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公开(公告)号:US20210008111A1
公开(公告)日:2021-01-14
申请号:US16924950
申请日:2020-07-09
发明人: Amara Seng , Ryan Fischer , Thomas Yankee , Mary Markiewicz , John Szarejko
IPC分类号: A61K35/17 , C12N15/86 , C12N5/0783
摘要: Cell therapy compositions comprising engineered human regulatory T cells (eTregs) characterized by ectopic overexpression of FOXP3 and Helios protein, produced via introduction of separate nucleic acid constructs respectively encoding FOXP3 and Helios (FOXP3+Helios+eTregs). Cell therapy compositions comprising mixed populations of CD4+ and CD8+ Treg cells each with ectopic overexpression of FOXP3 and Helios. Methods of making and use the same for therapies involving inflammation and/or a disorder of the immune system.
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公开(公告)号:US20220008474A1
公开(公告)日:2022-01-13
申请号:US17488702
申请日:2021-09-29
发明人: Amara Seng , Ryan Fischer , Thomas Yankee , Mary Markiewicz , John Szarejko
IPC分类号: A61K35/17 , C12N15/86 , C12N5/0783
摘要: Cell therapy compositions comprising engineered human regulatory T cells (eTregs) characterized by ectopic overexpression of FOXP3 and Helios protein, produced via introduction of separate nucleic acid constructs respectively encoding FOXP3 and Helios (FOXP3+ Helios+ eTregs). Cell therapy compositions comprising mixed populations of CD4+ and CD8+ Treg cells each with ectopic overexpression of FOXP3 and Helios. Methods of making and use the same for therapies involving inflammation and/or a disorder of the immune system.
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公开(公告)号:US11160832B2
公开(公告)日:2021-11-02
申请号:US16924950
申请日:2020-07-09
发明人: Amara Seng , Ryan Fischer , Thomas Yankee , Mary Markiewicz , John Szarejko
IPC分类号: C12N5/00 , A61K35/17 , C12N15/86 , C12N5/0783
摘要: Cell therapy compositions comprising engineered human regulatory T cells (eTregs) characterized by ectopic overexpression of FOXP3 and Helios protein, produced via introduction of separate nucleic acid constructs respectively encoding FOXP3 and Helios (FOXP3+Helios+eTregs). Cell therapy compositions comprising mixed populations of CD4+ and CD8+ Treg cells each with ectopic overexpression of FOXP3 and Helios. Methods of making and use the same for therapies involving inflammation and/or a disorder of the immune system.
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