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公开(公告)号:US20220226335A1
公开(公告)日:2022-07-21
申请号:US17605194
申请日:2020-04-23
发明人: Jack Jhamandas , Wen Fu , Ryoichi Kimura , D. Lorne Tyrrell , Ana Clementin , Kamlesh Sahu , Alexandr Belovodskiy , Mostofa Hena , Bing Bai , Appan Srinivas Kandadai , James A. Nieman , Michael Houghton
IPC分类号: A61K31/538 , A61K31/513 , A61K31/5377 , A61K31/5513 , A61P25/28
摘要: The present disclosure provides non-peptidic heterocycle-containing amylin receptor antagonist compounds, compositions that include the subject compounds, methods for preparing and using the amylin receptor antagonists, and compositions containing the amylin receptor antagonists for treating, preventing, or ameliorating Alzheimer's disease. Aspects of the present disclosure include a method of inhibiting activity of an amylin receptor by administering to a subject in need thereof a therapeutically effective amount of an amylin receptor antagonist.
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公开(公告)号:US20230136702A1
公开(公告)日:2023-05-04
申请号:US17800516
申请日:2021-03-02
IPC分类号: A61K31/4985 , C07D471/04 , C07D519/00 , A61K31/4375 , A61K31/522 , A61K31/662 , A61K31/517 , A61P31/22
摘要: Provided herein are compounds, compositions and methods for inhibition of herpesviruses. In some cases, the subject compounds inhibit a herpesvirus in a cell. Also provided are compounds, compositions and methods for treating a herpesvirus in an individual. In some cases, the methods include administering to an individual a therapeutically effective amount of a subject compound to treat the individual for the herpesvirus. In certain embodiments, the compounds disclosed herein are cytomegalovirus (CMV) inhibitors. In certain embodiments, the compounds disclosed herein are human cytomegalovirus (CMV) inhibitors.
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公开(公告)号:US20220204476A1
公开(公告)日:2022-06-30
申请号:US17556700
申请日:2021-12-20
发明人: James A. Nieman , M. Joanne Lemieux , D. Lorne Tyrrell , Bing Bai , Alexandr Belovodskiy , Mostofa Hena , Appan Srinivas Kandadai , Michael A. Joyce
IPC分类号: C07D401/14 , C07D401/12 , C07D409/12 , C07D409/14 , C07D471/04 , C07D405/12 , C07D405/14 , C07D211/76 , C07D513/04 , C07D413/12 , A61P31/14
摘要: The present disclosure provides compounds and methods for inhibiting a virus infection, such as a Baltimore Group IV RNA virus infection, such as rhinovirus, coxsackievirus, norovirus and coronavirus. Aspects of the present disclosure also include methods of treating a virus infection in a subject.
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公开(公告)号:US20220119356A1
公开(公告)日:2022-04-21
申请号:US17505250
申请日:2021-10-19
发明人: James A. Nieman , Jack Jhamandas , Bing Bai , Alexandr Belovodskiy , Wen Fu , Mostofa Hena , Michael Houghton , Appan Srinivas Kandadai , Ryoichi Kimura , Kamlesh Kumar Sahu , D. Lorne Tyrrell
IPC分类号: C07D243/12 , C07D243/14 , C07D403/12 , C07D241/44 , A61P25/28
摘要: The present disclosure provides compounds that are amylin receptor antagonist compounds, compositions that include the subject compounds, methods for preparing and using the amylin receptor antagonists, and compositions containing the amylin receptor antagonists for treating, preventing, or ameliorating Alzheimer's disease. Aspects of the present disclosure include a method of inhibiting activity of an amylin receptor by administering to a subject in need thereof a therapeutically effective amount of an amylin receptor antagonist.
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