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公开(公告)号:US20050227978A1
公开(公告)日:2005-10-13
申请号:US10502933
申请日:2003-01-28
申请人: Teruhisa Tokunaga , Willian Hume , Makoto Kitoh , Ryu Nagata , Michiko Kishino , Tsutomu Nakagawa , Jun Nagamine , Mutsuo Taiji
发明人: Teruhisa Tokunaga , Willian Hume , Makoto Kitoh , Ryu Nagata , Michiko Kishino , Tsutomu Nakagawa , Jun Nagamine , Mutsuo Taiji
IPC分类号: A61K31/381 , A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4155 , A61K31/4174 , A61K31/425 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/498 , A61K31/4985 , A61K31/5377 , A61P11/00 , A61P13/12 , A61P17/00 , A61P43/00 , C07D207/32 , C07D207/333 , C07D233/64 , C07D401/06 , A61K31/401 , A61K31/4164
CPC分类号: C07D207/333 , A61K31/381 , A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4155 , A61K31/4174 , A61K31/425 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/4709 , A61K31/496 , A61K31/498 , A61K31/4985 , A61K31/5377 , C07D401/06
摘要: Medicament being useful as a fibrosis inhibitor for organs or tissues, which comprises a compound of the formula (I): wherein Ring Z is optionally substituted pyrrole ring, etc.; W2 is —CO—, —SO2—, optionally substituted C1-C4 alkylene, etc.; Ar2 is optionally substituted aryl, etc.; W1 and Ar1 mean the following (1) and (2): (1) W1 is optionally substituted C1-C4 alkylene, etc.; Ar1 is optionally substituted bicyclic heteroaryl having 1 to 4 nitrogen atoms as ring-forming atoms: (2) W1 is optionally substituted C2-C5 alkylene, optionally substituted C2-C5 alkenylene, etc.; and Ar1 is aryl or monocyclic heteroaryl, which is substituted by carboxyl, alkoxycarbonyl, etc. at the ortho- or meta-position thereof with respect to the binding position of W1, or a pharmaceutically acceptable salt thereof.
摘要翻译: 药物用作器官或组织的纤维化抑制剂,其包含式(I)的化合物:其中环Z是任选取代的吡咯环等; W 2是-CO - , - SO 2 - ,任选取代的C 1 -C 4亚烷基等 。 Ar 2是任选取代的芳基等; (1)和(2):(1)W 1是任选取代的C 1 亚烷基等; 任选取代的具有1至4个氮原子的双环杂芳基作为成环原子:(2)W 1是任选取代的C 2 - -C 5亚烷基,任选取代的C 2 -C 5亚烯基等; 和Ar 1是在相邻或相对于W 1的结合位置的邻位或间位被羧基,烷氧基羰基等取代的芳基或单环杂芳基 >,或其药学上可接受的盐。