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公开(公告)号:US20210087186A1
公开(公告)日:2021-03-25
申请号:US16961476
申请日:2019-01-30
发明人: Yuta TANAKA , Tomohiro OHASHI , Zenichi IKEDA , Yuta TANAKA , Florian PÜNNER , Takeshi YAMAMOTO , Keiko KAKEGAWA , Fumiaki KIKUCHI , Nao MORISHITA , Takahito KASAHARA , Masaki SETO , Minoru NAKAMURA , Kazuaki TAKAMI , Masataka MURAKAMI , Masaki DAINI , Satoshi MIKAMI , Minoru SASAKI
IPC分类号: C07D471/04 , C07D495/04 , C07D487/04 , C07D491/048 , C07D519/00
摘要: The present invention provides a compound having a glucosylceramide lowering action (e.g., promoting glucosylceramide metabolism, inhibition of glucosylceramide synthesis, promoting glucosylceramide catabolism, etc.), which is expected to be useful as an agent for the prophylaxis or treatment of lysosome diseases (e.g., Gaucher's disease), neurodegenerative diseases (e.g., Parkinson's disease, Lewy body dementia, multiple-system atrophy) and the like.
The present invention relates to a compound represented by the formula (I) wherein each symbol is as described in the specification, or a salt thereof.-
公开(公告)号:US20220289679A1
公开(公告)日:2022-09-15
申请号:US17630442
申请日:2020-07-28
发明人: Yuta TANAKA , Yuta TANAKA , Keiko KAKEGAWA , Takahito KASAHARA , Fumiaki KIKUCHI , Takeshi YAMAMOTO , Tomohiro OHASHI , Zenichi IKEDA , Florian PUENNER , Minoru NAKAMURA , Kazuaki TAKAMI , Masataka MURAKAMI , Masaki DAINI , Masaki SETO , Satoshi MIKAMI , Minoru SASAKI
IPC分类号: C07D213/82 , C07D401/12 , C07D471/04 , C07D413/12 , C07D405/14 , C07D401/14 , C07D237/14 , C07D405/12
摘要: The present invention provides a compound having a glucosylceramide synthase inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of lysosomal storage diseases (e.g., Gaucher's disease, Fabry's disease, GM1-gangliosidosis, GM2 activator deficiency, Tay-Sachs disease, Sandhoffs disease), neurodegenerative diseases (e.g., Parkinson's disease, Lewy body dementia, multiple-system atrophy) and the like.
The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the description, or a salt thereof.-
公开(公告)号:US20160347724A1
公开(公告)日:2016-12-01
申请号:US15117539
申请日:2015-02-12
IPC分类号: C07D261/04 , C07D413/10
CPC分类号: C07D261/04 , C07D413/10
摘要: A fused heterocyclic compound having an enteropeptidase inhibitory action and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided. Specifically, a compound represented by the following formula (I): wherein each symbol is as defined herein, or a salt thereof and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.
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公开(公告)号:US20220274982A1
公开(公告)日:2022-09-01
申请号:US17630840
申请日:2020-07-28
发明人: Yuta TANAKA , Yuta TANAKA , Fumiaki KIKUCHI , Takeshi YAMAMOTO , Minoru NAKAMURA , Kazuaki TAKAMI , Masataka MURAKAMI , Masaki DAINI , Yasufumi WADA , Keiko KAKEGAWA , Takahito KASAHARA , Tomohiro OHASHI , Junsi WANG , Zenichi IKEDA , Florian PUENNER , Masaki SETO , Satoshi MIKAMI , Minoru SASAKI
IPC分类号: C07D471/04
摘要: The present invention provides a compound having a glucosylceramide synthase inhibitory action, which is expected to be useful as an agent for the prophylaxis or treatment of lysosomal storage diseases (e.g., Gaucher's disease, Fabry's disease, GM1-gangliosidosis, GM2 activator deficiency, Tay-Sachs disease, Sandhoffs disease), neurodegenerative diseases (e.g., Parkinson's disease, Lewy body dementia, multiple-system atrophy) and the like.
The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the description, or a salt thereof.-
公开(公告)号:US20190135799A1
公开(公告)日:2019-05-09
申请号:US16049359
申请日:2018-07-30
发明人: Masahiro ITO , Hideyuki SUGIYAMA , Osamu KUBO , Fumiaki KIKUCHI , Takeshi YASUI , Keiko KAKEGAWA , Zenichi IKEDA , Tohru MIYAZAKI , Yasuyoshi ARIKAWA , Tomohiro OKAWA , Jinichi YONEMORI , Akinori TOITA , Takuto KOJIMA , Yasutomi ASANO , Ayumu SATO , Hironobu MAEZAKI , Shinobu SASAKI , Hironori KOKUBO , Misaki HOMMA , Minoru SASAKI , Yasuhiro IMAEDA
IPC分类号: C07D413/14 , C07D471/04 , A61P25/28 , C07D413/04 , C07D417/14
CPC分类号: C07D413/14 , A61P25/28 , C07D413/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要: The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of central nervous system diseases including neurodegenerative disease, and the like, and a medicament comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
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公开(公告)号:US20170349605A1
公开(公告)日:2017-12-07
申请号:US15539607
申请日:2015-12-24
发明人: Minoru SASAKI , Fumiaki KIKUCHI , Zenichi IKEDA , Keiko KAKEGAWA , Yoichi NISHIKAWA , Shigekazu SASAKI , Koichiro FUKUDA , Kazuaki TAKAMI , Yoshihiro BANNO , Masahiro KAMAURA
IPC分类号: C07D495/04 , C07D491/044 , C07D413/06 , C07D323/00 , C07D313/00 , C07D321/12 , C07D321/00 , C07D313/20 , C07D493/04 , C07D405/06
CPC分类号: C07D495/04 , A61K31/365 , A61K31/381 , A61K31/4025 , A61K31/422 , A61K31/662 , C07D313/00 , C07D313/20 , C07D321/00 , C07D321/12 , C07D323/00 , C07D405/06 , C07D409/12 , C07D413/06 , C07D491/044 , C07D493/04 , C07F9/655
摘要: The present invention relates to a condensed heterocyclic compound that has an enteropeptidase inhibitory effect and is useful in the treatment or prevention of obesity, diabetes mellitus, or the like, and a medicament containing the same. Specifically, the present invention relates to a compound represented by the following formula (I) or a salt thereof, and a medicament containing the same [in the formula, each symbol is as defined in the specification].
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公开(公告)号:US20210115048A1
公开(公告)日:2021-04-22
申请号:US16608723
申请日:2018-04-26
发明人: Shuji KITAMURA , Zenichi IKEDA , Minoru IKOMA , Koji WATANABE , Hideki HIROSE , Takafumi YUKAWA , Sachie MORIMOTO , Naoki NISHIZAWA , Taiji ASAMI
IPC分类号: C07D487/04 , A61P9/04 , A61K47/38 , A61K31/4184 , A61K9/48 , A61K9/20
摘要: The present invention provides a compound or a salt thereof having a calcium-sensing receptor antagonistic activity, and being expected to be useful as an agent for preventing or treating heart failure, pulmonary hypertension, or the like. The compounds represented by formula (I) or a salt thereof has a calcium-sensing receptor antagonistic activity, and is expected to be useful as an agent for preventing or treating heart failure, pulmonary hypertension, or the like, wherein each symbol is as described in the specification.
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公开(公告)号:US20180072694A1
公开(公告)日:2018-03-15
申请号:US15561613
申请日:2016-03-25
IPC分类号: C07D307/79 , C07D413/04 , C07F9/655
CPC分类号: C07D307/79 , A61K31/343 , A61K31/422 , A61K31/665 , A61P3/04 , A61P3/10 , C07D413/04 , C07F9/38 , C07F9/65517
摘要: The present invention relates to a condensed heterocyclic compound that has an enteropeptidase inhibitory effect, and use of the compound as a medicament for the treatment or prevention of obesity, diabetes mellitus, or the like. Specifically, the present invention relates to a compound represented by the formula (I) or a salt thereof, and use of the compound as a medicament for the treatment or prevention of obesity, diabetes mellitus, or the like [in the formula, each symbol is as defined in the specification].
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公开(公告)号:US20160355494A1
公开(公告)日:2016-12-08
申请号:US15117538
申请日:2015-02-12
IPC分类号: C07D307/81
CPC分类号: C07D307/81
摘要: A fused heterocyclic compound having an enteropeptidase inhibitory action and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided. Specifically, a compound represented by the following formula (I): wherein each symbol is as defined herein, or a salt thereof and use of the compound as a medicament for treatment or prophylaxis of obesity, diabetes mellitus, etc., are provided.
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公开(公告)号:US20150299188A1
公开(公告)日:2015-10-22
申请号:US14423310
申请日:2013-08-23
发明人: Masaki OGINO , Zenichi IKEDA , Jun FUJIMOTO , Yusuke OHBA , Naoki ISHII , Takuya FUJIMOTO , Tsuneo ODA , Naohiro TAYA , Toshiro YAMASHITA , Nobuyuki MATSUNAGA
IPC分类号: C07D471/04
CPC分类号: C07D471/04 , A61K9/2018 , A61K9/4858 , C07D239/80 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/12 , C07D413/04 , C07D417/12 , C07D487/04 , C07D513/04 , C07D519/00
摘要: Provided is a compound having a superior FLAP inhibitory action and useful as a prophylactic or therapeutic agent for arteriosclerosis and the like, and a salt thereof. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present DESCRIPTION, or a salt thereof.
摘要翻译: 提供具有优异的FLAP抑制作用并可用作动脉硬化等的预防或治疗剂及其盐的化合物。 本发明涉及由下式表示的化合物,其中各符号如本说明书所定义,或其盐。
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