摘要:
The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp-Leu- A27-A28-A29-Y. The present invention also provides a pharmaceutical composition comprising the GIP analog and use thereof.
摘要翻译:本发明提供衍生自GIP(1-29,SEQ ID NO:1)的GIP类似物具有GLP-1激动剂活性和GIPR刺激活性,并且包含由下式I表示的氨基酸序列: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp- Leu- A27-A28-A29-Y。 本发明还提供了包含GIP类似物及其用途的药物组合物。
摘要:
The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp-Leu-A27-A28-A29-Y. The present invention also provides a pharmaceutical composition comprising the GIP analog and use thereof.
摘要翻译:本发明提供衍生自GIP(1-29,SEQ ID NO:1)的GIP类似物具有GLP-1激动剂活性和GIPR刺激活性,并且包含由下式I表示的氨基酸序列: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp- Leu-A27-A28-A29-Y。 本发明还提供了包含GIP类似物及其用途的药物组合物。
摘要:
Techniques, systems, and devices are disclosed for safely transporting passengers from pickup locations to destination locations on-demand using automated/pilotless vertical takeoff and landing (VTOL) aircraft. In one implementation, an on-demand passenger transport system includes one or more VTOL aircraft which operate without human pilots, and each of the VTOL aircraft operates under the control of an associated onboard computer. The disclosed system further includes a ground control system which is configured to: receive a service request from a passenger for a transport service of the VTOL aircraft; assign one of the VTOL aircraft to the requesting passenger; process the service request to generate a flight task; transmit the flight task to the assigned VTOL aircraft. The onboard computer of the VTOL aircraft is configured to control a flight of the VTOL aircraft to transport the passenger from a pickup location to a destination location by air based on the flight task.
摘要:
The present invention discloses an apparatus for baking a glass substrate, which includes: a baking oven, a support component, a temperature sensing device, a heating device, a cooling device, and a temperature controlling device. The present invention further discloses a method for baking a glass substrate. The present invention is capable of dynamically controlling the temperature of the support component, which contacts the glass substrate. The temperature of the glass substrate keeps identical and the temperature of the support component keep identical, so as to prevent a Mura defect appearing on the glass substrate.
摘要:
A method and a device for recording media are provided. The method includes performing a media recording process. During the media recording process, periodically media index information are generated according to currently written media chunks. The generated media index information is saved.
摘要:
An upper-bearing typed movable formwork used for cast-in-situ of concrete box girder in bridge engineering, comprising left and right legs (7) which are respectively fixed on a pier, left and right longitudinal/transverse sliding mechanisms (9), bearing devices and a template system. The left and right longitudinal/transverse sliding mechanisms (9) are respectively arranged on the left and right legs (7) and can move horizontally along the left and right legs (7), the bearing devices are respectively fixed on the left and right longitudinal/transverse sliding mechanisms (9), the template system comprises a bottom formwork (6), an internal formwork (3), a left formwork and a right formwork, the bottom formwork (6) is formed by screw connection of a left bottom formwork and a right bottom formwork (6a,6b) which are symmetrical about the axis line of the concrete box girder, two ends of the bottom formwork are respectively fixed on two opposite internal side surfaces of the left main beam and the right main beam (1). The movable formwork also comprises a plurality of adjustable supporting rods (14) used for supporting the template system.
摘要:
Provided herein are peptide combinations comprising a GIP agonist peptide and a glucagon antagonist peptide. In some embodiments, the peptide combination is provided as a composition, e.g., a pharmaceutical composition, while in other embodiments, the peptide combination is provided as a kit. In yet other embodiments, the peptide combination is provided as a conjugate, e.g., a fusion peptide, a heterodimer. In specific aspects, the GIP agonist peptide is an analog of native human glucagon. In specific aspects, the glucagon antagonist peptide is an analog of native human glucagon. In some embodiments, the GIP agonist peptide is covalently attached to the glucagon antagonist peptide via a linker. Methods of treating a disease, e.g., a metabolic disorder, such as diabetes and obesity, comprising administering the peptide compositions described herein are further provided.
摘要:
In one aspect, a system for safely landing a vertical takeoff-and-landing (VTOL) aircraft in the air onto a landing pad on the ground is disclosed. The system can begin by determining an estimated location of the landing pad with a first accuracy. The system then reduces a height of the VTOL aircraft to a first level above the ground while approaching the estimated location of the landing pad. Next, the system determines an updated location of the landing pad with a second accuracy. The system subsequently reduces the height of the VTOL aircraft to a second level above the ground while approaching the updated location of the landing pad. Next, the system aligns a center point of the VTOL aircraft with a center location of the landing pad. Finally, the system lands the VTOL aircraft onto the landing pad by directly lowering the VTOL aircraft onto the landing pad.
摘要:
Glucagon peptides with increased GIP activity are provided, optionally with GLP-I and/or glucagon activity. In some embodiments, C-terminally extended glucagon peptides comprising an amino acid sequence substantially similar to native glucagon are provided herein.