient refractive index rod lens converges the exited light and forms a focal point at a position in or close to the channel. Intensity of the exited light and passing through the channel are detected. A depth of the channel is not less than two time as large as a difference in distance between focal positions of the exciting light and the detecting light.

摘要翻译： 一种能够以高灵敏度进行分析，测量和检测的光热转换光谱分析方法。 样品在通道中流动。 激发光和探测光退出。 梯度折射率棒状透镜会聚退出的光，并且在通道中或靠近通道的位置处形成焦点。 检测到退出的光并通过通道的强度。 通道的深度不小于激发光的焦点位置与检测光之间的距离差的两倍。

公开(公告)号：US20080030718A1

公开(公告)日：2008-02-07

申请号：US11881641

申请日：2007-07-26

申请人： Shinji Tamai ,  Takashi Fukuzawa ,  Jun Yamaguchi

发明人： Shinji Tamai ,  Takashi Fukuzawa ,  Jun Yamaguchi

IPC分类号： G01N21/00 ,  G06F15/00

CPC分类号： G01N21/6452 ,  G01N21/171 ,  G01N25/4813 ,  G01N2021/1714

摘要： A detection method that can measure a plurality of measured substances in a fluid test sample at the same time, easily perform qualitative analysis and quantitative analysis, and reduce measurement errors between excitation energies of the measured substances, and a microchemical system using the detection method. A probe light with a wavelength of 780 nm CW-oscillated from a probe light source 16 is irradiated on measured substances in a minute channel 1, excitation lights with wavelengths of 658 nm and 532 nm, respectively, are modulated into plurality of flashing excitation lights with frequencies 1 kHz and 1.2 kHz and a duty factor of 50% and irradiated on the measured substances in the minute channel 1, the probe light refracted by a thermal lens formed by the irradiated flashing excitation lights is detected with respect to individual frequency components at the same time, and a signal of the detected probe light is guided from a PD 21 to a PC 24 as a signal processing apparatus via an IV amplifier 22. The PC 24 carries out FFT processing to measure the intensity of the signal with respect to individual frequency components.

摘要翻译： 可以同时测量流体试样中的多种测定物质的检测方法，容易进行定性分析和定量分析，并减少被测物质的激发能量之间的测量误差，以及使用该检测方法的微化学系统。 将从探测光源16振荡的波长为780nm的探测光照射在分钟通道1中的测量物质上，分别将波长为658nm和532nm的激发光调制到多个闪光激发光 以1kHz和1.2kHz的频率和50％的占空因数照射在微通道1中的测量物质上，通过由照射的闪光激发光形成的热透镜折射的探测光相对于各个频率分量被检测 同时，检测到的探测光的信号经由IV放大器22作为信号处理装置从PD 21引导到PC24。 PC24进行FFT处理，以测量相对于各个频率分量的信号的强度。

公开(公告)号：US20100224793A1

公开(公告)日：2010-09-09

申请号：US12438536

申请日：2007-11-20

申请人： Takashi Fukuzawa ,  Jun Yamaguchi

发明人： Takashi Fukuzawa ,  Jun Yamaguchi

IPC分类号： G01N21/64 ,  G02B6/32

CPC分类号： G01N21/645 ,  G01N2021/6463 ,  G01N2021/6484

摘要： There is provided a detection system capable of simultaneously detecting a plurality of fluorescences or phosphorescences having different dominant wavelengths generated from a minute region and a probe therefor. A fluorescence detection system includes a probe having a lens and optical fibers and arranged on one end thereof. The probe receives excitation light with a dominant wavelength and excitation light with a dominant wavelength at one end of the lens and converges the excitation lights at the solution containing Cy3 and Cy5 in a channel inside a microchemical chip and the probe receives fluorescence with a dominant wavelength and fluorescence with a dominant wavelength at the other end of the lens and converges the fluorescences at the tips of the optical fibers.

摘要翻译： 提供了能够同时检测由微小区域产生的具有不同主要波长的多个荧光或磷光的检测系统及其探针。 荧光检测系统包括具有透镜和光纤并且布置在其一端的探针。 探头接收具有主波长的激发光和在透镜一端具有主波长的激发光，并将激发光在含有Cy3和Cy5的溶液中收敛在微化学芯片内的通道内，并且探针接收具有主波长的荧光 和在透镜另一端具有主波长的荧光，并将荧光收敛在光纤的尖端处。

公开(公告)号：US06943954B2

公开(公告)日：2005-09-13

申请号：US09964735

申请日：2001-09-28

申请人： Shuya Ogi ,  Takashi Fukuzawa ,  Koichiro Iki ,  Masahide Wakisaka ,  Kiyotaka Sasaki

发明人： Shuya Ogi ,  Takashi Fukuzawa ,  Koichiro Iki ,  Masahide Wakisaka ,  Kiyotaka Sasaki

IPC分类号： G02B3/00 ,  G02B27/10

CPC分类号： G02B3/0056 ,  G02B3/0012 ,  G02B3/005 ,  G02B3/0087

摘要： An aligning tool having a plurality of grooves formed side by side is provided; gradient index rod lenses are placed in alignment within the grooves at an average spacing of 1 μm-5 μm; the gradient index rod lenses are fixed to form an integral unit as they maintain the aligned state; thereafter the end faces of each rod lens are polished.

摘要翻译： 提供具有并排形成的多个槽的对准工具; 梯度折射率棒状透镜以平均间距为1mum-5mum放置在凹槽内对准; 梯度分度杆透镜在保持对准状态时被固定以形成整体单元; 此后，每个棒状透镜的端面被抛光。

公开(公告)号：US07194160B2

公开(公告)日：2007-03-20

申请号：US10366998

申请日：2003-02-14

申请人： Hiroyuki Tanaka ,  Akimitsu Sato ,  Takeshi Ishimaru ,  Takashi Fukuzawa

发明人： Hiroyuki Tanaka ,  Akimitsu Sato ,  Takeshi Ishimaru ,  Takashi Fukuzawa

IPC分类号： G02B6/32 ,  G02B6/26 ,  G02B6/42

CPC分类号： G02B6/2938 ,  G02B6/2937 ,  G02B6/3845

摘要： A filter module includes a first optical fiber collimator, a second optical fiber collimator, and a filter located between the first and second optical fiber collimators. The first optical fiber collimator includes a first optical fiber, a first optical fiber chip for holding the first optical fiber, and a first lens. The second optical fiber collimator includes second optical fibers, a second optical fiber chip for holding the second optical fiber, and a second lens. The filter is located between and coaxial with the first and second lenses. The filter, the first lens, and the second lens form a center piece of the filter module.

摘要翻译： 滤波器模块包括第一光纤准直器，第二光纤准直器和位于第一和第二光纤准直器之间的滤光器。 第一光纤准直器包括第一光纤，用于保持第一光纤的第一光纤芯片和第一透镜。 第二光纤准直器包括第二光纤，用于保持第二光纤的第二光纤芯片和第二透镜。 过滤器位于第一和第二透镜之间并且与第一和第二透镜同轴。 过滤器，第一透镜和第二透镜形成过滤器模块的中心件。