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公开(公告)号:US5527819A
公开(公告)日:1996-06-18
申请号:US488957
申请日:1995-06-07
申请人: Theresa M. Williams , Terrence M. Ciccarone , Walfred S. Saari , John S. Wai , William J. Greenlee , Suresh K. Balani , Mark E. Goldman , Anthony D. Theoharides, deceased , Jacob M. Hoffman, Jr. , William C. Lumma, Jr. , Joel R. Huff , Clarence S. Rooney , Philip E. Sanderson
发明人: Theresa M. Williams , Terrence M. Ciccarone , Walfred S. Saari , John S. Wai , William J. Greenlee , Suresh K. Balani , Mark E. Goldman , Anthony D. Theoharides, deceased , Jacob M. Hoffman, Jr. , William C. Lumma, Jr. , Joel R. Huff , Clarence S. Rooney , Philip E. Sanderson
IPC分类号: C07D209/12 , C07D209/30 , C07D209/42 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/06 , C07D417/12 , C07D521/00 , A61K31/40
CPC分类号: C07D231/12 , C07D209/12 , C07D209/30 , C07D209/42 , C07D233/56 , C07D249/08 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/06 , C07D417/12
摘要: Novel indole compounds inhibit HIV reverse transcriptase, and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
摘要翻译: 新型吲哚化合物抑制HIV逆转录酶,可用于预防或治疗艾滋病毒和艾滋病感染,作为化合物,药学上可接受的盐,药物组合物成分,无论是否与其他抗病毒药物结合使用,抗感染药物 ,免疫调节剂,抗生素或疫苗。 还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。
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公开(公告)号:US5977134A
公开(公告)日:1999-11-02
申请号:US985320
申请日:1997-12-04
申请人: Terrence M. Ciccarone , Wasyl Halczenko , John H. Hutchinson , William C. Lumma, Jr. , Gerald E. Stokker , Craig A. Stump , Theresa M. Williams
发明人: Terrence M. Ciccarone , Wasyl Halczenko , John H. Hutchinson , William C. Lumma, Jr. , Gerald E. Stokker , Craig A. Stump , Theresa M. Williams
IPC分类号: C07D235/30 , C07D401/06 , C07D403/06 , C07D471/04 , C07D401/02 , A61K31/415 , A61K31/47
CPC分类号: C07D401/06 , C07D235/30 , C07D403/06 , C07D471/04
摘要: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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公开(公告)号:US4082844A
公开(公告)日:1978-04-04
申请号:US696255
申请日:1976-06-15
IPC分类号: C07D241/16 , C07D241/24 , A61K31/495 , C07D241/10
CPC分类号: C07D241/24 , C07D241/16 , Y10S514/91
摘要: The compound 6-chloro-2-(1'-piperazinyl)pyrazine, its N-oxides and acid-addition salts are disclosed having pharmacological activity as anorexic agents.
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公开(公告)号:US4081542A
公开(公告)日:1978-03-28
申请号:US774565
申请日:1977-03-04
IPC分类号: C07D241/16 , C07D241/20 , C07D241/24 , C07D295/12 , A61K31/495
CPC分类号: C07D241/24 , C07D241/16 , C07D241/20 , Y10S514/91
摘要: Compounds of the formula: ##STR1## and their N-oxides and acid-addition salts are disclosed having pharmacological activity as anorexic agents.
摘要翻译: 公开了具有下式的化合物:其具有作为厌食剂的药理活性的N-氧化物和酸加成盐。
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公开(公告)号:US4163849A
公开(公告)日:1979-08-07
申请号:US887693
申请日:1978-03-17
IPC分类号: C07D241/20 , A61K31/495 , C07D403/04
CPC分类号: C07D241/20 , Y10S514/91
摘要: Substituted piperazinylpyrazines and pharmaceutically acceptable salts thereof which have pharmacological activity as anorexigenic agents.
摘要翻译: 具有药理活性的取代哌嗪基吡嗪及其药学上可接受的盐作为厌食症剂。
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公开(公告)号:US4091101A
公开(公告)日:1978-05-23
申请号:US806898
申请日:1977-06-15
IPC分类号: C07D241/44 , A61K31/495 , A61P3/04 , A61P25/04 , A61P25/20 , A61P25/24 , A61P25/26 , C07D241/42 , C07D295/135 , C07D241/40
CPC分类号: C07D295/135 , C07D241/42
摘要: 6-(1-Piperazinyl)quinoxaline and pharmaceutically acceptable salts thereof have serotoninmimetic activity. It is prepared by reducing the nitro group of 1-(3-amino-4-nitrophenyl)piperazine followed by treatment with glyoxal.
摘要翻译: {PG,1,6-(1-哌嗪基)喹喔啉及其药学上可接受的盐具有5-羟色胺模拟活性。 通过还原1-(3-氨基-4-硝基苯基)哌嗪的硝基,然后用乙二醛处理制备。
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公开(公告)号:US4082845A
公开(公告)日:1978-04-04
申请号:US790362
申请日:1977-04-25
IPC分类号: A61K31/33 , A61P3/04 , A61P25/04 , A61P25/24 , A61P25/26 , C07D471/04 , A61K31/495 , C07D295/12
CPC分类号: C07D471/04 , Y10S514/91
摘要: 3-(1-Piperazinyl)-pyrido[2,3-b]pyrazines and pharmaceutically acceptable salts thereof have serotoninmimetic activity. They are prepared by treating 3-halo-pyrido[2,3-b]pyrazines with piperazine.
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公开(公告)号:US4078063A
公开(公告)日:1978-03-07
申请号:US726713
申请日:1976-09-24
IPC分类号: C07D213/74 , A61K31/495 , A61K31/50 , A61P3/04 , C07D20060101 , C07D295/12 , C07D401/04
CPC分类号: C07D401/12 , Y10S514/91
摘要: Compounds of the formula: ##STR1## and their N-oxides and acid-addition salts are disclosed having pharmacological activity as anorexic agents.
摘要翻译: 公开了具有下式的化合物:其具有作为厌食剂的药理活性的N-氧化物和酸加成盐。
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公开(公告)号:US07115597B2
公开(公告)日:2006-10-03
申请号:US10677687
申请日:2003-10-02
申请人: Mark T. Bilodeau , George D. Hartman , Jacob M. Hoffman, Jr. , John T. Sisko , Peter J. Manley , Anthony M. Smith , Thomas J. Tucker , William C. Lumma, Jr. , Leonard Rodman
发明人: Mark T. Bilodeau , George D. Hartman , Jacob M. Hoffman, Jr. , John T. Sisko , Peter J. Manley , Anthony M. Smith , Thomas J. Tucker , William C. Lumma, Jr. , Leonard Rodman
IPC分类号: C07D417/12 , A61K31/427 , C07D241/04
CPC分类号: C07D403/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/04 , C07D487/08 , C07D491/08
摘要: The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
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公开(公告)号:US5939439A
公开(公告)日:1999-08-17
申请号:US995744
申请日:1997-12-22
申请人: Neville J. Anthony , Samuel L. Graham , Lekhanh O. Tran , Ian M. Bell , S. Jane deSolms , Robert P. Gomez , Michelle Sparks Kuo , William C. Lumma, Jr. , Debra S. Perlow , Anthony W. Shaw , John S. Wai , Steven D. Young
发明人: Neville J. Anthony , Samuel L. Graham , Lekhanh O. Tran , Ian M. Bell , S. Jane deSolms , Robert P. Gomez , Michelle Sparks Kuo , William C. Lumma, Jr. , Debra S. Perlow , Anthony W. Shaw , John S. Wai , Steven D. Young
IPC分类号: C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/14 , C07D417/14 , C07D471/04 , C07D401/04 , A61K31/44
CPC分类号: C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/14 , C07D417/14 , C07D471/04
摘要: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
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