公开(公告)号：US06576656B1

公开(公告)日：2003-06-10

申请号：US09763241

申请日：2001-03-22

申请人： Teruhisa Tokunaga ,  Takashi Umezome ,  W. Ewan Hume ,  Ryu Nagata ,  Kazuhiko Okazaki ,  Yasuyuki Ueki ,  Kazuo Kumagai

发明人： Teruhisa Tokunaga ,  Takashi Umezome ,  W. Ewan Hume ,  Ryu Nagata ,  Kazuhiko Okazaki ,  Yasuyuki Ueki ,  Kazuo Kumagai

IPC分类号： A61K3140

CPC分类号： C07D401/04 ,  C07D209/38 ,  C07D209/40 ,  C07D403/06 ,  C07D405/04 ,  C07D409/04 ,  C07D413/06 ,  C07D417/04

摘要： An oxindole of Formula 1 or a prodrug thereof, or a pharmaceutically acceptable salt thereof is useful for growth hormone releaser: wherein R1, R2, R3 and R4 are independently hydrogen, optionally substituted alkyl etc; R5 is optionally substituted aryl or optionally substituted heteroaryl; Z is —O— or —NH—; one of W1 and W2 is hydrogen, alkyl or —Y—CON(R10)R11; the other of W1 and W2 is n is 1, 2 or 3; m is 0, 1, 2 or 3; Y is single bond or C1-C3 alkylene; R6 and R7 are independently hydrogen, optionally substituted alkyl etc; R8 and R9 are independently hydrogen, optionally substituted alkyl etc; R10 and R11 are independently hydrogen, alkyl etc.

摘要翻译： 式1的羟吲哚或其前药或其药学上可接受的盐可用于生长激素释放剂：其中R 1，R 2，R 3和R 4独立地为氢，任选取代的烷基等; R 5为任选取代的芳基或任选取代的杂芳基; Z 是-O-或-NH-; W1和W2之一是氢，烷基或-Y-CON（R10）R11; W1和W2中的另一个是1,2或3; m是0,1,2或3; Y是单键或C1-C3亚烷基; R6和R7独立地是氢，任选取代的烷基等; R 8和R 9独立地是氢，任选取代的烷基等; R 10和R 11独立地是氢 ，烷基等

公开(公告)号：US20060063762A1

公开(公告)日：2006-03-23

申请号：US10517446

申请日：2003-06-10

申请人： Yoshihide Ueno ,  Tsuyoshi Noguchi ,  Kotara Hirota ,  Nobuyuki Sawada ,  Takashi Umezome

发明人： Yoshihide Ueno ,  Tsuyoshi Noguchi ,  Kotara Hirota ,  Nobuyuki Sawada ,  Takashi Umezome

IPC分类号： A61K31/538 ,  A61K31/427 ,  A61K31/422 ,  A61K31/428 ,  A61K31/423

CPC分类号： C07D209/14 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D498/04

摘要： The compound of the formula (I): wherein W is a group of the following formula (VIII) binding to any possible position on the Q: Q is, together with W, a group of the formula: —C(W)═C(R3A)—N(R3)—, etc.; R3A is H or optionally substituted lower alkyl; R4, R5, R6, and R7 are independently H or optionally substituted lower alkyl; R1 is optionally substituted lower alkyl, etc.; R2 is H, etc.; R3 is H, etc.; Ar is phenyl, etc., or a pharmaceutically acceptable salt thereof, where these compounds exhibiting β3-adrenoceptor-stimulating activity and being useful as a medicament for treatment of obesity, etc.

摘要翻译： 式（I）的化合物：

公开(公告)号：US07217724B2

公开(公告)日：2007-05-15

申请号：US10517446

申请日：2003-06-10

申请人： Yoshihide Ueno ,  Tsuyoshi Noguchi ,  Kotaro Hirota ,  Nobuyuki Sawada ,  Takashi Umezome

发明人： Yoshihide Ueno ,  Tsuyoshi Noguchi ,  Kotaro Hirota ,  Nobuyuki Sawada ,  Takashi Umezome

IPC分类号： A61K31/4439 ,  C07D401/06

CPC分类号： C07D209/14 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D498/04

摘要： The compound of the formula (I): wherein W is a group of the following formula (VIII) binding to any possible position on the Q: Q is, together with W, a group of the formula: —C(W)═C(R3A)—N(R3)—, etc.; R3A is H or optionally substituted lower alkyl; R4, R5, R6, and R7 are independently H or optionally substituted lower alkyl; R1 is optionally substituted lower alkyl, etc.; R2 is H, etc.; R3 is H, etc.; Ar is phenyl, etc., or a pharmaceutically acceptable salt thereof, where these compounds exhibiting β3-adrenoceptor-stimulating activity and being useful as a medicament for treatment of obesity, etc.

摘要翻译： 式（I）的化合物：其中W是结合Q：Q上的任何可能位置的下式（VIII）的基团与W一起为下式-C（W）-C （R 3）N（R 3） - 等; R 3是H或任选取代的低级烷基; R 4，R 5，R 6和R 7独立地是H或任选取代的低级烷基; R 1是任选取代的低级烷基等; R 2是H等; R 3是H等; Ar是苯基等，或其药学上可接受的盐，其中这些具有β3肾上腺素能受体刺激活性的化合物可用作治疗肥胖症的药物等。