公开(公告)号：US20060127329A1

公开(公告)日：2006-06-15

申请号：US11256789

申请日：2005-10-24

申请人： Tao Xu ,  Susan Herles ,  James Brown ,  Virginia Barnes ,  Rose Richter ,  Michael Prencipe

发明人： Tao Xu ,  Susan Herles ,  James Brown ,  Virginia Barnes ,  Rose Richter ,  Michael Prencipe

IPC分类号： A61K36/575 ,  A61K8/46 ,  A61K8/97

CPC分类号： A61Q11/00 ,  A61K8/24 ,  A61K8/347 ,  A61K8/97

摘要： A stable and efficacious antiplaque, anticalculus, and antigingivitis oral composition is provided having an antibacterial ingredient comprising one or more active compounds found in an extract of magnolia combined with an anticalculus system comprising tetrasodium pyrophosphate (TSPP) about 1 to about 2.5% and sodium tripolyphosphate (STPP) about 1 to about 10%. The oral composition can be in the form of a mouth rinse or dentifrice, including toothpaste, gels, powders, as well as confectionaries, lozenges, and the like. Methods of making and using the oral composition are also provided.

摘要翻译： 提供了一种稳定有效的抗牙龈，抗牙龈炎和抗呼吸道炎口腔组合物，其具有包含在木兰提取物中发现的一种或多种活性化合物的抗菌成分，其与包含约1至约2.5％的焦磷酸四钠（TSPP）和约三聚磷酸钠 （STPP）约1至约10％。 口腔组合物可以是漱口剂或洁齿剂的形式，包括牙膏，凝胶，粉末，以及糖果，锭剂等。 还提供了制备和使用口腔组合物的方法。

公开(公告)号：US20060140879A1

公开(公告)日：2006-06-29

申请号：US11023968

申请日：2004-12-28

申请人： Linh Fruge ,  James Brown ,  Susan Herles ,  Kimberlee Panaligan ,  Evangelia Arvanitidou ,  Nebojsa Milanovich ,  Michael Prencipe

发明人： Linh Fruge ,  James Brown ,  Susan Herles ,  Kimberlee Panaligan ,  Evangelia Arvanitidou ,  Nebojsa Milanovich ,  Michael Prencipe

IPC分类号： A61K8/21

CPC分类号： A61K8/21 ,  A61K8/19 ,  A61K8/347 ,  A61K2800/88 ,  A61Q11/00

摘要： An oral care composition having a first phase of clinically efficacious 2,4,4′-trichloro 2′-hydroxydiphenyl ether admixed in a first orally acceptable aqueous vehicle, and a second phase having a stannous salt (such as stannous fluoride) admixed in a second orally acceptable aqueous vehicle. The second phase has no less than 10 molar percent of soluble stannous ion respective to a mathematical sum of moles of the soluble stannous ion and moles of the stannous salt in the second phase. In one embodiment, the two phases are provided in a dual-tube toothpaste oral care kit.

摘要翻译： 一种口腔护理组合物，其具有混合在第一口服可接受的水性载体中的临床上有效的2,4,4'-三氯2'-羟基二苯醚的第一相，和在其中混合的具有亚锡盐（例如氟化亚锡）的第二相 第二种口服可接受的水性载体。 第二相具有不少于10摩尔％的可溶性亚锡离子，相对于第二相中可溶性亚锡离子的摩尔数和亚锡盐的摩尔数的数学和。 在一个实施方案中，将两相设置在双管牙膏口腔护理套件中。

公开(公告)号：US20140126949A1

公开(公告)日：2014-05-08

申请号：US14068905

申请日：2013-10-31

申请人： Jack W. Kaufman ,  James Brown

发明人： Jack W. Kaufman ,  James Brown

IPC分类号： A61F13/40

CPC分类号： A61M35/006 ,  A45D34/04 ,  A45D2200/1018 ,  A61L2/00 ,  A61L2/18 ,  A61M35/003 ,  A61M2205/273 ,  B43M11/06

摘要： A single-piece, injection molded, hand-held liquid dispensing applicator. The single-piece applicator comprising a source of fluid and a frangible applicator tip attached to the fluid source. When the frangible applicator tip is broken, the fluid flows from the source to an absorbent member attached to the applicator tip to spread the liquid on a surface. The frangible tip may comprise a support element permanently connected to the fluid source, a relatively rigid tongue element, and a frangible region therebetween. The tongue element may comprise ribs for reinforcement. The frangible tip may comprise a semi-permeable or non-permeable cover to control the speed and direction of the dispersion of the fluid. The dispensing applicator may be used in various medical applications.

摘要翻译： 单件式注射成型的手持液体分配器。 单件式涂布器包括流体源和连接到流体源的易碎施用器尖端。 当易碎的施用器尖端断裂时，流体从源极流到附接到施用器尖端的吸收构件，以将液体扩散在表面上。 易碎尖端可以包括永久地连接到流体源的支撑元件，相对刚性的舌元件以及它们之间的易碎区域。 舌元件可以包括用于加强的肋。 易碎的尖端可以包括半渗透或不可渗透的盖，以控制流体的分散体的速度和方向。 分配施加器可以用于各种医疗应用中。

公开(公告)号：US08573542B2

公开(公告)日：2013-11-05

申请号：US12855793

申请日：2010-08-13

申请人： James Brown

发明人： James Brown

IPC分类号： B64C3/00

CPC分类号： B64C21/04 ,  Y02T50/166

摘要： An aerofoil defining geometric upper and lower surfaces which together form a leading edge region and a trailing edge region, and comprising a blowing device having a slot in the lower geometric surface in the leading edge region for injecting fluid into the airflow over the aerofoil, wherein the slot is located forward of the leading edge stagnation point at the critical angle of incidence of the aerofoil, and wherein the blowing device is adapted to inject the fluid forwardly of the slot and substantially parallel to the lower surface. Also, a method of improving the performance of the aerofoil by injecting fluid into the airflow over the aerofoil from the slot. The upper surface of the aerofoil can be kept clean, giving the potential for laminar flow during cruise without significantly compromising the high lift performance of a blown leading edge at high incidence.

摘要翻译： 机翼限定几何上下表面，它们一起形成前缘区域和后缘区域，并且包括吹风装置，该吹风装置在前缘区域中的下几何表面中具有狭槽，用于将流体喷射到机翼上的气流中，其中 所述槽位于所述翼缘的临界入射角处的所述前缘停滞点的前方，并且其中所述吹风装置适于将所述流体向前注入并基本上平行于所述下表面。 而且，一种通过将流体从狭槽喷射到机翼上的空气中来提高机翼的性能的方法。 机翼的上表面可以保持清洁，在巡航期间具有层流的潜力，而不会显着损害高发射时的吹风前缘的高提升性能。

公开(公告)号：US08511923B2

公开(公告)日：2013-08-20

申请号：US13455620

申请日：2012-04-25

申请人： Jack W. Kaufman ,  James Brown

发明人： Jack W. Kaufman ,  James Brown

IPC分类号： B43K5/14

CPC分类号： A61M35/006 ,  A45D34/042 ,  A61M35/003 ,  B43M11/06

摘要： A hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region there between. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member.

摘要翻译： 一种手持式分配器，其包括流体源，连接到流体源的易碎施用器尖端以及附接到易碎施用器尖端的吸收构件。 当易碎的施用器尖端被破坏时，流体从源流向吸收构件，由此将流体施加并扩散在表面上。 优选地，易碎的施用器尖端包括永久地连接到流体源的支撑元件，从支撑元件向外延伸的相对刚性的舌元件以及其间的易碎区域。 更优选地，施用器末端包括设置在易碎区域周围的半透性或不可渗透的盖，以控制吸收构件中的流体分散体的速度和方向。

公开(公告)号：US20130028651A1

公开(公告)日：2013-01-31

申请号：US13601755

申请日：2012-08-31

申请人： James Brown ,  Janet P. Kaufman

发明人： Jack W. Kaufman ,  James Brown

IPC分类号： B05C17/00

CPC分类号： A61M35/006 ,  A45D34/04 ,  A45D2200/1018 ,  A61L2/00 ,  A61L2/18 ,  A61M35/003 ,  A61M2205/273 ,  B43M11/06

摘要： A hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. The applicator may be applicable for a medical purpose. When the frangible applicator tip is broken, the fluid flows from the source to the absorbent member, spread on a surface. The frangible applicator tip may comprise a support element permanently connected to the fluid source, a relatively rigid tongue element, and a frangible region there between. The tongue element may comprise ribs for reinforcing the tongue element. The applicator tip may comprise a semi-permeable or non-permeable cover to control the speed and direction of the dispersion of the fluid.

摘要翻译： 一种手持式分配器，其包括流体源，连接到流体源的易碎施用器尖端以及附接到易碎施用器尖端的吸收构件。 施用器可以适用于医疗目的。 当易碎的施用器尖端被破坏时，流体从源流向吸收构件，扩散在表面上。 易碎的施用器尖端可以包括永久地连接到流体源的支撑元件，相对刚性的舌元件以及其间的易碎区域。 舌元件可以包括用于加强舌元件的肋。 施用器尖端可以包括半渗透性或不可渗透的覆盖物，以控制流体的分散体的速度和方向。

公开(公告)号：US20130018064A1

公开(公告)日：2013-01-17

申请号：US13511360

申请日：2010-11-19

申请人： Nick A. Paras ,  Yuan Cheng ,  Timothy Powers ,  James Brown ,  Stephen A. Hitchcock ,  Ted Judd ,  Patricia Lopez ,  Qiufen Xue ,  Bryant Yang

发明人： Nick A. Paras ,  Yuan Cheng ,  Timothy Powers ,  James Brown ,  Stephen A. Hitchcock ,  Ted Judd ,  Patricia Lopez ,  Qiufen Xue ,  Bryant Yang

IPC分类号： A61K31/506 ,  A61P25/28 ,  A61K31/4709 ,  C07D401/08 ,  C07D401/06

CPC分类号： C07D401/06 ,  C07D401/12 ,  C07D401/14

摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I, wherein ring A, B1, B2, B3, L, R1, R4, ring Z, m and p of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease (AD), cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

摘要翻译： 本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。 在一个实施方案中，化合物具有通式I，其中式I的环A，B 1，B 2，B 3，L，R 1，R 4，环Z，m和p如本文所定义。 本发明还包括在药物组合物中用于治疗，预防或治疗与β-分泌酶蛋白活性相关的病症和病症的用途。 这些疾病包括例如阿尔茨海默氏病（AD），认知缺陷，认知障碍，精神分裂症和与脑上形成和/或沉积斑块相关和/或引起的其他中枢神经系统病症。 本发明还包括式I的其它实施方案，可用于制备式I化合物的中间体和方法。

公开(公告)号：US08316869B2

公开(公告)日：2012-11-27

申请号：US12871286

申请日：2010-08-30

申请人： Pejman Fani ,  Mark Rouillard ,  John Korbler ,  James Brown ,  Chad Hosack

发明人： Pejman Fani ,  Mark Rouillard ,  John Korbler ,  James Brown ,  Chad Hosack

IPC分类号： B08B3/00

CPC分类号： H01L21/02057 ,  B08B3/04 ,  B08B3/10 ,  B08B3/12 ,  H01L21/67051

摘要： A system, apparatus and method for processing flat articles with acoustical energy. The inventive system, apparatus and method can remove particles from both sides of a wafer more efficiently and effectively. In one aspect, the invention is a system and/or method for processing flat articles wherein a liquid is applied to both major surfaces of the flat article. A first transducer assembly is positioned adjacent to a first of the major surfaces of the flat article and a second member is positioned adjacent to a second of the major surfaces. The first transducer assembly generates and transmits acoustical energy to the first major surface of the flat article while the second member either: (1) reflects the acoustical energy generated by the first transducer assembly back to the second major surface of the flat article; and/or (2) generates and transmits acoustical energy to the second major surface of the flat article.

摘要翻译： 用于处理具有声能的扁平制品的系统，装置和方法。 本发明的系统，装置和方法可以更有效和有效地从晶片的两侧去除颗粒。 一方面，本发明是一种用于处理扁平制品的系统和/或方法，其中将液体施加到扁平制品的两个主表面上。 第一换能器组件邻近扁平制品的第一主表面定位，并且第二构件邻近第二主表面定位。 第一换能器组件产生并将声能传递到扁平制品的第一主表面，而第二构件可以：（1）将由第一换能器组件产生的声能反射回平面物品的第二主表面; 和/或（2）产生和传播声能到平坦物品的第二主表面。

公开(公告)号：US08215859B2

公开(公告)日：2012-07-10

申请号：US13102973

申请日：2011-05-06

申请人： Jack W. Kaufman ,  James Brown

发明人： Jack W. Kaufman ,  James Brown

IPC分类号： B43K5/14

CPC分类号： A61M35/006 ,  A61M35/003 ,  A61M2210/04 ,  B43M11/06

摘要： A hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region therebetween. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose.

摘要翻译： 一种手持式分配器，其包括流体源，连接到流体源的易碎施用器尖端以及附接到易碎施用器尖端的吸收构件。 当易碎的施用器尖端破裂时，流体从源流向吸收构件，由此将流体施加并扩散在表面上。 优选地，易碎施用器尖端包括永久地连接到流体源的支撑元件，从支撑元件向外延伸的相对刚性的舌元件以及它们之间的易碎区域。 优选地，舌元件包括用于加强舌元件以防止易碎区域的无意破坏的肋。 更优选地，施用器末端包括设置在易碎区域周围的半透性或不可渗透的盖，以控制吸收构件中的流体分散体的速度和方向。 自适应实施例允许生成适用于特定医疗目的的设计。

公开(公告)号：US08099890B2

公开(公告)日：2012-01-24

申请号：US13036867

申请日：2011-02-28

申请人： Sherif Ali ,  Kim Canchola ,  Russell Smith ,  Tracy Tenpenny ,  Jeffrey Kerlin ,  Mike Erwin ,  James Brown

发明人： Sherif Ali ,  Kim Canchola ,  Russell Smith ,  Tracy Tenpenny ,  Jeffrey Kerlin ,  Mike Erwin ,  James Brown

IPC分类号： A44C5/00 ,  G09F3/14

CPC分类号： G09F3/005

摘要： A closure mechanism receiving aperture presents a substantially contiguous, uninterrupted planar surface on a flexible medium, primarily for use with identification devices, i.e., wristbands. The aperture does not interrupt the printable area so that printer ink may be printed over the aperture without passing through. The inventive aperture also does not produce waster material or chads which can jam or foul-up a printer. An inventive wristband includes both snap closure and adhesive closure mechanisms that can be used at the same time.

摘要翻译： 闭合机构接收孔在柔性介质上呈现基本连续的不间断平面，主要用于识别装置即腕带。 光圈不会打印可打印区域，因此打印机墨水可能会打印在光圈上而不通过。 本发明的孔径也不会产生可能堵塞或弄脏打印机的废物或绷带。 本发明的腕带包括可以同时使用的卡扣闭合和粘合剂封闭机构。