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    Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5
    1.
    发明申请
    Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 审中-公开
    联吡啶胺和醚作为代谢型谷氨酸受体-5的调节剂

    公开(公告)号：US20070027321A1

    公开(公告)日：2007-02-01

    申请号：US10570068

    申请日：2004-08-27

    申请人： Theodore Kamenecka ,  Jean-Michel Vernier ,  Celine Bonnefous ,  Steven Govek ,  John Hutchinson

    发明人： Theodore Kamenecka ,  Jean-Michel Vernier ,  Celine Bonnefous ,  Steven Govek ,  John Hutchinson

    IPC分类号： A61K31/4743 ,  C07D471/02 ,  C07D401/02 ,  C07D417/14

    CPC分类号： C07D213/74 ,  C04B35/632 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D491/04

    摘要： The present invention is directed to novel bipyridyl amine and ether compounds such as those of Formula (I): (I) (where R?1#191, R?2#191, R?3#191, X and Y are as defined herein) which are mGluR5 modulators useful in the treatment or prevention of diseases and conditions in which mGluR5 is involved, including but not limited to psychiatric and mood disorders such as schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders, such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal, obesity and other diseases. The invention is also directed to pharmaceutical compositions comprising these compounds. This invention further provides a method of treatment of these disorders and conditions by the administration of an effective amount of these novel bipyridyl amine and/or ether compounds and/or compositions containing these compounds.

    摘要翻译： 本发明涉及新型联吡啶胺和醚化合物，例如式（I）的那些：（I）（其中R 1＃191，R 2＃191，R 3＃191，X和Y如上所定义） 这是mGluR5调节剂，其可用于治疗或预防涉及mGluR5的疾病和病症，包括但不限于精神和心境障碍如精神分裂症，焦虑，抑郁，双相情感障碍和恐慌，以及在 治疗疼痛，帕金森病，认知功能障碍，癫痫，昼夜节律和睡眠障碍，如转移工作诱导的睡眠障碍和时差，药物成瘾，药物滥用，药物戒断，肥胖症等疾病。 本发明还涉及包含这些化合物的药物组合物。 本发明还提供了通过施用有效量的这些新型联吡啶胺和/或醚化合物和/或含有这些化合物的组合物来治疗这些病症和病症的方法。

    Pyrimidine and Quinoline Potentiators of Metabotropic Glutamate Receptors
    4.
    发明申请
    Pyrimidine and Quinoline Potentiators of Metabotropic Glutamate Receptors 审中-公开
    代谢型谷氨酸受体的嘧啶和喹啉电位

    公开(公告)号：US20070287716A1

    公开(公告)日：2007-12-13

    申请号：US11665422

    申请日：2005-10-24

    申请人： Essa Hu ,  Jean-Michel Vernier ,  Peter Chua ,  John Hutchinson ,  Nicholas Cosford

    发明人： Essa Hu ,  Jean-Michel Vernier ,  Peter Chua ,  John Hutchinson ,  Nicholas Cosford

    IPC分类号： A61K31/47 ,  A61P25/00 ,  C07D215/12 ,  C07D239/28

    CPC分类号： C07D239/26 ,  C07D215/06

    摘要： The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

    摘要翻译： 本发明涉及作为代谢型谷氨酸受体的增强剂（包括mGluR2受体）的化合物，其可用于治疗或预防与谷氨酸能力障碍相关的神经和精神病学障碍以及其中涉及代谢型谷氨酸受体的疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及代谢型谷氨酸受体的疾病中的用途。

    Methods for correction of spinal deformities
    7.
    发明授权
    Methods for correction of spinal deformities 有权
    矫正脊柱畸形的方法

    公开(公告)号：US08556941B2

    公开(公告)日：2013-10-15

    申请号：US13205248

    申请日：2011-08-08

    申请人： John Hutchinson

    发明人： John Hutchinson

    IPC分类号： A61B17/70

    CPC分类号： A61B17/88 ,  A61B17/7002 ,  A61B17/7032 ,  A61B17/7038

    摘要： A method of treating a spinal column shape deformation includes fixing at least two fixation screw assemblies to respective vertebrae, sliding a rod between the arm extensions on each of the fixation screw assemblies, swinging the channels of the screw assemblies relative to the fixation screws so that the channels become less inclined to the axes of the fixation screws, and so that the rod is located generally posteriorly of the spinal column, locking the channel against swinging relative to the screw, rotating the rod about its axis relative to at least one of the channels, and locking the rod against movement relative to the channel.

    摘要翻译： 治疗脊柱形变形的方法包括将至少两个固定螺钉组件固定到相应的椎骨上，在每个固定螺钉组件上的臂延伸部之间滑动杆，相对于固定螺钉摆动螺钉组件的通道，使得 通道变得不那么倾向于固定螺钉的轴线，并且使得杆大体位于脊柱的后方，锁定通道相对于螺钉摆动，相对于其中的至少一个将杆绕其轴线旋转 通道，并且锁定杆相对于通道的运动。

    Methods for Correction of Spinal Deformities
    8.
    发明申请
    Methods for Correction of Spinal Deformities 有权
    矫正脊柱畸形的方法

    公开(公告)号：US20110295321A1

    公开(公告)日：2011-12-01

    申请号：US13205248

    申请日：2011-08-08

    申请人： John Hutchinson

    发明人： John Hutchinson

    IPC分类号： A61B17/88

    CPC分类号： A61B17/88 ,  A61B17/7002 ,  A61B17/7032 ,  A61B17/7038

    摘要： A method of treating a spinal column shape deformation includes fixing at least two fixation screw assemblies to respective vertebrae, sliding a rod between the arm extensions on each of the fixation screw assemblies, swinging the channels of the screw assemblies relative to the fixation screws so that the channels become less inclined to the axes of the fixation screws, and so that the rod is located generally posteriorly of the spinal column, locking the channel against swinging relative to the screw, rotating the rod about its axis relative to at least one of the channels, and locking the rod against movement relative to the channel.

    摘要翻译： 治疗脊柱形变形的方法包括将至少两个固定螺钉组件固定到相应的椎骨上，在每个固定螺钉组件上的臂延伸部之间滑动杆，相对于固定螺钉摆动螺钉组件的通道，使得 通道变得不那么倾向于固定螺钉的轴线，并且使得杆大体位于脊柱的后方，锁定通道相对于螺钉摆动，相对于其中的至少一个将杆绕其轴线旋转 通道，并且锁定杆相对于通道的运动。

    Apparatus and method for producing water from air
    10.
    发明申请
    Apparatus and method for producing water from air 失效
    用于从空气中生产水的设备和方法

    公开(公告)号：US20050097901A1

    公开(公告)日：2005-05-12

    申请号：US10977143

    申请日：2004-10-29

    申请人： John Hutchinson

    发明人： John Hutchinson

    IPC分类号： B01D5/00 ,  E03B3/28 ,  F25D17/06 ,  F25D21/14

    CPC分类号： B01D5/0081 ,  B01D5/0039 ,  B01D5/0051 ,  E03B3/28 ,  Y02A20/109

    摘要： An apparatus and method are extracting water from the ambient air comprising drawing air through an particle ionizer grid, evaporator plates of a refrigerant system the system and recirculating the ionized air and mixing said ionized air with ambient air and recycling said mixed air through said ionizer and evaporator plates to extract moisture from the air. The system utilizes sensors to constantly sense and predictively respond to multiple parameters, monitored at multiple points in the system to predictively and efficiently adjust the system operation to continually maximize the extraction of water regardless of ambient temperature and humidity.

    摘要翻译： 一种装置和方法是从环境空气中提取水，包括抽吸空气通过颗粒离子发生器网格，制冷剂系统的蒸发器板系统并使离子化空气再循环并将所述离子化空气与环境空气混合，并将所述混合空气再循环通过所述离子发生器和 蒸发器板从空气中提取水分。 该系统利用传感器不断地感测和预测性地响应多个参数，在系统的多个点进行监测，以预测和有效地调整系统运行，以连续地最大限度地提取水，而不管环境温度和湿度如何。