公开(公告)号：US08450531B2

公开(公告)日：2013-05-28

申请号：US12979459

申请日：2010-12-28

申请人： Takeyuki Kondo ,  Masayuki Kamikawa ,  Kenichiro Oka ,  Toshiaki Matsuo ,  Masashi Tanto ,  Yasunari Sase ,  Hiroyuki Ito ,  Tomofumi Shiraishi ,  Tsutomu Kawamura ,  Naruyasu Okamoto

发明人： Takeyuki Kondo ,  Masayuki Kamikawa ,  Kenichiro Oka ,  Toshiaki Matsuo ,  Masashi Tanto ,  Yasunari Sase ,  Hiroyuki Ito ,  Tomofumi Shiraishi ,  Tsutomu Kawamura ,  Naruyasu Okamoto

IPC分类号： C07C45/64 ,  C07D307/46 ,  C07H1/00

CPC分类号： C07D307/48 ,  B01F5/0057 ,  B01F5/0615 ,  B01F5/0682 ,  B01F5/0688 ,  C07C45/52 ,  Y02P20/544 ,  C07C47/22

摘要： An object of the present invention is to provide a method for commercially manufacturing acrolein in a large flow rate by making supercritical water and an acid interact with glycerin, wherein by efficiently mixing high-concentration glycerin and supercritical water with each other, the method is made capable of making the synthesis stably proceed with a high yield while the occlusion and abrasion of the pipes and devices due to the generation of by-products are being suppressed. The method for synthesizing acrolein of the present invention is a method for synthesizing acrolein by making supercritical water and an acid interact with glycerin, the method using a reaction apparatus including: a cylindrical mixing flow path for mixing a fluid including glycerin and a fluid including supercritical water with each other; a first inlet flow path, disposed offset from the central axis of the mixing flow path, for making the fluid including glycerin flow into the mixing flow path; and a second inlet flow path, disposed offset from the central axis of the mixing flow path, for making the fluid including supercritical water flow into the mixing flow path, wherein the first inlet flow path and the second inlet flow path are each provided in a plurality of numbers in such a way that the first inlet flow paths and the second inlet flow paths are alternately arranged so as to encircle the central axis of the mixing flow path.

摘要翻译： 本发明的目的是提供一种通过使超临界水和酸与甘油相互作用而大量流动丙烯醛的方法，其中通过将高浓度甘油和超临界水相互有效地混合，制备方法 能够以高产率稳定地进行合成，同时由于副产物的产生而引起的管道和装置的堵塞和磨损被抑制。 本发明的丙烯醛的合成方法是通过使超临界水和酸与甘油相互作用来合成丙烯醛的方法，使用反应装置的方法包括：将含有甘油的液体和包含超临界流体的流体混合的圆筒状混合流路 水相互; 第一入口流动路径，设置为偏离混合流动路径的中心轴线，用于使包含甘油的流体流入混合流动路径; 以及第二入口流动路径，其设置成偏离混合流动路径的中心轴线，用于使包括超临界水流的流体流入混合流动路径，其中第一入口流动路径和第二入口流动路径分别设置在 多个数字，使得第一入口流动路径和第二入口流动路径交替地布置成环绕混合流动路径的中心轴线。

公开(公告)号：US20110160447A1

公开(公告)日：2011-06-30

申请号：US12979459

申请日：2010-12-28

申请人： Takeyuki KONDO ,  Masayuki Kamikawa ,  Kenichiro Oka ,  Toshiaki Matsuo ,  Masashi Tanto ,  Yasunari Sase ,  Hiroyuki Ito ,  Tomofumi Shiraishi ,  Tsutomu Kawamura ,  Naruyasu Okamoto

发明人： Takeyuki KONDO ,  Masayuki Kamikawa ,  Kenichiro Oka ,  Toshiaki Matsuo ,  Masashi Tanto ,  Yasunari Sase ,  Hiroyuki Ito ,  Tomofumi Shiraishi ,  Tsutomu Kawamura ,  Naruyasu Okamoto

IPC分类号： C08B37/00 ,  C07C45/61 ,  C07D307/34

CPC分类号： C07D307/48 ,  B01F5/0057 ,  B01F5/0615 ,  B01F5/0682 ,  B01F5/0688 ,  C07C45/52 ,  Y02P20/544 ,  C07C47/22

摘要： An object of the present invention is to provide a method for commercially manufacturing acrolein in a large flow rate by making supercritical water and an acid interact with glycerin, wherein by efficiently mixing high-concentration glycerin and supercritical water with each other, the method is made capable of making the synthesis stably proceed with a high yield while the occlusion and abrasion of the pipes and devices due to the generation of by-products are being suppressed. The method for synthesizing acrolein of the present invention is a method for synthesizing acrolein by making supercritical water and an acid interact with glycerin, the method using a reaction apparatus including: a cylindrical mixing flow path for mixing a fluid including glycerin and a fluid including supercritical water with each other; a first inlet flow path, disposed offset from the central axis of the mixing flow path, for making the fluid including glycerin flow into the mixing flow path; and a second inlet flow path, disposed offset from the central axis of the mixing flow path, for making the fluid including supercritical water flow into the mixing flow path, wherein the first inlet flow path and the second inlet flow path are each provided in a plurality of numbers in such a way that the first inlet flow paths and the second inlet flow paths are alternately arranged so as to encircle the central axis of the mixing flow path.

摘要翻译： 本发明的目的是提供一种通过使超临界水和酸与甘油相互作用而大量流动丙烯醛的方法，其中通过将高浓度甘油和超临界水相互有效地混合，制备方法 能够以高产率稳定地进行合成，同时由于副产物的产生而引起的管道和装置的堵塞和磨损被抑制。 本发明的丙烯醛的合成方法是通过使超临界水和酸与甘油相互作用来合成丙烯醛的方法，使用反应装置的方法包括：将含有甘油的液体和包含超临界流体的流体混合的圆筒状混合流路 水相互; 第一入口流动路径，设置为偏离混合流动路径的中心轴线，用于使包含甘油的流体流入混合流动路径; 以及第二入口流动路径，其设置成偏离混合流动路径的中心轴线，用于使包括超临界水流的流体流入混合流动路径，其中第一入口流动路径和第二入口流动路径分别设置在 多个数字，使得第一入口流动路径和第二入口流动路径交替地布置成环绕混合流动路径的中心轴线。

公开(公告)号：US20110171082A1

公开(公告)日：2011-07-14

申请号：US13060655

申请日：2009-08-12

申请人： Tomofumi Shiraishi ,  Tsutomu Kawamura ,  Takeyuki Kondo

发明人： Tomofumi Shiraishi ,  Tsutomu Kawamura ,  Takeyuki Kondo

IPC分类号： B01J19/00

CPC分类号： B01F5/0057 ,  B01J19/0093 ,  B01J19/2405 ,  B01J19/26 ,  B01J2219/00788 ,  B01J2219/00889

摘要： In order to provide, when a plurality of fluids each containing a different kind of substance are mixed and reacted, a reactor having a mixing channel capable of forming a multi-layered flow in a radial direction in the cylindrically-shaped mixing channel; improving mixing performance by synergizing swirling effects of mixture of turbulent flows and a swirling flow; and producing a reaction product with a high yield as well as high efficiency, a mixing channel 1 which mixes fluids 4 and 5 each containing the different kind of substance is cylindrically shaped, and inlet passages 2 and 3 which introduce the fluids 4 and 5, respectively, are plurally arranged in a manner offset from a central axis of the mixing channel 1.

摘要翻译： 为了提供将含有不同种类的物质的多种流体混合并反应的反应器，具有能够在圆筒状混合流路中沿径向形成多层流动的混合流路的反应器; 通过协同混合紊流和旋流的旋流效应来提高混合性能; 并且以高产率和高效率生产反应产物，混合每种含有不同种类物质的流体4和5的混合通道1是圆柱形的，并且引入流体4和5的入口通道2和3， 分别以与混合通道1的中心轴偏移的方式多个排列。

公开(公告)号：US08551417B2

公开(公告)日：2013-10-08

申请号：US13060655

申请日：2009-08-12

申请人： Tomofumi Shiraishi ,  Tsutomu Kawamura ,  Takeyuki Kondo

发明人： Tomofumi Shiraishi ,  Tsutomu Kawamura ,  Takeyuki Kondo

IPC分类号： B01J19/00 ,  B01F13/00

CPC分类号： B01F5/0057 ,  B01J19/0093 ,  B01J19/2405 ,  B01J19/26 ,  B01J2219/00788 ,  B01J2219/00889

摘要： In order to provide, when a plurality of fluids each containing a different kind of substance are mixed and reacted, a reactor having a mixing channel capable of forming a multi-layered flow in a radial direction in the cylindrically-shaped mixing channel; improving mixing performance by synergizing swirling effects of mixture of turbulent flows and a swirling flow; and producing a reaction product with a high yield as well as high efficiency, a mixing channel 1 which mixes fluids 4 and 5 each containing the different kind of substance is cylindrically shaped, and inlet passages 2 and 3 which introduce the fluids 4 and 5, respectively, are plurally arranged in a manner offset from a central axis of the mixing channel 1.

摘要翻译： 为了提供将含有不同种类的物质的多种流体混合并反应的反应器，具有能够在圆筒状混合流路中沿径向形成多层流动的混合流路的反应器; 通过协同混合紊流和旋流的旋流效应来提高混合性能; 并且以高产率和高效率生产反应产物，混合每种含有不同种类物质的流体4和5的混合通道1是圆柱形的，并且引入流体4和5的入口通道2和3， 分别以与混合通道1的中心轴偏移的方式多个排列。

公开(公告)号：US20080175768A1

公开(公告)日：2008-07-24

申请号：US11829147

申请日：2007-07-27

申请人： Tadashi Sano ,  Mio Suzuki ,  Yukako Asano ,  Shigenori Togashi ,  Tsutomu Kawamura ,  Tomofumi Shiraishi

发明人： Tadashi Sano ,  Mio Suzuki ,  Yukako Asano ,  Shigenori Togashi ,  Tsutomu Kawamura ,  Tomofumi Shiraishi

IPC分类号： B01J19/00 ,  F28D21/00

CPC分类号： B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01J2219/00891

摘要： There is provided a reaction apparatus which is capable of keeping the pressure inside the reactor and is applicable to various fields. This reaction apparatus comprises: a raw material tank (2) for storing a raw material; a high-pressure pump (3) communicated with the raw material tank (2) and designed to deliver the raw material therefrom; a reactor (1) which is disposed on the downstream side of the high-pressure pump (3) and designed to be supplied with the raw material in a compressed state; a heating bath (11) for heating the reactor (1) to promote a reaction; and a product tank (7) for receiving and recovering a product; wherein the reaction apparatus is further equipped with an inlet port which is interposed between the heating bath (11) and the product tank (7), and with an injection pump (6) for injecting an injecting liquid through the inlet port, whereby a pressure of product flowing into the product tank (7) is enabled to be reduced by making use of the flow rate of the injecting liquid.

摘要翻译： 提供了能够保持反应器内的压力并适用于各种领域的反应装置。 该反应装置包括：原料罐（2），用于储存原料; 与原料罐（2）连通并设计成从原料罐（2）输送原料的高压泵（3） 反应器（1），其设置在所述高压泵（3）的下游侧并设计成以压缩状态供给所述原料; 用于加热反应器（1）以促进反应的加热浴（11） 和用于接收和回收产品的产品罐（7）; 其特征在于，所述反应装置还具有插入在所述加热槽（11）和所述产品罐（7）之间的入口端口，以及用于通过所述入口喷射注入液体的注入泵（6） 能够通过利用注射液的流量来减少流入产品罐（7）的产品。

公开(公告)号：US20060210444A1

公开(公告)日：2006-09-21

申请号：US11375114

申请日：2006-03-15

申请人： Yukako Asano ,  Shigenori Togashi ,  Masashi Oda ,  Tomofumi Shiraishi ,  Tsutomu Kawamura

发明人： Yukako Asano ,  Shigenori Togashi ,  Masashi Oda ,  Tomofumi Shiraishi ,  Tsutomu Kawamura

IPC分类号： B01L3/00

CPC分类号： B01J19/0093 ,  B01F13/0059 ,  B01F13/0093 ,  B01J2219/00822 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00961 ,  B01J2219/00984 ,  B01J2219/00986 ,  B01J2219/00995 ,  F28D2021/0077

摘要： There is provided means for increasing a yield and a selectivity of objective substancean objective substance in a consecutive reaction. A substance manufacturing equipment for reacting a substance A and a substance B that can perform a consecutive reaction to produce a product of a first stage reaction as an objective substance, including: a microchannel; a mixing portion including a channel for introducing a solution containing the substance A into the microchannel and a channel for introducing a solution containing the substance B into the microchannel; and a temperature control equipment for controlling a temperature of a reaction system in the microchannel, wherein the temperature control equipment controls the temperature of the reaction system in the microchannel within a temperature range higher than a reaction temperature by a batch method and lower than a boiling point of the reaction system.

摘要翻译： 提供了在连续反应中提高目标物质的产率和选择性的方法。 一种使物质A和物质B反应的物质制造设备，其可以进行连续反应以产生作为目标物质的第一级反应的产物，包括：微通道; 混合部分，其包括用于将含有物质A的溶液引入微通道的通道和用于将含有物质B的溶液引入微通道的通道; 以及用于控制微通道中的反应系统的温度的温度控制设备，其中温度控制设备通过间歇法控制微通道内的反应体系在比反应温度高的温度范围内的温度，并且低于沸点 点反应体系。

公开(公告)号：US07901639B2

公开(公告)日：2011-03-08

申请号：US11829147

申请日：2007-07-27

申请人： Tadashi Sano ,  Mio Suzuki ,  Yukako Asano ,  Shigenori Togashi ,  Tsutomu Kawamura ,  Tomofumi Shiraishi

发明人： Tadashi Sano ,  Mio Suzuki ,  Yukako Asano ,  Shigenori Togashi ,  Tsutomu Kawamura ,  Tomofumi Shiraishi

IPC分类号： B01J19/00 ,  C07B59/00

CPC分类号： B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01J2219/00891

摘要： There is provided a reaction apparatus which is capable of keeping the pressure inside the reactor and is applicable to various fields. This reaction apparatus comprises: a raw material tank (2) for storing a raw material; a high-pressure pump (3) communicated with the raw material tank (2) and designed to deliver the raw material therefrom; a reactor (1) which is disposed on the downstream side of the high-pressure pump (3) and designed to be supplied with the raw material in a compressed state; a heating bath (11) for heating the reactor (1) to promote a reaction; and a product tank (7) for receiving and recovering a product; wherein the reaction apparatus is further equipped with an inlet port which is interposed between the heating bath (11) and the product tank (7), and with an injection pump (6) for injecting an injecting liquid through the inlet port, whereby a pressure of product flowing into the product tank (7) is enabled to be reduced by making use of the flow rate of the injecting liquid.

摘要翻译： 提供了能够保持反应器内的压力并适用于各种领域的反应装置。 该反应装置包括：原料罐（2），用于储存原料; 与原料罐（2）连通并设计成从原料罐（2）输送原料的高压泵（3） 反应器（1），其设置在所述高压泵（3）的下游侧并设计成以压缩状态供给所述原料; 用于加热反应器（1）以促进反应的加热浴（11） 和用于接收和回收产品的产品罐（7）; 其特征在于，所述反应装置还具有插入在所述加热槽（11）和所述产品罐（7）之间的入口端口，以及用于通过所述入口喷射注入液体的注入泵（6） 能够通过利用注射液的流量来减少流入产品罐（7）的产品。

公开(公告)号：US20060216761A1

公开(公告)日：2006-09-28

申请号：US10516260

申请日：2003-05-30

申请人： Kyoichi Saito ,  Tomofumi Shiraishi ,  Yasuhiro Goda

发明人： Kyoichi Saito ,  Tomofumi Shiraishi ,  Yasuhiro Goda

IPC分类号： G01N33/542 ,  B32B27/04 ,  C12M1/34

CPC分类号： B01J20/26 ,  B01J20/261 ,  B01J20/262 ,  B01J20/264 ,  B01J20/28014 ,  B01J20/28033 ,  B01J20/28038 ,  B01J20/286 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3217 ,  B01J20/3219 ,  B01J20/3255 ,  B01J20/3274 ,  B01J20/3278 ,  B01J2220/54 ,  B01J2220/58 ,  G01N33/74 ,  Y10T442/2525

摘要： The present invention relates to an isolation material for an endocrine disrupter, which is prepared by immobilizing an anti-endocrine disrupter antibody to a graft-chain-containing carrier made of a polymeric material via covalent binding. According to the present invention, an isolation material for an endocrine disrupter, which is capable of specific and efficient isolation of an endocrine disruptor, and an endocrine disrupter concentration and a clean-up method capable of specific and efficient concentration or clean-up of an endocrine disruptor at a high rate can be afforded.

摘要翻译： 本发明涉及用于内分泌干扰物的分离材料，其通过将抗内分泌干扰物抗体通过共价结合固定在由聚合物材料制成的含接枝链的载体上而制备。 根据本发明，能够特异且有效地分离内分泌干扰物的内分泌干扰物分离材料和内分泌干扰物浓度以及清洁方法能够特异性和有效地浓缩或清除 可以提供高分辨率的内分泌干扰物。