摘要:
By searching various compounds having an inhibiting activity against IL-12/IL-23 production, the present invention provides a pharmaceutical composition or a therapeutic or preventive agent for diseases related to IL-12/IL-23 excessive production each of which comprises the compound(s) of the present invention.More specifically, the present invention provides an imidazopyridazine compound having an inhibiting activity against IL-12/IL-23 production or pharmaceutically acceptable salts thereof; and a useful pharmaceutical composition or a useful therapeutic or preventive agent for diseases related to IL-12/IL-23 excessive production each of which comprises said compound or pharmaceutically acceptable salts thereof.
摘要:
The present invention has searched for a variety of compounds which show IL-12/IL-23 production-inhibitory activities and herein provides a pharmaceutical composition and an agent for preventing or treating IL-12/IL-23 excess production-related diseases, which comprise the compound.
摘要:
A spindle motor includes a stationary portion and a rotating portion. The stationary portion preferably includes a shaft portion, an upper thrust portion, and an outer tubular portion. The rotating portion preferably includes an inner tubular portion, a flange portion, an upper hub annular portion, and a lower hub annular portion. The flange portion includes a communicating hole. An upper surface of a lubricating oil is located in a fifth gap defined between an upper thrust portion and an upper hub annular portion, while a lower surface of the lubricating oil is located in a sixth gap defined between an outer tubular portion and a lower hub annular portion. The communicating hole and a space extending from the fifth gap to the sixth gap through a fourth gap, a first gap, a second gap, and a third gap are continuously filled with the lubricating oil.
摘要:
A dynamic pressure bearing is defined in a first gap between a shaft portion and a sleeve portion. An upper seal portion extending upward and a lower seal portion extending downward are arranged radially outward of the dynamic pressure bearing. Each of the upper seal portion and the lower seal portion includes a surface including a lubricating oil located therein. The upper seal portion and the lower seal portion are arranged in communication with each other through a communicating hole defined in the sleeve portion. The communicating hole and a space ranging from the upper seal portion to the lower seal portion through the first gap are filled with the lubricating oil. The axial distance between the surfaces of the lubricating oil in the upper seal portion and the lower seal portion is arranged to be shorter than the axial distance between an upper end and a lower end of the dynamic pressure bearing.
摘要:
A soft contact lens (SCL) package product which can be advantageously supplied to hydrated SCL wearers, a method of shipping a SCL shipped in the form of such a SCL package product and a method of packaging the SCL, are provided. A liquid medium 12 containing at least one anionic compound having two or more anionic functional groups in one molecule and at least one cationic compound having two or more cationic functional groups in one molecule is housed in a sealable container 4 together with a hydrated SCL 10. Then, the container 4 is sealed, and the inside of the container 4 is held in a sterile state to obtain a SCL package product 2.
摘要:
In the present invention, a plurality of ultra-small condenser microphones is formed on a same substrate. Then, charges are fixed to a dielectric film provided in each of the ultra-small condenser microphones. After an amount of deposited charges in each of the dielectric films is inspected, the substrate whereon the plurality of ultra-small condenser microphones is formed is diced so that each of the ultra-small condenser microphones is separated. Thus, at least the step of fixing charges is performed in a substrate state where the plurality of ultra-small condenser microphones is formed on the same substrate. Therefore, the present invention contributes to enhancement of productivity in an assembly process of the ultra-small condenser microphone and reduction in equipment costs.
摘要:
A light receptacle comprises: a column-shaped fiber stub; a cylindrical holder made of an insulating material, the holder being in contact with whole circumference of an outer peripheral surface at one end of the fiber stub and holding the fiber stub; a sleeve being in contact with whole circumference of the outer peripheral surface at the other end of the fiber stub; a first metal case being in contact with whole circumference of an outer peripheral surface of a part of the holder and surrounding the part of the holder and the sleeve; and a second metal case being in contact with whole circumference of an outer peripheral surface of a remaining portion of the holder located outside of the first metal case, leaving a space between the first metal case and the second metal case.
摘要:
A plasma processing apparatus and a method of manufacturing a semiconductor device which can prevent a discharge from occurring between a substrate such as a semiconductor wafer or the like, and a base material of a lower electrode or a peripheral structure of the base material, and can improve yield and productivity. The plasma processing apparatus includes a processing chamber, a lower electrode, an upper electrode, and a plurality of lifter pins for supporting a substrate to be processed. Each of the lifter pins includes a pin body part and a lid part which is disposed on a top portion of the pin body part and has an outer diameter greater than an outer diameter of the pin body part. The lower electrode includes through-holes for lifter pins each of which includes a pin body receiving part, which has an inner diameter less than the outer diameter of the lid part and receives the pin body part, and a lid receiving part, which is formed in an upper portion of the pin body receiving part and receives the cover portion, and in which the lifter pins are disposed. In a state where the lifter pins are lowered, the lid part is received in the lid receiving part, and the upper portion of the pin body receiving part is blocked by the lid part.
摘要:
A bicycle chain tensioner is provided with a bracket, a tensioner arm, a securing position adjustment mechanism and a chain engaging member. The bracket has a bicycle axle mounting portion and an arm attachment portion. The tensioner arm is adjustably secured to the arm attachment portion of the bracket. The securing position adjustment mechanism selectively fixes the tensioner arm with respect to the bracket in one of a plurality of the securing positions. The chain engaging member is attached to the tensioner arm.
摘要:
An apparatus for distinguishing a liquid reducing agent which judges empty with a higher precision than heretofore is provided. The apparatus for distinguishing a liquid reducing agent is provided with a concentration sensor and a liquid-level sensor in a storage tank of liquid reducing agent, and is characterized in that empty is judged by utilizing the liquid-level based on the liquid-level sensor in addition to the concentration based on the concentration sensor (step 3 and step 5). Even if a bubble is adhering to the concentration sensor and an erroneous signal indicative of empty is output although the residual quantity of liquid reducing agent is sufficient, the liquid-level sensor does not output a signal indicative of empty. Consequently, erroneous judgment is prevented and accurate judgment can be made as compared to heretofore.