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公开(公告)号:US3959252A
公开(公告)日:1976-05-25
申请号:US282013
申请日:1972-08-21
IPC分类号: C07H17/08 , C07C129/18
CPC分类号: C07H17/08
摘要: Alkanoyl-josamycins having no bitter taste, in which at least one of the two secondary hydroxyl groups of Josamycin is acylated (introduction of alkanoyl group). The compounds have the same pharmaceutical effect as Josamycin which is effective in inhibiting the growth of Gram-positive bacteria.
摘要翻译: 没有苦味的烷酰基 - 吉萨米星,其中至少一个Josamycin的两个仲羟基被酰化(引入烷酰基)。 该化合物具有与抑制革兰氏阳性菌生长有效的约霉素相同的药效。
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公开(公告)号:US4001399A
公开(公告)日:1977-01-04
申请号:US580345
申请日:1975-05-23
CPC分类号: C07H17/08
摘要: Alkanoyl-josamycins having no bitter taste, in which at least one of the two secondary hydroxyl groups of Josamycin is acylated (introduction of alkanoyl group).
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公开(公告)号:US4279997A
公开(公告)日:1981-07-21
申请号:US72654
申请日:1979-09-05
申请人: Yoshihiko Oka , Hitoshi Ishida , Moto Morioka , Yoso Numusaki , Tsutomu Yamafuji , Takashi Osono , Hamao Umezawa
发明人: Yoshihiko Oka , Hitoshi Ishida , Moto Morioka , Yoso Numusaki , Tsutomu Yamafuji , Takashi Osono , Hamao Umezawa
IPC分类号: A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/236 , C12P19/48 , C12P19/50 , C12R1/29
CPC分类号: C07H15/236 , C12P19/485 , Y10S435/867
摘要: Aminoglycoside antibiotics biochemically transformed from Kanamycin A or Kanamycin B, which are represented by the formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group and R.sub.2 represents an amino group or a hydroxyl group.
摘要翻译: 由卡那霉素A或卡那霉素B生物化学转化的氨基糖苷类抗生素,其由式表示,其中R1表示氢原子或甲基,R2表示氨基或羟基。
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公开(公告)号:US4209511A
公开(公告)日:1980-06-24
申请号:US793
申请日:1979-01-03
申请人: Yoshihiko Oka , Hitoshi Ishida , Moto Morioka , Yoso Numasaki , Tsutomu Yamafuji , Takashi Osono , Hamao Umezawa
发明人: Yoshihiko Oka , Hitoshi Ishida , Moto Morioka , Yoso Numasaki , Tsutomu Yamafuji , Takashi Osono , Hamao Umezawa
IPC分类号: A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/236 , C12P19/48 , C12P19/50 , C12R1/29 , A61K31/71 , C07H15/22
CPC分类号: C07H15/236 , C12P19/485 , Y10S435/867
摘要: Aminoglycoside antibiotics biochemically transformed from Kanamycin A or Kanamycin B, which are represented by the formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group and R.sub.2 represents an amino group or a hydroxyl group.
摘要翻译: 由卡那霉素A或卡那霉素B生物化学转化的氨基糖苷类抗生素,其由式表示,其中R1表示氢原子或甲基,R2表示氨基或羟基。
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公开(公告)号:US4242449A
公开(公告)日:1980-12-30
申请号:US879786
申请日:1978-02-21
申请人: Takashi Osono , Yoshihiko Oka , Shunichi Watanabe , Takeshi Saito , Hiroshi Gushima , Keisuke Murakami , Isao Takahashi , Hiroshi Yamaguchi , Toshio Sasaki , Kiyoshi Susaki , Shuichi Takamura , Toshiaki Miyoshi
发明人: Takashi Osono , Yoshihiko Oka , Shunichi Watanabe , Takeshi Saito , Hiroshi Gushima , Keisuke Murakami , Isao Takahashi , Hiroshi Yamaguchi , Toshio Sasaki , Kiyoshi Susaki , Shuichi Takamura , Toshiaki Miyoshi
IPC分类号: C12P35/08
CPC分类号: C12P35/08 , Y10S435/803 , Y10S435/886 , Y10S435/911
摘要: The 7-methoxy-3-heterocyclic thiomethyl cephalosporin derivative possessing excellent antimicrobial activity represented by the general formula ##STR1## wherein R.sup.1 represents ##STR2## group or HOOC-- group, R.sup.2 represents a nitrogen-containing heterocyclic group, and M represents a hydrogen atom or a cation residue forming a salt.
摘要翻译: 具有由通式
表示的优异的抗微生物活性的7-甲氧基-3-杂环硫代甲基头孢菌素衍生物,其中R1表示<或者HOOC-基团,R2表示含氮杂环基,M表示氢原子 或形成盐的阳离子残留物。 -
公开(公告)号:US4039660A
公开(公告)日:1977-08-02
申请号:US613738
申请日:1975-09-16
申请人: Takashi Osono , Shunichi Watanabe , Takeshi Saito , Hiroshi Gushima , Keisuke Murakami , Isao Takahashi , Hiroshi Yamaguchi , Toshio Sasaki , Yoshihiko Oka
发明人: Takashi Osono , Shunichi Watanabe , Takeshi Saito , Hiroshi Gushima , Keisuke Murakami , Isao Takahashi , Hiroshi Yamaguchi , Toshio Sasaki , Yoshihiko Oka
IPC分类号: C07D501/57 , A61K31/545 , A61K31/546 , A61P31/04 , C12P35/08 , A61K35/74
CPC分类号: A61K31/545 , C12P35/08 , Y10S435/886
摘要: A new antibiotic substance, designated Y-G19ZD3, is produced by the fermentation of a newly discovered microorganism Streptomyces organonensis Y-G19Z or a mutant thereof. The antibiotic substance Y-G19ZD3 is effective against gram negative bacteria and is useful also as an intermediate for the production of other antibiotics.
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公开(公告)号:US4656262A
公开(公告)日:1987-04-07
申请号:US808680
申请日:1985-12-13
申请人: Takashi Osono , Yoshihiko Oka , Shunichi Watanabe , Takeshi Saito , Hiroshi Gushima , Keisuke Murakami , Isao Takahashi , Hiroshi Yamaguchi , Toshio Sasaki , Kiyoshi Susaki , Shuichi Takamura , Toshiaki Miyoshi
发明人: Takashi Osono , Yoshihiko Oka , Shunichi Watanabe , Takeshi Saito , Hiroshi Gushima , Keisuke Murakami , Isao Takahashi , Hiroshi Yamaguchi , Toshio Sasaki , Kiyoshi Susaki , Shuichi Takamura , Toshiaki Miyoshi
IPC分类号: C07D501/57 , C12P35/08 , C07D501/28 , A61K31/545
摘要: The 7-methoxy-3-heterocyclic thiomethyl cephalosporin derivative possessing excellent antimicrobial activity represented by the general formula ##STR1## wherein R.sup.1 represents ##STR2## group or HOOC-- group, R.sup.2 represents a nitrogen-containing heterocyclic group, and M represents a hydrogen atom or a cation residue forming a salt.
摘要翻译: 具有由通式
表示的优异的抗微生物活性的7-甲氧基-3-杂环硫代甲基头孢菌素衍生物,其中R1表示<或者HOOC-基团,R2表示含氮杂环基,M表示氢原子 或形成盐的阳离子残留物。 -
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公开(公告)号:US4410626A
公开(公告)日:1983-10-18
申请号:US201739
申请日:1980-10-29
申请人: Hiroshi Gushima , Shunichi Watanabe , Takeshi Saito , Toshio Sasaki , Hideo Eiki , Yoshihiko Oka , Takashi Osono
发明人: Hiroshi Gushima , Shunichi Watanabe , Takeshi Saito , Toshio Sasaki , Hideo Eiki , Yoshihiko Oka , Takashi Osono
IPC分类号: A61K31/545 , A61K31/546 , A61P31/04 , C07D501/57 , C12P35/08 , C12N9/06 , C12R1/465 , C12R1/52
CPC分类号: C12P35/08 , Y10S435/886 , Y10S435/893 , Y10S435/897
摘要: 7.alpha.-Methoxy-3-p-sulfooxy or p-hydroxycinnamoyloxymethyl cephalosporin derivatives which are useful as antibiotics and as intermediates for the production of other 7.alpha.-methoxycephalosporin derivatives.
摘要翻译: 7α-甲氧基-3-对磺基氧基或对羟基肉桂酸氧甲基头孢菌素衍生物,其可用作抗生素和用作生产其它7种α-甲氧基头孢菌素衍生物的中间体。
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公开(公告)号:US4259326A
公开(公告)日:1981-03-31
申请号:US097823
申请日:1979-11-27
申请人: Hiroshi Gushima , Shunichi Watanabe , Takeshi Saito , Toshio Sasaki , Hideo Eiki , Yoshihiko Oka , Takashi Osono
发明人: Hiroshi Gushima , Shunichi Watanabe , Takeshi Saito , Toshio Sasaki , Hideo Eiki , Yoshihiko Oka , Takashi Osono
IPC分类号: A61K31/545 , A61K31/546 , A61P31/04 , C07D501/57 , C12P35/08 , C07D501/20
CPC分类号: C12P35/08 , Y10S435/886 , Y10S435/893 , Y10S435/897
摘要: 7.alpha.-Methoxy-3-p-sulfooxy or p-hydroxycinnamoyloxymethyl cephalosporin derivatives which are useful as antibiotics and as intermediates for the production of other 7.alpha.-methoxycephalosporin derivatives.
摘要翻译: 7α-甲氧基-3-对磺基氧基或对羟基肉桂酸氧甲基头孢菌素衍生物,其可用作抗生素和用作生产其它7种α-甲氧基头孢菌素衍生物的中间体。
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