公开(公告)号：US09724304B2

公开(公告)日：2017-08-08

申请号：US13918019

申请日：2013-06-14

Applicant: Temple University—Of The Commonwealth System of Higher Education

Inventor： Ho Lun Wong ,  Mayuri Narvekar ,  Hui Yi Xue

IPC: A61K9/16 ,  A61K31/203 ,  A61K31/405 ,  A61K9/51

CPC classification number: A61K9/16 ,  A61K9/5123 ,  A61K9/5153 ,  A61K31/203 ,  A61K31/405

Abstract: Provided is a nanosphere for delivery of a therapeutic agent comprising: a polymer matrix; discrete liquid oil droplets dispersed in the polymer matrix; and a therapeutic agent dissolved or dispersed in the oil. In some embodiments, the nanosphere is pegylated. In some embodiments, the nanosphere has a diameter of from about 100 nm to about 300 nm. In further preferred embodiments, the nanosphere has a diameter of from about 150 nm to about 250 nm. In yet further embodiments, the nanosphere has a diameter of from about 180 nm to about 220 nm. In some embodiments, the oil comprises a lipid or a phospholipid. In further embodiments, the lipid or the phospholipid has a melting point below 20° C. In some embodiments, the polymer is a natural, modified or synthetic polymer. In further embodiments, the polymer is biodegradable.

公开(公告)号：US20130337077A1

公开(公告)日：2013-12-19

申请号：US13918019

申请日：2013-06-14

Applicant: Temple University - Of The Commonwealth System of Higher Education

Inventor： Ho Lun Wong ,  Mayuri Narvekar ,  Hui Yi Xue

IPC: A61K9/16 ,  A61K31/405 ,  A61K31/203

CPC classification number: A61K9/16 ,  A61K9/5123 ,  A61K9/5153 ,  A61K31/203 ,  A61K31/405

Abstract: Provided is a nanosphere for delivery of a therapeutic agent comprising: a polymer matrix; discrete liquid oil droplets dispersed in the polymer matrix; and a therapeutic agent dissolved or dispersed in the oil. In some embodiments, the nanosphere is pegylated. In some embodiments, the nanosphere has a diameter of from about 100 nm to about 300 nm. In further preferred embodiments, the nanosphere has a diameter of from about 150 nm to about 250 nm. In yet further embodiments, the nanosphere has a diameter of from about 180 nm to about 220 nm. In some embodiments, the oil comprises a lipid or a phospholipid. In further embodiments, the lipid or the phospholipid has a melting point below 20° C. In some embodiments, the polymer is a natural, modified or synthetic polymer. In further embodiments, the polymer is biodegradable.

Abstract translation: 提供用于递送治疗剂的纳米球，包括：聚合物基质; 离散液体油滴分散在聚合物基质中; 和溶解或分散在油中的治疗剂。 在一些实施方案中，纳米球被聚乙二醇化。 在一些实施方案中，纳米球具有约100nm至约300nm的直径。 在进一步优选的实施方案中，纳米球具有约150nm至约250nm的直径。 在另外的实施方案中，纳米球具有约180nm至约220nm的直径。 在一些实施方案中，油包含脂质或磷脂。 在另外的实施方案中，脂质或磷脂具有低于20℃的熔点。在一些实施方案中，聚合物是天然的，改性的或合成的聚合物。 在另外的实施方案中，聚合物是可生物降解的。