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    Natural composition to decrease effects of a high fat diet
    3.
    发明授权
    Natural composition to decrease effects of a high fat diet 有权
    天然成分降低高脂肪饮食的作用

    公开(公告)号：US09072762B2

    公开(公告)日：2015-07-07

    申请号：US13746630

    申请日：2013-01-22

    申请人： Zhijun Liu ,  Peiying Yang

    发明人： Zhijun Liu ,  Peiying Yang

    IPC分类号： A61K31/704 ,  A61K31/192 ,  A61K31/366

    CPC分类号： A61K31/704 ,  A61K31/192 ,  A61K31/366 ,  A61K2300/00

    摘要： The combination of gallic acid, ellagic acid, and rubusoside was shown to inhibit angiogenesis by inhibition of pro-angiogenic factors. These three compounds were shown to be absorbed from the intestine making the compounds orally bioavailable. The ratio of the three compounds in the composition was a weight ratio of approximately 1:1.7:17.0 of gallic acid, ellagic acid, and rubusoside, respectively, resulting in a composition with 5% w/w gallic acid, 9% w/w ellagic acid, and 86% w/w rubusoside. This combination was also shown to reduce weight gain, fat accumulation, and serum cholesterol in mammals fed a high fat diet. It also reduced serum triglycerides and tended to reduce blood glucose in mammals on both normal and high fat diets. This three-compound composition (“GER”) can be used to treat diseases associated with angiogenesis and to decrease effects of a high fat diet.

    摘要翻译： 没食子酸，鞣花酸和罗红糖苷的组合显示通过抑制促血管生成因子抑制血管生成。 这三种化合物被显示为从肠中吸收，使化合物口服生物可利用。 组合物中三种化合物的比例分别为没食子酸，鞣花酸和罗红糖苷的约1:1.7:17.0的重量比，得到具有5％w / w没食子酸的组成，9％w / w 鞣花酸和86％w / w的Rubusoside。 这种组合也显示出降低饲喂高脂肪饮食的哺乳动物体重增加，脂肪积累和血清胆固醇。 它还减少血清甘油三酯，并倾向于降低哺乳动物在正常和高脂肪饮食中的血糖。 这种三重化合物（“GER”）可用于治疗与血管生成相关的疾病，并降低高脂肪饮食的作用。

    Natural Composition to Decrease Effects of a High Fat Diet
    4.
    发明申请
    Natural Composition to Decrease Effects of a High Fat Diet 审中-公开
    天然成分降低高脂肪饮食的影响

    公开(公告)号：US20140206634A1

    公开(公告)日：2014-07-24

    申请号：US13746630

    申请日：2013-01-22

    申请人： Zhijun Liu ,  Peiying Yang

    发明人： Zhijun Liu ,  Peiying Yang

    IPC分类号： A61K31/704 ,  A61K31/366 ,  A61K31/192

    CPC分类号： A61K31/704 ,  A61K31/192 ,  A61K31/366 ,  A61K2300/00

    摘要： The combination of gallic acid, ellagic acid, and rubusoside was shown to inhibit angiogenesis by inhibition of pro-angiogenic factors. These three compounds were shown to be absorbed from the intestine making the compounds orally bioavailable. The ratio of the three compounds in the composition was a weight ratio of approximately 1:1.7:17.0 of gallic acid, ellagic acid, and rubusoside, respectively, resulting in a composition with 5% w/w gallic acid, 9% w/w ellagic acid, and 86% w/w rubusoside. This combination was also shown to reduce weight gain, fat accumulation, and serum cholesterol in mammals fed a high fat diet. It also reduced serum triglycerides and tended to reduce blood glucose in mammals on both normal and high fat diets. This three-compound composition (“GER”) can be used to treat diseases associated with angiogenesis and to decrease effects of a high fat diet.

    摘要翻译： 没食子酸，鞣花酸和罗红糖苷的组合显示通过抑制促血管生成因子抑制血管生成。 这三种化合物被显示为从肠中吸收，使化合物口服生物可利用。 组合物中三种化合物的比例分别为没食子酸，鞣花酸和罗红糖苷的约1:1.7:17.0的重量比，得到具有5％w / w没食子酸的组成，9％w / w 鞣花酸和86％w / w的Rubusoside。 这种组合也显示出降低饲喂高脂肪饮食的哺乳动物体重增加，脂肪积累和血清胆固醇。 它还减少血清甘油三酯，并倾向于降低哺乳动物在正常和高脂肪饮食中的血糖。 这种三重化合物（“GER”）可用于治疗与血管生成相关的疾病，并降低高脂肪饮食的作用。

    Sweet Gum Fruit Extract as a Therapeutic Agent
    6.
    发明申请
    Sweet Gum Fruit Extract as a Therapeutic Agent 审中-公开
    甜胶提取物作为治疗剂

    公开(公告)号：US20100189830A1

    公开(公告)日：2010-07-29

    申请号：US12600751

    申请日：2008-05-21

    申请人： Zhijun Liu ,  Peiying Yang ,  Robert A. Newman

    发明人： Zhijun Liu ,  Peiying Yang ,  Robert A. Newman

    IPC分类号： A61K36/185 ,  A61P25/28 ,  A61P9/10 ,  A61P9/12 ,  A61P3/10 ,  A61P37/06

    CPC分类号： A61K36/185 ,  A61K45/06

    摘要： Sweet gum (Liquidambar styraciflua L., family Hamamelidaceae) fruit extract was discovered to possess potent activities against multiple targets of the PBK (phosphatidylinositide 3-kinase) pathway, especially the PI3K/Akt and mTOR pathways. At a very low concentration of 1.85 μg/ml (IC50), sweet gun extract showed the ability of simultaneously blocking the pathways of PI3K/Akt (upstream), mTOR (mammalian target of rapamycin) (downstream), as well as its downstream protein products S6K and S6. It was also able to block 5-HETE, a lipoxygenase product that contributes to inflammation and activation of PI3K/Akt. The sweet gum fruit extract was prepared with 50% methanol (47:1; raw to extract) and concentrated to an organic fraction (210:1 raw to extract) referred as LIS-100 via reverse-phase column chromatography using a bioassay directed fractionation approach. The extract is a new targeted therapeutic agent for numerous disorders known to be treated by mTOR inhibitors, including cancer, diabetes, obesity, and inflammation.

    摘要翻译： 发现甜口香糖（枫香香a，，家amel科）水果提取物具有针对PBK（磷脂酰肌醇3-激酶）途径的多个靶点，特别是PI3K / Akt和mTOR途径的有效活性。 在1.85μg/ ml（IC 50）的非常低的浓度下，甜枪提取物显示同时阻断PI3K / Akt（上游），mTOR（雷帕霉素的哺乳动物靶标）（下游）以及其下游蛋白的途径的能力 产品S6K和S6。 它还能够阻断5-HETE，一种有助于PI3K / Akt的炎症和活化的脂氧合酶产物。 用50％甲醇（47:1，未加萃取物）制备甜口香糖果提取物，并通过反相柱色谱法使用生物测定方向分馏法浓缩成称为LIS-100的有机级分（210:1原始提取物） 方法 提取物是已知用mTOR抑制剂治疗的许多病症的新靶向治疗剂，包括癌症，糖尿病，肥胖症和炎症。

    Fuzzy logic winder analyzer
    7.
    发明授权
    Fuzzy logic winder analyzer 失效
    模糊逻辑络筒分析仪

    公开(公告)号：US6047275A

    公开(公告)日：2000-04-04

    申请号：US950009

    申请日：1997-10-14

    申请人： Todd R. Jaremko ,  Zhijun Liu

    发明人： Todd R. Jaremko ,  Zhijun Liu

    IPC分类号： B65H23/195 ,  G05B13/02 ,  G06F15/00

    CPC分类号： B65H23/1955 ,  G05B13/0275

    摘要： A method and apparatus for controlling tension of a material on a winder by controlling the torque on the winder using a fuzzy logic controller which automatically determines various material and operating characteristics and adjusts torque as a function of the determined characteristics including material density, spindle inertia, material acceleration and diameter of material accumulated on a spindle.

    摘要翻译： 一种用于通过使用模糊逻辑控制器控制卷绕机上的扭矩来控制卷绕机上的材料的张力的方法和装置，该模糊逻辑控制器根据所确定的特性自动确定各种材料和操作特性并调节扭矩，包括材料密度，主轴惯性， 材料加速度和主轴上积累的材料直径。

    Fault identification techniques for high resistance grounded systems
    9.
    发明授权
    Fault identification techniques for high resistance grounded systems 有权
    高电阻接地系统的故障识别技术

    公开(公告)号：US09091742B2

    公开(公告)日：2015-07-28

    申请号：US13400537

    申请日：2012-02-20

    申请人： Lixiang Wei ,  Zhijun Liu

    发明人： Lixiang Wei ,  Zhijun Liu

    IPC分类号： G01R31/00 ,  G01R31/42 ,  G01R31/02

    CPC分类号： G01R31/42 ,  G01R31/025

    摘要： The present techniques include methods and systems for detecting a high resistive ground fault condition in an HRG system. Embodiments include systems and methods of measuring drive voltages and detecting voltage changes in the drive once the drive is in operation, particularly for drives operating at relatively low voltages and frequencies. In some embodiments, an integrator is utilized to detect peaks in the measured voltage changes. Relatively small ground currents are also measured to determine HRG faults. Moreover, in some embodiments, the detection of an HRG fault for one of several motor drives provide indication for the particular motor drive in fault.

    摘要翻译： 本技术包括用于检测HRG系统中的高电阻接地故障状况的方法和系统。 实施例包括测量驱动电压并检测驱动器运行中的电压变化的系统和方法，特别是对于在较低电压和频率下工作的驱动器。 在一些实施例中，使用积分器来检测所测量的电压变化中的峰值。 还测量相对较小的接地电流以确定HRG故障。 此外，在一些实施例中，几个电动机驱动器之一的HRG故障的检测为故障中的特定电机驱动器提供指示。

    Parallel link reset in link based system
    10.
    发明授权
    Parallel link reset in link based system 有权
    基于链路的系统并行链路复位

    公开(公告)号：US07805597B2

    公开(公告)日：2010-09-28

    申请号：US11731064

    申请日：2007-03-30

    申请人： Xiaohua Cai ,  Yufu Li ,  Zhijun Liu ,  Geng Tian

    发明人： Xiaohua Cai ,  Yufu Li ,  Zhijun Liu ,  Geng Tian

    IPC分类号： G06F9/00 ,  G06F9/24 ,  G06F15/177

    CPC分类号： G06F15/16

    摘要： A link based system including a plurality of processors is reset when transitioning from a slower speed to a higher speed mode during a booting process. One processor may coordinate the simultaneous establishment of link resetting of a plurality of other processors. In one embodiment, the processors may operate beginning with the farthest processor to reset their local links. Each processor sets its local links and if it determines, based on the speed of the link that the link has already been reset, it moves on to the next link.

    摘要翻译： 包括多个处理器的基于链路的系统在引导过程期间从较慢速度转换到较高速度模式时被复位。 一个处理器可以协调同时建立多个其他处理器的链路重置。 在一个实施例中，处理器可以从最远的处理器开始操作以重置其本地链路。 每个处理器设置其本地链路，并且如果它根据链路已经被重置的链路的速度来确定它移动到下一个链路。