公开(公告)号：US20210059942A1

公开(公告)日：2021-03-04

申请号：US17096268

申请日：2020-11-12

申请人： The Methodist Hospital Research Institute

发明人： Haifa Shen ,  Mauro Ferrari ,  Xiaoyong Deng ,  Guodong Zhang

IPC分类号： A61K9/14 ,  A61K47/64

摘要： The present disclosure is directed to a composition for the sustained-release delivery of an active agent to a target cell of an individual. The compositions disclosed herein comprise of at least one porous particle; at least one polymer; and at least one active agent. In an embodiment, the porous particle comprises a plurality of microscale reservoirs. In an exemplary embodiment, the at least one active agent is covalently linked to the at least one polymer to form a polymer-active agent conjugate, and the polymer-active agent conjugate is contained in the plurality of microscale reservoirs of the porous particle. In some embodiments, the active agent is released with zero-order or near zero-order kinetics following administration of the composition. The present disclosure is also directed to a method of treating a tumor by administering to an individual the composition described supra.