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    Process for producing a particulate composition comprising anhydrous crystalline 2-O-alpha-D-glucosyl-L-ascorbic acid
    2.
    发明授权
    Process for producing a particulate composition comprising anhydrous crystalline 2-O-alpha-D-glucosyl-L-ascorbic acid 有权
    制备包含无水结晶的2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物的方法

    公开(公告)号：US09265781B2

    公开(公告)日：2016-02-23

    申请号：US13980223

    申请日：2012-03-07

    申请人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

    发明人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

    IPC分类号： C12P19/18 ,  A61K31/7048 ,  C07H17/04 ,  C12P19/60 ,  A61K9/16

    CPC分类号： A61K31/7048 ,  A61K9/16 ,  C07H17/04 ,  C12P19/18 ,  C12P19/60 ,  C12Y204/01019

    摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.

    摘要翻译： 本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。 制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得 将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高到86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过 控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。

    Refined royal jelly
    3.
    发明申请
    Refined royal jelly 审中-公开
    精制皇家果冻

    公开(公告)号：US20060159834A1

    公开(公告)日：2006-07-20

    申请号：US10525157

    申请日：2003-09-04

    申请人： Takashi Shibuya ,  Shigeharu Fukuda ,  Toshio Miyake

    发明人： Takashi Shibuya ,  Shigeharu Fukuda ,  Toshio Miyake

    IPC分类号： A23K1/00

    CPC分类号： A61K8/64 ,  A23G9/38 ,  A23K20/10 ,  A23K50/40 ,  A23L21/20 ,  A23L33/11 ,  A23L33/15 ,  A23V2002/00 ,  A61K8/988 ,  A61Q19/00 ,  A23V2200/304

    摘要： The object of the present invention is to provide an allergen-reduced royal jelly, having less fear of causing allergic symptoms, obtained by reducing allergens and keeping the useful pharmacological actions of royal jelly, a process for producing the same, and its uses. The present invention solves the above object by providing an allergen-reduced royal jelly where the amount of water-soluble proteins is reduced to less than 50% (w/w) to the amount of total proteins; a process for producing the allergen-reduced royal jelly comprising the steps of separating a royal jelly into a precipitate and a supernatant comprising water-soluble proteins by adding water and centrifuging, collecting low molecular substances by eliminating high molecular substances comprising water-soluble proteins from the resulting supernatant using ultra-filtration or gel filtration chromatography, and mixing the resulting low molecular substances with the aforesaid precipitate; a composition comprising the allergen-reduced royal jelly; and the uses of the composition for foods, feeds, baits, pet foods, and cosmetics.

    摘要翻译： 本发明的目的是提供一种通过减少过敏原并保持蜂王浆的有用药理作用而获得的对过敏症状的恐惧较少的过敏原降低的蜂王浆，其制备方法及其用途。 本发明通过提供一种致敏剂降低的蜂王浆来解决上述目的，其中水溶性蛋白质的量降低到总蛋白质量的少于50％（w / w）; 一种生产降解过敏原的蜂王浆的方法，包括以下步骤：将蜂王浆分离成沉淀物，通过加入水分和离心分离含有水溶性蛋白质的上清液，通过除去含有水溶性蛋白质的高分子物质来收集低分子物质 所得上清液使用超滤或凝胶过滤层析，并将得到的低分子物质与上述沉淀物混合; 包含变应原降低的蜂王浆的组合物; 以及食品，饲料，饵料，宠物食品和化妆品组合物的用途。

    PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING ANHYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID
    6.
    发明申请
    PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING ANHYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID 有权
    生产包含无水晶体2-O-ALPHA-D-葡萄糖-L-抗坏血酸的颗粒组合物的方法

    公开(公告)号：US20140178943A9

    公开(公告)日：2014-06-26

    申请号：US13980223

    申请日：2012-03-07

    申请人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

    发明人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

    IPC分类号： C12P19/18

    CPC分类号： A61K31/7048 ,  A61K9/16 ,  C07H17/04 ,  C12P19/18 ,  C12P19/60 ,  C12Y204/01019

    摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.

    摘要翻译： 本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。 制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得 将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高至86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过 控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。

    PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING ANHYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID
    7.
    发明申请
    PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING ANHYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID 有权
    生产包含无水晶体2-O-ALPHA-D-葡萄糖-L-抗坏血酸的颗粒组合物的方法

    公开(公告)号：US20130295618A1

    公开(公告)日：2013-11-07

    申请号：US13980223

    申请日：2012-03-07

    申请人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

    发明人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

    IPC分类号： C12P19/18

    CPC分类号： A61K31/7048 ,  A61K9/16 ,  C07H17/04 ,  C12P19/18 ,  C12P19/60 ,  C12Y204/01019

    摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.

    摘要翻译： 本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。 制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得 将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高至86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过 控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。

    PARTICULATE COMPOSITION CONTAINING ANHYDROUS CRYSTALLINE 2-O-alpha-D-GLUCOSYL-L-ASCORBIC ACID, PROCESS FOR PRODUCING THE SAME, AND USES THEREOF
    8.
    发明申请
    PARTICULATE COMPOSITION CONTAINING ANHYDROUS CRYSTALLINE 2-O-alpha-D-GLUCOSYL-L-ASCORBIC ACID, PROCESS FOR PRODUCING THE SAME, AND USES THEREOF 有权
    包含无水晶体2-O-α-D-葡糖醛酸-L-抗坏血酸的颗粒组合物，其生产方法及其用途

    公开(公告)号：US20110091726A1

    公开(公告)日：2011-04-21

    申请号：US12875786

    申请日：2010-09-03

    申请人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

    发明人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

    IPC分类号： B32B5/00 ,  C07H19/01 ,  C12P19/60

    CPC分类号： C12P19/60 ,  A23L33/10 ,  A23L33/15 ,  A61K8/0241 ,  A61K8/676 ,  A61K8/732 ,  A61K31/7048 ,  A61K2800/57 ,  A61K2800/654 ,  A61Q19/02 ,  C07H17/04 ,  Y10T428/2982

    摘要： The present invention aims to provide a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid having a significantly, hardly solidifiable property compared to conventional ones in a grade for use in quasi-drugs; a process for producing the same; and uses thereof. The present invention solves the above object by providing a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic in an amount of over 98.0% by weight but less than 99.9% by weight, on a dry solid basis; or a degree of crystallinity of 90% or higher for anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid, when calculated based on a profile of powder X-ray diffraction analysis of the particulate composition, and a dynamic vapor sorption level of 0.01% by weight or lower, when kept at 25° C. under a relative humidity of 35% by weight for 12 hours after removal water in the particulate composition under nitrogen gas stream; and by providing a process for producing the same and uses thereof.

    摘要翻译： 本发明的目的在于提供一种含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物，其与用于准药物的级别相比，具有显着难以固化的性能; 其制造方法; 及其用途。 本发明通过提供含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物来解决上述目的，其含量超过98.0重量％但小于99.9重量％，基于干固体 ; 或无水结晶2-O-α-D-葡糖基-L-抗坏血酸的结晶度为90％以上时，基于颗粒组合物的粉末X射线衍射分析曲线和动态蒸气 当在氮气流下除去颗粒组合物中的水后，在25℃相对湿度35重量％下保持12小时，吸附水平为0.01重量％以下; 并提供其制造方法及其用途。

    Process for producing 2-O-alpha-D-glucopyranosyl-L-ascorbic acid
    10.
    发明授权
    Process for producing 2-O-alpha-D-glucopyranosyl-L-ascorbic acid 有权
    制备2-O-α-D-吡喃葡萄糖基-L-抗坏血酸的方法

    公开(公告)号：US08759030B2

    公开(公告)日：2014-06-24

    申请号：US10523920

    申请日：2003-07-07

    申请人： Kazuhisa Mukai ,  Keiji Tsusaki ,  Michio Kubota ,  Shigeharu Fukuda ,  Toshio Miyake

    发明人： Kazuhisa Mukai ,  Keiji Tsusaki ,  Michio Kubota ,  Shigeharu Fukuda ,  Toshio Miyake

    IPC分类号： C12P19/44

    CPC分类号： C12P19/60

    摘要： The object of the present invention is to provide a method and a process for producing 2-O-α-glucopyranosyl-L-ascorbic acid where 5-O-α-glucopyranosyl-L-ascorbic acid and 6-O-α-glucopyranosyl-L-ascorbic acid are not formed or formed in such a small amount that the formation of these can nor be detected. The present invention solves the above object by providing a process for producing 2-O-α-glucopyranosyl-L-ascorbic acid comprising the steps of allowing α-isomaltosyl glucosaccharide-forming enzyme together with or without cyclomaltodextrin glucanotransferase (EC 2.4.1.19) to act on a solution comprising L-ascorbic acid and, an α-glucosyl saccharide to form 2-O-α-glucopyranosyl-L-ascorbic acid and collecting the formed 2-O-α-glucopyranosyl-L-ascorbic acid.

    摘要翻译： 本发明的目的是提供一种生产2-O-α-吡喃葡萄糖基-L-抗坏血酸的方法和方法，其中5-O-α-吡喃葡萄糖基-L-抗坏血酸和6-O-α-吡喃葡萄糖基 - L-抗坏血酸不是以这样的少量形成或形成，也可以不形成。 本发明通过提供一种生产2-O-α-吡喃葡萄糖基-L-抗坏血酸的方法来解决上述目的，其包括以下步骤：将α-异麦芽糖基葡萄糖形成酶与或不与环糊精葡聚糖转移酶（EC 2.4.1.19）一起 作用于包含L-抗坏血酸和α-葡萄糖基糖的溶液中以形成2-O-α-吡喃葡萄糖基-L-抗坏血酸并收集形成的2-O-α-吡喃葡萄糖基-L-抗坏血酸。