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公开(公告)号:US20110160248A1
公开(公告)日:2011-06-30
申请号:US12975862
申请日:2010-12-22
申请人: Xianbo Zhou , Roderick E.M. Scott , Rusiko Bourtchouladze , Alan P. Kaplan , Terence P. Keenan , Andrew McRiner
发明人: Xianbo Zhou , Roderick E.M. Scott , Rusiko Bourtchouladze , Alan P. Kaplan , Terence P. Keenan , Andrew McRiner
CPC分类号: C07D409/04 , A61K31/4152 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/454 , A61K31/496 , C07D231/12 , C07D231/14 , C07D401/04 , C07D401/10 , C07D401/14 , C07D409/14 , C07D417/14 , C07D451/06 , C07D453/02 , C07D453/04 , C07D471/08
摘要: The invention provides a compound of formula I: wherein R1-R6, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of MAO-B enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
摘要翻译: 本发明提供了式I化合物:其中R1-R6,X,Y和B具有本文所述的任何值,以及这些化合物的盐,包含这些化合物的组合物,以及包括施用这样的化合物的治疗方法 化合物。 这些化合物是MAO-B酶功能的抑制剂,可用于改善认知功能和治疗动物精神疾病。
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公开(公告)号:US08927546B2
公开(公告)日:2015-01-06
申请号:US12887920
申请日:2010-09-22
申请人: Alan P. Kaplan , Terence P. Keenan , Michael I. Weinhouse , Mark E. Wilson , Andrew K. Lindstrom , William C. Ripka , Mi Chen
发明人: Alan P. Kaplan , Terence P. Keenan , Michael I. Weinhouse , Mark E. Wilson , Andrew K. Lindstrom , William C. Ripka , Mi Chen
IPC分类号: A61K31/55 , A61K31/4965 , A61K31/497 , A61K31/535 , C07D243/08 , C07D295/092 , C07D413/06 , C07D401/06 , C07D403/06 , A61K45/06 , C07D417/06 , A61K31/5377 , C07D413/14 , C07D241/04 , A61K31/496 , A61K31/495 , A61K31/551
CPC分类号: C07D403/06 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D241/04 , C07D243/08 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/06 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14 , A61K2300/00
摘要: The invention includes a compound of formula I: wherein R1, Y, A, n, R4 and Z have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of PDE4 function and are useful for improving cognitive function and/or treating cognitive disorders or impairment, traumatic and/or ischemic injuries of the central and peripheral nervous system and/or psychiatric disorders in animals, especially humans.
摘要翻译: 本发明包括式I化合物:其中R 1,Y,A,n,R 4和Z具有本文所述的任何值,以及这些化合物的盐,包含这些化合物的组合物,以及治疗方法, 这样的化合物。 这些化合物是PDE4功能的抑制剂,可用于改善认知功能和/或治疗动物,特别是人类的中枢和周围神经系统和/或精神疾病的认知障碍或损伤,创伤性和/或缺血性损伤。
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公开(公告)号:US08338405B2
公开(公告)日:2012-12-25
申请号:US12861213
申请日:2010-08-23
申请人: Terence P. Keenan , Alan P. Kaplan
发明人: Terence P. Keenan , Alan P. Kaplan
IPC分类号: A61K31/55 , A61K31/535 , A61K31/497 , A61K31/4965
CPC分类号: C07D241/06 , C07D241/04 , C07D241/08 , C07D243/08 , C07D265/30 , C07D295/096 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/08
摘要: The invention includes a compound of formula I: wherein R1, X, Z, n, and m have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of PDE4 function and are useful for improving cognitive function in animals.
摘要翻译: 本发明包括式I化合物:其中R1,X,Z,n和m具有本文所述的任何值,以及这些化合物的盐,包含这些化合物的组合物,以及包括施用此类化合物的治疗方法 化合物。 这些化合物是PDE4功能的抑制剂,可用于改善动物的认知功能。
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公开(公告)号:US08921399B2
公开(公告)日:2014-12-30
申请号:US13448052
申请日:2012-04-16
IPC分类号: A61K31/4525 , A61K31/42 , C07D413/02 , C07D261/02 , C07D261/08 , C07D413/14 , C07D487/04 , C07D413/04 , C07D453/02 , C07D491/044
CPC分类号: C07D491/044 , A61K31/4525 , A61K31/4535 , A61K31/454 , A61P25/00 , C07D261/08 , C07D413/04 , C07D413/14 , C07D453/02 , C07D487/04
摘要: The invention provides a compound of formula I: wherein A1, A2, A3, R1, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of monoamine oxidase B (MAO-B) enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
摘要翻译: 本发明提供式I化合物:其中A1,A2,A3,R1,X,Y和B具有本文所述的任何值,以及这些化合物的盐,包含这些化合物的组合物和包含 这种化合物的给药。 这些化合物是单胺氧化酶B(MAO-B)酶功能的抑制剂,可用于改善认知功能和治疗动物精神疾病。
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公开(公告)号:US08501745B2
公开(公告)日:2013-08-06
申请号:US12873452
申请日:2010-09-01
申请人: Terence P. Keenan , Alan P. Kaplan
发明人: Terence P. Keenan , Alan P. Kaplan
IPC分类号: A61K31/4965 , A61K31/497 , A61K31/495 , C07D403/02 , C07D401/02
CPC分类号: C07D241/06 , C07D241/04 , C07D241/08 , C07D243/08 , C07D265/30 , C07D295/096 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/08
摘要: The invention includes a compound of formula I: wherein R1, X, Z, n, and m have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of PDE4 function and are useful for improving cognitive function in animals.
摘要翻译: 本发明包括式I化合物:其中R1,X,Z,n和m具有本文所述的任何值,以及这些化合物的盐,包含这些化合物的组合物,以及包括施用此类化合物的治疗方法 化合物。 这些化合物是PDE4功能的抑制剂,可用于改善动物的认知功能。
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公开(公告)号:US20110065691A1
公开(公告)日:2011-03-17
申请号:US12887920
申请日:2010-09-22
申请人: Alan P. Kaplan , Terence P. Keenan , Michael I. Weinhouse , Mark E. Wilson , Andrew K. Lindstrom , William C. Ripka , Mi Chen
发明人: Alan P. Kaplan , Terence P. Keenan , Michael I. Weinhouse , Mark E. Wilson , Andrew K. Lindstrom , William C. Ripka , Mi Chen
IPC分类号: A61K31/551 , C07D241/04 , A61K31/495 , C07D403/06 , A61K31/496 , C07D413/06 , A61K31/5377 , C07D401/06 , C07D243/08 , C07D413/14 , C07D417/06 , C07D403/04 , A61P25/00 , A61P25/28 , C12N5/07
CPC分类号: C07D403/06 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D241/04 , C07D243/08 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/06 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14 , A61K2300/00
摘要: The invention includes a compound of formula I: wherein R1, Y, A, n, R4 and Z have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of PDE4 function and are useful for improving cognitive function and/or treating cognitive disorders or impairment, traumatic and/or ischemic injuries of the central and peripheral nervous system and/or psychiatric disorders in animals, especially humans.
摘要翻译: 本发明包括式I化合物:其中R 1,Y,A,n,R 4和Z具有本文所述的任何值,以及这些化合物的盐,包含这些化合物的组合物,以及治疗方法, 这样的化合物。 这些化合物是PDE4功能的抑制剂,可用于改善认知功能和/或治疗动物,特别是人类的中枢和周围神经系统和/或精神疾病的认知障碍或损伤,创伤性和/或缺血性损伤。
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公开(公告)号:US20100317648A1
公开(公告)日:2010-12-16
申请号:US12849418
申请日:2010-08-03
申请人: Xianbo Zhou , Roderick E. M. Scott , Rusiko Bourtchouladze , Alan P. Kaplan , Terence P. Keenan , Andrew McRiner
发明人: Xianbo Zhou , Roderick E. M. Scott , Rusiko Bourtchouladze , Alan P. Kaplan , Terence P. Keenan , Andrew McRiner
IPC分类号: A61K31/397 , A61K31/55 , A61K31/5377 , A61K31/496 , A61K31/4439 , A61K31/4155 , C07D413/14 , C07D409/14 , C07D409/04 , A61P25/28 , A61P25/00 , A61P25/16
CPC分类号: C07D409/04 , A61K31/4152 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/454 , A61K31/496 , C07D231/12 , C07D231/14 , C07D401/04 , C07D401/10 , C07D401/14 , C07D409/14 , C07D417/14 , C07D451/06 , C07D453/02 , C07D453/04 , C07D471/08
摘要: The invention provides a compound of formula I: wherein R1-R6, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of MAO-B enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
摘要翻译: 本发明提供了式I化合物:其中R1-R6,X,Y和B具有本文所述的任何值,以及这些化合物的盐,包含这些化合物的组合物,以及包括施用这样的化合物的治疗方法 化合物。 这些化合物是MAO-B酶功能的抑制剂,可用于改善认知功能和治疗动物精神疾病。
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公开(公告)号:US20090062252A1
公开(公告)日:2009-03-05
申请号:US12198686
申请日:2008-08-26
IPC分类号: A61K31/422 , C07D413/04 , A61K31/454 , C07D413/14 , A61P25/28
CPC分类号: C07D491/044 , A61K31/4525 , A61K31/4535 , A61K31/454 , A61P25/00 , C07D261/08 , C07D413/04 , C07D413/14 , C07D453/02 , C07D487/04
摘要: The invention provides a compound of formula I: wherein A1, A2, A3, R1, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of monoamine oxidase B (MAO-B) enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
摘要翻译: 本发明提供式I化合物:其中A1,A2,A3,R1,X,Y和B具有本文所述的任何值,以及这些化合物的盐,包含这些化合物的组合物和包含 这种化合物的给药。 这些化合物是单胺氧化酶B(MAO-B)酶功能的抑制剂,可用于改善认知功能和治疗动物精神疾病。
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公开(公告)号:US09029397B2
公开(公告)日:2015-05-12
申请号:US13542358
申请日:2012-07-05
IPC分类号: A61K31/4525 , A61K31/4535 , A61K31/454 , C07D261/08 , C07D413/04 , C07D413/14 , C07D453/02 , C07D487/04 , C07D491/044
CPC分类号: C07D491/044 , A61K31/4525 , A61K31/4535 , A61K31/454 , A61P25/00 , C07D261/08 , C07D413/04 , C07D413/14 , C07D453/02 , C07D487/04
摘要: The invention provides a compound of formula I: wherein A1, A2, A3, R1, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of monoamine oxidase B (MAO-B) enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
摘要翻译: 本发明提供式I化合物:其中A1,A2,A3,R1,X,Y和B具有本文所述的任何值,以及这些化合物的盐,包含这些化合物的组合物和包含 这种化合物的给药。 这些化合物是单胺氧化酶B(MAO-B)酶功能的抑制剂,可用于改善认知功能和治疗动物精神疾病。
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公开(公告)号:US08399487B2
公开(公告)日:2013-03-19
申请号:US12975862
申请日:2010-12-22
申请人: Xianbo Zhou , Roderick E. M. Scott , Rusiko Bourtchouladze , Alan P. Kaplan , Terence P. Keenan , Andrew McRiner
发明人: Xianbo Zhou , Roderick E. M. Scott , Rusiko Bourtchouladze , Alan P. Kaplan , Terence P. Keenan , Andrew McRiner
IPC分类号: A61K31/445
CPC分类号: C07D409/04 , A61K31/4152 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/454 , A61K31/496 , C07D231/12 , C07D231/14 , C07D401/04 , C07D401/10 , C07D401/14 , C07D409/14 , C07D417/14 , C07D451/06 , C07D453/02 , C07D453/04 , C07D471/08
摘要: The invention provides a compound of formula I: wherein R1-R6, X, Y, and B have any of the values described herein, as well as salts of such compounds, compositions comprising such compounds, and therapeutic methods that comprise the administration of such compounds. The compounds are inhibitors of MAO-B enzyme function and are useful for improving cognitive function and for treating psychiatric disorders in animals.
摘要翻译: 本发明提供了式I化合物:其中R1-R6,X,Y和B具有本文所述的任何值,以及这些化合物的盐,包含这些化合物的组合物,以及包括施用这样的化合物的治疗方法 化合物。 这些化合物是MAO-B酶功能的抑制剂,可用于改善认知功能和治疗动物精神疾病。
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