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1.发明授权
公开(公告)号：US5070071A
公开(公告)日：1991-12-03
申请号：US255792
申请日：1988-10-11
IPC分类号： C04B35/45 , C04B35/653 , C23C2/04 , H01L39/24
CPC分类号： H01L39/248 , C04B35/4521 , C04B35/653 , C23C2/04 , Y10S505/704 , Y10S505/733 , Y10S505/74
摘要： A method is provided for making a flexible superconductive composite wire by drawing a wire of noble metal through a melt formed from solid superconducting material. The preferred superconducting material comprises the Bi-Sr-Ca-Cu-O class of materials.
摘要翻译： 提供了一种用于通过由固体超导材料形成的熔体拉伸贵金属丝来制造柔性超导复合材料线的方法。 优选的超导材料包括Bi-Sr-Ca-Cu-O类材料。
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公开(公告)号：US5122504A
公开(公告)日：1992-06-16
申请号：US486042
申请日：1990-02-27
申请人： Dan Gazit , Robert S. Feigelson
发明人： Dan Gazit , Robert S. Feigelson
CPC分类号： C30B29/225 , C30B15/007 , Y10S505/729 , Y10S505/739 , Y10S505/74
摘要： A method of growing a superconducting ribbon from a molten region of a Bi-based superconducting source material using two parallel platinum support wires is described. A method of annealing the ribbon in air to reduce the quantity of nonsuperconducting phases is also described.
摘要翻译： 描述了使用两个平行的铂支撑线从Bi基超导源材料的熔融区域生长超导带的方法。 还描述了在空气中退火带以减少非超导相的量的方法。
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3.发明授权Methods of implanting mesenchymal stem cells for tissue repair and formation 有权植入间充质干细胞用于组织修复和形成的方法公开(公告)号：US08142773B2
公开(公告)日：2012-03-27
申请号：US12007954
申请日：2008-01-17
申请人： Hadi Aslan , Dan Gazit , Zulma Gazit
发明人： Hadi Aslan , Dan Gazit , Zulma Gazit
IPC分类号： A61K48/00
CPC分类号： C07K16/2842 , A61K35/28 , A61K2035/124 , C07K16/2884 , C07K16/289 , C07K16/2896 , C12N5/0663
摘要： The invention relates to methods of isolating and implanting mesenchymal stem cells for tissue repair or formation, without prior culture expansion of the mesenchymal stem cells. In particular, the invention relates to methods of isolating mesenchymal stem cells from bone marrow, for repairing or inducing formation of bone, without prior culture expansion of the mesenchymal stem cells. The invention further relates to an isolated, non-culturally expanded human adult mesenchymal stem cell population.
摘要翻译： 本发明涉及分离和植入间充质干细胞用于组织修复或形成的方法，而不需要间充质干细胞的先前培养扩增。 特别地，本发明涉及从骨髓中分离间充质干细胞，用于修复或诱导骨形成，而不需要间充质干细胞的先前培养扩增的方法。 本发明还涉及分离的非文化扩展的人成人间充质干细胞群体。
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公开(公告)号：US20050271637A1
公开(公告)日：2005-12-08
申请号：US10642503
申请日：2003-08-18
申请人： Peter Van Bodine , Dan Gazit
发明人： Peter Van Bodine , Dan Gazit
IPC分类号： A61K48/00 , A61P19/08 , C07H21/04 , C07K14/51 , C12N5/08 , C12N15/63 , C12N15/85 , C12N15/86 , C12Q1/68
CPC分类号： C12Q1/6897 , A61K48/00 , C07H21/04 , C07K14/51 , C12N15/85 , C12N2830/001 , C12N2830/008 , C12N2830/85
摘要： The invention relates to an isolated nucleic acid corresponding to BMP-2 regulatory region, or a fragment thereof comprising an estrogen responsive element, vector comprising the same and cells, which comprises said vector. In another embodiment, the invention provides methods of identifying an estrogen agonist, antagonist and a therapeutic agent in another embodiment the invention provides methods of treating conditions which are associated with estrogen insufficiency or with lack of response to external estrogen or agonists thereof.
摘要翻译： 本发明涉及对应于BMP-2调节区的分离的核酸，或其包含雌激素反应元件的片段，其包含其的载体和包含所述载体的细胞。 在另一个实施方案中，本发明提供鉴定雌激素激动剂，拮抗剂和治疗剂的方法，在另一个实施方案中，本发明提供治疗与雌激素不足或与外部雌激素或其激动剂不具有反应相关的病症的方法。
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5.发明授权Composite scaffolds and methods using same for generating complex tissue grafts 有权复合支架和使用它们的方法产生复杂的组织移植物公开(公告)号：US08197553B2
公开(公告)日：2012-06-12
申请号：US12285107
申请日：2008-09-29
申请人： Dan Gazit , Abraham J. Domb , Gadi Turgeman , Gadi Pelled , Tony Azzam
发明人： Dan Gazit , Abraham J. Domb , Gadi Turgeman , Gadi Pelled , Tony Azzam
IPC分类号： A61F2/02
CPC分类号： A61L27/3604 , A61L27/18 , A61L27/20 , A61L27/22 , A61L27/3625 , A61L27/38 , A61L27/3839 , A61L27/3886 , A61L27/3891 , A61L27/3895 , A61L27/40 , A61L27/48 , A61L27/507 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2300/604 , A61L2430/36 , C12M25/14 , C12N5/0068 , C12N5/0662 , C12N2501/155 , C12N2502/28 , C12N2510/00 , C12N2533/40 , C12N2533/54 , C12N2533/70 , C12N2533/72 , C08L67/04 , C08L71/02
摘要： A composite scaffold for engineering a heterogeneous tissue is provided. The composite scaffold includes: (a) a first scaffold being capable of supporting formation of a first tissue type thereupon; and (b) a second scaffold being capable of supporting formation of a second tissue type thereupon; wherein the first scaffold and the second scaffold are arranged with respect to each other such that when the first scaffold supports the first tissue type and the second scaffold supports the second tissue type, a distance between any cell of the second tissue type and the first tissue type does not exceed 200 μm.
摘要翻译： 提供了一种用于工程异质组织的复合支架。 所述复合支架包括：（a）第一支架能够支撑其上形成第一组织类型; 和（b）第二支架能够支持其上形成第二组织类型; 其中所述第一支架和所述第二支架相对于彼此布置，使得当所述第一支架支撑所述第一组织类型并且所述第二支架支撑所述第二组织型时，所述第二组织类型的任何细胞与所述第一组织之间的距离 类型不超过200μm。
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6.发明申请公开(公告)号：US20110217730A1
公开(公告)日：2011-09-08
申请号：US13108038
申请日：2011-05-16
申请人： Dan Gazit , Boris Rubinsky , Gadi Pelled , Zulma Gazit
发明人： Dan Gazit , Boris Rubinsky , Gadi Pelled , Zulma Gazit
CPC分类号： C12Q1/04 , G01N15/1031 , G01N27/745 , G01N2015/1006 , G01N2015/1081
摘要： A system for qualifying cells of a cell sample labeled with a magnetic or magnetizable moiety is provided. The system includes a cell sample holder for holding a cell of the cells and a first cell analyzer which includes a magnetic field source for applying a magnetic field to the cell and a sensor for qualifying and/or quantifying an effect of the magnetic field on the cell.
摘要翻译： 提供了用磁性或可磁化部分标记的细胞样品的细胞鉴定系统。 该系统包括用于保持单元的单元的单元样本保持器和包括用于向单元施加磁场的磁场源的第一单元分析器和用于限定和/或量化磁场对磁场的影响的传感器 细胞。
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公开(公告)号：US20100209400A1
公开(公告)日：2010-08-19
申请号：US12627034
申请日：2009-11-30
申请人： Dan Gazit , Gadi Pelled , Gadi Turgeman , Andrea Hoffmann , Gerhard Gross , Claas Wodarczyk , Kristin Verschueren
发明人： Dan Gazit , Gadi Pelled , Gadi Turgeman , Andrea Hoffmann , Gerhard Gross , Claas Wodarczyk , Kristin Verschueren
IPC分类号： A61K35/12 , A61K31/7105 , A61K31/711 , A61P19/08 , A61P19/10 , A61P19/02
CPC分类号： C12N9/1205 , A61K31/38
摘要： This invention is directed to methods, nucleic acids and compositions in TAK1-mediated regulation of SMAD activity. Promotion of TAK1 interaction with MH2 domains in SMADs negatively regulates SMAD biological activity. BMP-mediated SMAD activity is subject to TAK1 effects.
摘要翻译： 本发明涉及TAK1介导的SMAD活性调节中的方法，核酸和组合物。 促进与SMAD中MH2结构域的TAK1相互作用负调控SMAD生物活性。 BMP介导的SMAD活性受TAK1作用。
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公开(公告)号：US20050272678A1
公开(公告)日：2005-12-08
申请号：US11053666
申请日：2005-02-09
申请人： Peter Van Bodine , Dan Gazit
发明人： Peter Van Bodine , Dan Gazit
摘要： This invention is directed to a BMP-6 ERE nucleic acid sequence, vectors, cells and compositions comprising same. This invention also provides methods for identification of estrogen agonists, antagonists and therapeutic applications of same. This invention also provides methods of treating conditions, which are associated with estrogen insufficiency or with lack of response to external estrogen or agonists thereof utilizing sequences, vectors, cells and/or compositions described herein.
摘要翻译： 本发明涉及BMP-6 ERE核酸序列，载体，细胞和包含其的组合物。 本发明还提供鉴定雌激素激动剂，拮抗剂及其治疗应用的方法。 本发明还提供了使用本文所述的序列，载体，细胞和/或组合物治疗与雌激素不足或与外部雌激素或其激动剂不相应的病症的方法。
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公开(公告)号：US20120078163A1
公开(公告)日：2012-03-29
申请号：US13322457
申请日：2010-05-27
申请人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
发明人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
CPC分类号： A61K38/1875 , A61L27/14 , A61L27/24 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/258 , A61L2300/414 , A61L2300/43 , A61L2430/02 , A61L2430/10
摘要： A method of generating bone or connective tissue in a subject in need thereof, the method comprising: (a) implanting a scaffold in a damaged region of the subject, the scaffold comprising a tissue growth promoting agent; and (b) enhancing uptake of the tissue growth promoting agent into cells located on the scaffold, wherein the enhancing is effected by induced poration of the cells thereby generating bone or connective tissue in the subject. Kits for generating bone or connective tissue are also provided.
摘要翻译： 一种在有需要的受试者中产生骨或结缔组织的方法，所述方法包括：（a）在受试者的受损区域植入支架，所述支架包括组织生长促进剂; 和（b）增强组织生长促进剂对位于支架上的细胞的吸收，其中通过诱导细胞培养来实现增强，从而在受试者中产生骨或结缔组织。 还提供了用于产生骨或结缔组织的试剂盒。
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10.发明申请公开(公告)号：US20090214649A1
公开(公告)日：2009-08-27
申请号：US12320594
申请日：2009-01-29
申请人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
发明人： Dan Gazit , Gadi Pelled , Zulma Gazit , Nadav Kimelman-Bleich
CPC分类号： A61L27/3843 , A61L27/225 , A61L27/3604 , A61L27/3834 , A61L27/52 , A61L27/56
摘要： Provided are fibrin or silk matrices comprising an oxygen carrier, and matrices, which comprise an oxygen carrier and mesenchymal stem cells. Also provided are methods of generating and using same for ex vivo or in vivo tissue regeneration and/or repair such as for treating a non-union bone fracture and a condition requiring spinal fusion.
摘要翻译： 提供了包含氧载体的纤维蛋白或丝素基质和包含氧载体和间充质干细胞的基质。 还提供了用于离体或体内组织再生和/或修复的方法，例如用于治疗非并发骨折和需要脊柱融合的病症。
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