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公开(公告)号:US10112970B2
公开(公告)日:2018-10-30
申请号:US15402028
申请日:2017-01-09
发明人: Simon Cherniak , Rosa Cyjon , Ilana Ozer , Igor Nudelman
摘要: The present invention provides an improved process for the preparation of 17-desoxy corticosteroid derivatives in a single chemical step by reacting the 17-hydroxy starting material with an excess of Trimethylsilyl Iodide. The present invention is specifically advantageous in preparing 17-desoxy corticosteroid derivatives having one or more halogen groups at positions 2, 6, 7 or 9 of the corticosteroid such as Clocortolone of Desoximetasone.