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公开(公告)号：US20230293000A1
公开(公告)日：2023-09-21
申请号：US18099480
申请日：2023-01-20
Applicant: The George Washington University , 460Medical, Inc.
Inventor： Omar Amirana , Kenneth C. Armstrong , Matthew W. Kay , Marco A. Mercader , Terrance J. Ransbury , Narine Sarvazyan
IPC: A61B1/04 , A61B5/00 , A61B5/1459 , A61B18/00 , A61B1/00 , A61B1/06 , A61B5/145 , A61B90/35 , A61B1/05 , A61B90/30 , A61B90/00 , A61B18/14
CPC classification number: A61B1/043 , A61B5/0044 , A61B5/1459 , A61B5/6853 , A61B18/00 , A61B1/00082 , A61B1/0638 , A61B5/14546 , A61B1/00045 , A61B5/14503 , A61B90/35 , A61B1/00186 , A61B1/05 , A61B1/0676 , A61B1/0684 , A61B5/0084 , A61B5/004 , A61B90/30 , A61B90/361 , A61B1/00009 , A61B18/1492 , A61B2034/301
Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter having a distal end and a proximal end; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon, the optical housing being configured to position inside the balloon a light source for illuminating a tissue outside the balloon and a camera for imaging the illuminated tissue.
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公开(公告)号：US11559352B2
公开(公告)日：2023-01-24
申请号：US16879956
申请日：2020-05-21
Applicant: The George Washington University , 460Medical, Inc.
Inventor： Omar Amirana , Kenneth C. Armstrong , James Bowen , Cinnamon Larson , Marco A. Mercader , Terrance J. Ransbury , Narine Sarvazyan
Abstract: Ablation visualization and monitoring systems and methods are provided. In some embodiments, such methods comprise applying ablation energy to a tissue to form a lesion in the tissue, illuminating the tissue with a light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both, monitoring a level of NADH fluorescence in the illuminated tissue to determine when the level of NADH fluorescence decreases from a base level in the beginning of the ablating to a predetermined lower level, and stopping ablation of the tissue when the level of NADH fluorescence reaches the predetermined lower level.
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公开(公告)号：US11559192B2
公开(公告)日：2023-01-24
申请号：US16879929
申请日：2020-05-21
Applicant: The George Washington University , 460Medical, Inc.
Inventor： Omar Amirana , Kenneth C. Armstrong , Matthew W. Kay , Marco A. Mercader , Terrance J. Ransbury , Narine Sarvazyan
IPC: A61B1/04 , A61B5/00 , A61B5/1459 , A61B18/00 , A61B1/00 , A61B1/06 , A61B5/145 , A61B90/35 , A61B1/05 , A61B90/30 , A61B90/00 , A61B18/14 , A61B34/30 , A61B18/02
Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter having a distal end and a proximal end; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon, the optical housing being configured to position inside the balloon a light source for illuminating a tissue outside the balloon and a camera for imaging the illuminated tissue.
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公开(公告)号：US12075980B2
公开(公告)日：2024-09-03
申请号：US18099480
申请日：2023-01-20
Applicant: The George Washington University , 460Medical, Inc.
Inventor： Omar Amirana , Kenneth C. Armstrong , Matthew W. Kay , Marco A. Mercader , Terrance J. Ransbury , Narine Sarvazyan
IPC: A61B1/04 , A61B1/00 , A61B1/05 , A61B1/06 , A61B5/00 , A61B5/145 , A61B5/1459 , A61B18/00 , A61B18/14 , A61B90/00 , A61B90/30 , A61B90/35 , A61B18/02 , A61B34/30
CPC classification number: A61B1/043 , A61B1/00009 , A61B1/00045 , A61B1/00082 , A61B1/00186 , A61B1/05 , A61B1/0638 , A61B1/0676 , A61B1/0684 , A61B5/004 , A61B5/0044 , A61B5/0084 , A61B5/14503 , A61B5/14546 , A61B5/1459 , A61B5/6853 , A61B18/00 , A61B18/1492 , A61B90/30 , A61B90/35 , A61B90/361 , A61B2018/0022 , A61B2018/0212 , A61B2034/301 , A61B2090/365 , Y02A90/10
Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter having a distal end and a proximal end; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon, the optical housing being configured to position inside the balloon a light source for illuminating a tissue outside the balloon and a camera for imaging the illuminated tissue.
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公开(公告)号：US20220142482A1
公开(公告)日：2022-05-12
申请号：US17388312
申请日：2021-07-29
Applicant: The George Washington University , 460Medical, Inc.
Inventor： Marco A. Mercader , Narine Sarvazyan , Terrance J. Ransbury , Kenneth C. Armstrong , Omar Amirana
Abstract: Systems, catheter and methods for treating Atrial Fibrillation (AF) are provided, which are configure to illuminate a heart tissue having a lesion site; obtain a mitochondrial nicotinamide adenine dinucleotide hydrogen (NADH) fluorescence intensity from the illuminated heart tissue along a first line across the lesion site; create a 2-dimensional (2D) map of the depth of the lesion site along the first line based on the NADH fluorescence intensity; and determine a depth of the lesion site at a selected point along the first line from the 2D map, wherein a lower NADH fluorescence intensity corresponds to a greater depth in the lesion site and a higher NADH fluorescence intensity corresponds to an unablated tissue. The process may be repeated to create a 3 dimensional map of the depth of the lesion.
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公开(公告)号：US11096584B2
公开(公告)日：2021-08-24
申请号：US14541991
申请日：2014-11-14
Applicant: The George Washington University , 460MEDICAL, INC.
Inventor： Marco A. Mercader , Narine Sarvazyan , Terrance J. Ransbury , Kenneth C. Armstrong , Omar Amirana
Abstract: Systems, catheter and methods for treating Atrial Fibrillation (AF) are provided, which are configure to illuminate a heart tissue having a lesion site; obtain a mitochondrial nicotinamide adenine dinucleotide hydrogen (NADH) fluorescence intensity from the illuminated heart tissue along a first line across the lesion site; create a 2-dimensional (2D) map of the depth of the lesion site along the first line based on the NADH fluorescence intensity; and determine a depth of the lesion site at a selected point along the first line from the 2D map, wherein a lower NADH fluorescence intensity corresponds to a greater depth in the lesion site and a higher NADH fluorescence intensity corresponds to an unablated tissue. The process may be repeated to create a 3 dimensional map of the depth of the lesion.
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公开(公告)号：US10716462B2
公开(公告)日：2020-07-21
申请号：US15986970
申请日：2018-05-23
Applicant: The George Washington University , 460MEDICAL, INC.
Inventor： Omar Amirana , Kenneth C. Armstrong , Matthew W. Kay , Marco A. Mercader , Terrance J. Ransbury , Narine Sarvazyan
IPC: A61B1/04 , A61B5/00 , A61B5/1459 , A61B18/00 , A61B1/00 , A61B1/06 , A61B5/145 , A61B90/35 , A61B1/05 , A61B90/30 , A61B90/00 , A61B18/14 , A61B34/30 , A61B18/02
Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter having a distal end and a proximal end; an inflatable balloon disposed about the distal end of the catheter; and an optical housing extending from the distal end of the catheter into the balloon, the optical housing being configured to position inside the balloon a light source for illuminating a tissue outside the balloon and a camera for imaging the illuminated tissue.
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公开(公告)号：US20160120599A1
公开(公告)日：2016-05-05
申请号：US14931262
申请日：2015-11-03
Applicant: The George Washington University , LuxCath, LLC
Inventor： Omar Amirana , Kenneth C. Armstrong , James Bowen , Cinnamon Larson , Marco A. Mercader , Terrance J. Ransbury , Narine Sarvazyan
Abstract: Ablation visualization and monitoring systems and methods are provided. In some embodiments, such methods comprise applying ablation energy to a tissue to form a lesion in the tissue, illuminating the tissue with a light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both, monitoring a level of NADH fluorescence in the illuminated tissue to determine when the level of NADH fluorescence decreases from a base level in the beginning of the ablating to a predetermined lower level, and stopping ablation of the tissue when the level of NADH fluorescence reaches the predetermined lower level.
Abstract translation: 提供消融可视化和监测系统和方法。 在一些实施例中，这样的方法包括将组织消融能量施加到组织中形成病变，用光照射组织以激发组织中的NADH，其中组织在径向，轴向或两者上照射 监测照射组织中的NADH荧光水平，以确定NADH荧光的水平何时从消融开始至基本水平降低至预定的较低水平，并且当NADH荧光水平达到 预定较低水平。
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公开(公告)号：US20130102862A1
公开(公告)日：2013-04-25
申请号：US13624899
申请日：2012-09-22
Applicant: THE GEORGE WASHINGTON UNIVERSITY
Inventor： Marco A. Mercader , Matthew W. Kay , Narine Sarvazyan
CPC classification number: A61B5/0071 , A61B1/00045 , A61B1/00082 , A61B1/00165 , A61B1/00186 , A61B1/042 , A61B1/043 , A61B1/05 , A61B1/06 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B1/0676 , A61B1/0684 , A61B5/0084 , A61B5/14546 , A61B5/1459 , A61B5/4848 , A61B5/6853 , A61B5/742 , A61B18/00 , A61B18/02 , A61B18/1492 , A61B2018/00357 , A61B2018/00577 , A61B2018/00982
Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue includes a catheter having an expandable balloon at a distal end, an illumination device positioned within the balloon for propagating light from an external light source for illuminating a tissue being treated to excite native nicotinamide adenine dinucleotide hydrogen (NADH) in the tissue, and an imaging device positioned within the balloon for detecting fluorescence from the illuminated tissue, the imaging device being configured to communicate detected NADH fluorescence to an external fluorescence camera.
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公开(公告)号：US10736512B2
公开(公告)日：2020-08-11
申请号：US14622477
申请日：2015-02-13
Applicant: The George Washington University
Inventor： Marco A. Mercader , Matthew W. Kay , Narine Sarvazyan
IPC: A61B5/00 , A61B5/1459 , A61B5/145 , A61B18/00 , A61B1/04 , A61B1/06 , A61B1/00 , A61B1/05 , A61B18/14 , A61B18/02
Abstract: Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue includes a catheter having an expandable balloon at a distal end, an illumination device positioned within the balloon for propagating light from an external light source for illuminating a tissue being treated to excite native nicotinamide adenine dinucleotide hydrogen (NADH) in the tissue, and an imaging device positioned within the balloon for detecting fluorescence from the illuminated tissue, the imaging device being configured to communicate detected NADH fluorescence to an external fluorescence camera.
