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公开(公告)号:US07632834B2
公开(公告)日:2009-12-15
申请号:US12101462
申请日:2008-04-11
申请人: Thierry Bouyssou , Ingo Konetzki , Philipp Lustenberger , Juergen Mack , Andreas Schnapp , Dieter Wiedenmayer , Christoph Hoenke , Klaus Rudolf
发明人: Thierry Bouyssou , Ingo Konetzki , Philipp Lustenberger , Juergen Mack , Andreas Schnapp , Dieter Wiedenmayer , Christoph Hoenke , Klaus Rudolf
IPC分类号: A61K31/538 , A61K31/536 , C07D413/12 , C07D413/14
CPC分类号: C07D265/36 , C07D413/12
摘要: A compound of formula 1′″ wherein: V is —CH2—, —NH—, or —O—; Ra and Rb are each independently hydrogen, C1-4-alkyl, or halogen-C1-4-alkyl, or Ra and Rb together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R1 and R1′ are each independently hydrogen, C1-6-alkyl, C3-6-cycloalkyl, halogen-C1-6-alkyl, halogen-C3-6-cycloalkyl, or C1-6-alkylene-C3-6-cycloalkyl, or R1 and R1′ together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R2, R2′, R2″, and R2′″ are each independently hydrogen, C1-6-alkyl, halogen-C1-6-alkylene, OH, HO—C1-6-alkylene, —O—C1-6-alkyl, C6-10-aryl, C6-10-aryl-C1-4-alkylene, C6-10-aryl-C1-6-alkylene-O, COOH, COOC1-6-alkyl, O—C1-6-alkylene-COOH, O—C1-6-alkylene-COOC1-6-alkyl, NHSO2—C1-6-alkyl, CN, NH2, NH—C1-6-alkyl, N(C1-6-alkyl)2, NO2, S—C1-6-alkyl, SO2—C1-6-alkyl, SO—C1-6-alkyl, O(CO)C1-6-alkyl, COC1-6-alkyl, NHCOC1-6-alkyl, or halogen; and n is 0, 1, or 2, or an optical isomer thereof, or a corresponding acid addition salt thereof with a pharmacologically acceptable acid, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.
摘要翻译: 式1“'的化合物,其中:V是-CH 2 - , - NH-或-O-; R a和R b各自独立地为氢,C 1-4 - 烷基或卤素-C 1-4 - 烷基,或者R a和R b一起是C 2-5亚烷基桥,其中一个或多个氢原子任选被卤素取代; R 1和R 1'各自独立地为氢,C 1-6 - 烷基,C 3-6 - 环烷基,卤素-C 1-6 - 烷基,卤素-C 3-6环烷基或C 1-6亚烷基-C 3-6环烷基, 或者R1和R1'一起是C2-5亚烷基桥,其中一个或多个氢原子任选地被卤素取代; R 2,R 2',R 2“和R 2”各自独立地为氢,C 1-6 - 烷基,卤素-C 1-6亚烷基,OH,HO-C 1-6 - 亚烷基,-O-C 1-6 - 烷基,C 6-10 - 芳基,C 6-10 - 芳基-C 1-4 - 亚烷基,C 6-10 - 芳基-C 1-6 - 亚烷基-O,COOH,COOC 1-6 - 烷基,O-C 1-6亚烷基 - COOH,O-C 1-6亚烷基-COOC 1-6 - 烷基,NHSO 2 -C 1-6 - 烷基,CN,NH 2,NH-C 1-6 - 烷基,N(C 1-6 - 烷基)2,NO 2, C 1-6 - 烷基,SO 2 -C 1-6 - 烷基,SO-C 1-6 - 烷基,O(CO)C 1-6 - 烷基,CO C 1-6 - 烷基,NHCOC 1-6 - 烷基或卤素; 和n为0,1或2,或其光学异构体或其与药理学上可接受的酸的相应的酸加成盐,以及其作为药物组合物的用途,特别是用于治疗炎性和阻塞性呼吸道疾病。
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公开(公告)号:US07375104B2
公开(公告)日:2008-05-20
申请号:US11600417
申请日:2006-11-15
申请人: Thierry Bouyssou , Ingo Konetzki , Philipp Lustenberger , Juergen Mack , Andreas Schnapp , Dieter Wiedenmayer , Christoph Hoenke , Klaus Rudolf
发明人: Thierry Bouyssou , Ingo Konetzki , Philipp Lustenberger , Juergen Mack , Andreas Schnapp , Dieter Wiedenmayer , Christoph Hoenke , Klaus Rudolf
IPC分类号: C07D413/12 , C07D413/14 , A61K31/538 , A61K31/536
CPC分类号: C07D265/36 , C07D413/12
摘要: A compound of formula 1′ wherein: V is —CH2—, —NH—, or —O—; Ra and Rb are each independently hydrogen, C1-4-alkyl, or halogen-C1-4-alkyl, or Ra and Rb together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R1 and R1′ are each independently hydrogen, C1-6-alkyl, C3-6-cycloalkyl, halogen-C1-6-alkyl, halogen-C3-6-cycloalkyl, or C1-6-alkylene-C3-6-cycloalkyl, or R1 and R1′ together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R2, R2′, R2″, and R′″ are each independently hydrogen, C1-6-alkyl, halogen-C1-6-alkylene, OH, HO—C1-6-alkylene, —O—C1-6-alkyl, C6-10-aryl, C6-10-aryl-C1-4-alkylene, C6-10-aryl-C1-6-alkylene-O, COOH, COOC1-6-alkyl, O—C1-6-alkylene-COOH, O—C1-6-alkylene-COOC1-6-alkyl, NHSO2—C1-6-alkyl, CN, NH2, NH—C1-6-alkyl, N(C1-6-alkyl)2, NO2, S—C1-6-alkyl, SO2—C1-6-alkyl, SO—C1-6-alkyl, O(CO)C1-6-alkyl, COC1-6-alkyl, NHCOC1-6-alkyl, or halogen; and n is 0, 1, or 2, or an optical isomer thereof, or a corresponding acid addition salt thereof with a pharmacologically acceptable acid, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.
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公开(公告)号:US20050227975A1
公开(公告)日:2005-10-13
申请号:US11029451
申请日:2005-01-05
申请人: Thierry Bouyssou , Ingo Konetzki , Philipp Lustenberger , Juergen Mack , Andreas Schnapp , Dieter Wiedenmayer , Christoph Hoenke , Klaus Rudolf
发明人: Thierry Bouyssou , Ingo Konetzki , Philipp Lustenberger , Juergen Mack , Andreas Schnapp , Dieter Wiedenmayer , Christoph Hoenke , Klaus Rudolf
IPC分类号: A61K31/4709 , A61K31/517 , A61K31/538 , C07D265/36 , C07D413/02 , C07D413/12 , C07D43/02
CPC分类号: C07D265/36 , C07D413/12
摘要: The present invention relates to compounds of formula 1 wherein the groups X, Ra, Rb, R1, R1′, R2, R2′, R2″, R2′″, V and n may have the meanings given in the claims and in the specification, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.
摘要翻译: 本发明涉及式1的化合物,其中基团X,R a,R b,R 1,R 1, R 2,R 2,R 2,R“2”,R“2”,R“2” ,V和n可以具有权利要求书和说明书中给出的含义,以及其作为药物组合物的用途,特别是用于治疗炎性和阻塞性呼吸道疾病。
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公开(公告)号:US07160882B2
公开(公告)日:2007-01-09
申请号:US11029451
申请日:2005-01-05
申请人: Thierry Bouyssou , Ingo Konetzki , Philipp Lustenberger , Juergen Mack , Andreas Schnapp , Dieter Wiedenmayer , Christoph Hoenke , Klaus Rudolf
发明人: Thierry Bouyssou , Ingo Konetzki , Philipp Lustenberger , Juergen Mack , Andreas Schnapp , Dieter Wiedenmayer , Christoph Hoenke , Klaus Rudolf
IPC分类号: C07D413/12 , C07D413/14 , A61K31/538 , A61K31/536
CPC分类号: C07D265/36 , C07D413/12
摘要: The present invention relates to compounds of formula 1 wherein the groups X, Ra, Rb, R1, R1′, R2, R2′, R2″, R2′″, V and n may have the meanings given in the claims and in the specification, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.
摘要翻译: 本发明涉及式1的化合物,其中基团X,R a,R b,R 1,R 1, R 2,R 2,R 2,R“2”,R“2”,R“2” ,V和n可以具有权利要求书和说明书中给出的含义,以及其作为药物组合物的用途,特别是用于治疗炎性和阻塞性呼吸道疾病。
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公开(公告)号:US20070066609A1
公开(公告)日:2007-03-22
申请号:US11600417
申请日:2006-11-15
申请人: Thierry Bouyssou , Ingo Konetzki , Philipp Lustenberger , Juergen Mack , Andreas Schnapp , Dieter Wiedenmayer , Christoph Hoenike , Klaus Rudolf
发明人: Thierry Bouyssou , Ingo Konetzki , Philipp Lustenberger , Juergen Mack , Andreas Schnapp , Dieter Wiedenmayer , Christoph Hoenike , Klaus Rudolf
IPC分类号: A61K31/538 , C07D413/02
CPC分类号: C07D265/36 , C07D413/12
摘要: A compound of formula 1′ wherein: V is —CH2—, —NH—, or —O—; Ra and Rb are each independently hydrogen, C1-4-alkyl, or halogen-C1-4-alkyl, or Ra and Rb together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R1 and R1′ are each independently hydrogen, C1-6-alkyl, C3-6-cycloalkyl, halogen-C1-6-alkyl, halogen-C3-6-cycloalkyl, or C1-6-alkylene-C3-6-cycloalkyl, or R1 and R1′ together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R2, R2′, R2″, and R′″ are each independently hydrogen, C1-6-alkyl, halogen-C1-6-alkylene, OH, HO—C1-6-alkylene, —O—C1-6-alkyl, C6-10-aryl, C6-10-aryl-C1-4-alkylene, C6-10-aryl-C1-6-alkylene-O, COOH, COOC1-6-alkyl, O—C1-6-alkylene-COOH, O—C1-6-alkylene-COOC1-6-alkyl, NHSO2—C1-6-alkyl, CN, NH2, NH—C1-6-alkyl, N(C1-6-alkyl)2, NO2, S—C1-6-alkyl, SO2—C1-6-alkyl, SO—C1-6-alkyl, O(CO)C1-6-alkyl, COC1-6-alkyl, NHCOC1-6-alkyl, or halogen; and n is 0, 1, or 2, or an optical isomer thereof, or a corresponding acid addition salt thereof with a pharmacologically acceptable acid, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.
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公开(公告)号:US20050197374A1
公开(公告)日:2005-09-08
申请号:US11057893
申请日:2005-02-14
IPC分类号: A61K31/4196 , A61L9/04 , C07D249/08
CPC分类号: A61K31/4196 , C07D249/08 , C07D405/04
摘要: A compound of formula 1 wherein the groups R1, R2, R3, R4 and n may have the meanings given in the claims and in the specification, and methods for preparing a pharmaceutical composition for the treatment of inflammatory and obstructive respiratory complaints.
摘要翻译: 式1的化合物,其中基团R 1,R 2,R 3,R 4和n可以 具有权利要求书和说明书中给出的含义,以及制备用于治疗炎性和阻塞性呼吸道疾病的药物组合物的方法。
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公开(公告)号:US07405232B2
公开(公告)日:2008-07-29
申请号:US11057893
申请日:2005-02-14
IPC分类号: A61K31/41 , C07D249/08
CPC分类号: A61K31/4196 , C07D249/08 , C07D405/04
摘要: A compound of formula 1 wherein the groups R1, R2, R3, R4 and n may have the meanings given in the claims and in the specification, and methods for preparing a pharmaceutical composition for the treatment of inflammatory and obstructive respiratory complaints.
摘要翻译: 式1的化合物,其中基团R 1,R 2,R 3,R 4和n可以 具有权利要求书和说明书中给出的含义,以及制备用于治疗炎性和阻塞性呼吸道疾病的药物组合物的方法。
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公开(公告)号:US08372838B2
公开(公告)日:2013-02-12
申请号:US13031895
申请日:2011-02-22
申请人: Norbert Hauel , Angelo Ceci , Henri Doods , Ingo Konetzki , Juergen Mack , Henning Priepke , Annette Schuler-Metz , Rainer Walter , Dieter Wiedenmayer
发明人: Norbert Hauel , Angelo Ceci , Henri Doods , Ingo Konetzki , Juergen Mack , Henning Priepke , Annette Schuler-Metz , Rainer Walter , Dieter Wiedenmayer
IPC分类号: A61K31/50 , A61K31/501
CPC分类号: C07D405/12 , C07C237/24 , C07C2601/02 , C07D207/277 , C07D211/62 , C07D213/81 , C07D233/90 , C07D239/28 , C07D239/557 , C07D261/18 , C07D271/10 , C07D401/12
摘要: Compounds of the formula I wherein n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and X are defined as described in the specification, which are bradykinin B1 antagonists, and their use as medicaments.
摘要翻译: 其中n,R1,R2,R3,R4,R5,R6,R7,R8,R9,R10,R11和X如说明书中所描述的缓激肽B1拮抗剂及其作为药物的用途的式I化合物 。
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公开(公告)号:US08916589B2
公开(公告)日:2014-12-23
申请号:US12675224
申请日:2008-08-28
申请人: Norbert Hauel , Angelo Ceci , Enzo Cereda , Henri Doods , Ingo Konetzki , Juergen Mack , Henning Priepke , Annette Schuler-Metz , Rainer Walter
发明人: Norbert Hauel , Angelo Ceci , Enzo Cereda , Henri Doods , Ingo Konetzki , Juergen Mack , Henning Priepke , Annette Schuler-Metz , Rainer Walter
IPC分类号: A61K31/44 , A61K31/41 , C07D239/28 , C07C237/24 , C07C317/44 , C07D209/42 , C07D213/64 , C07D213/82 , C07D233/90 , C07D237/24 , C07D239/34 , C07D239/36 , C07D239/42 , C07D261/18 , C07D263/34 , C07D277/56 , C07D307/68 , C07K5/062 , C07K5/078
CPC分类号: C07D239/28 , C07C237/24 , C07C317/44 , C07C2601/02 , C07D209/42 , C07D213/64 , C07D213/82 , C07D233/90 , C07D237/24 , C07D239/34 , C07D239/36 , C07D239/42 , C07D261/18 , C07D263/34 , C07D277/56 , C07D307/68 , C07K5/06026 , C07K5/06139
摘要: The present invention relates to compounds of general formula I wherein n, R1, R2, R3, R4, R5, R6, R7 and R8 are defined as stated hereinafter, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable properties, the preparation thereof, the pharmaceutical compositions containing the pharmacologically effective compounds, the preparation thereof and the use thereof.
摘要翻译: 本发明涉及通式I的化合物,其中n,R 1,R 2,R 3,R 4,R 5,R 6,R 7和R 8如下文所定义,对映异构体,非对映体,其混合物及其盐, 其有机或无机酸或碱的生理上可接受的盐,其具有有价值的性质,其制备,含有药理学有效化合物的药物组合物,其制备及其用途。
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公开(公告)号:US20050014810A1
公开(公告)日:2005-01-20
申请号:US10744830
申请日:2003-12-23
申请人: Ruediger Streicher , Juergen Mack , Rainer Walter , Ingo Konetzki , Thomas Trieselmann , Volkhard Austel
发明人: Ruediger Streicher , Juergen Mack , Rainer Walter , Ingo Konetzki , Thomas Trieselmann , Volkhard Austel
IPC分类号: A61K31/4184
CPC分类号: A61K31/4184
摘要: The present invention relates to the use of a substituted 2-phenylbenzimidazole of formula I wherein R1, R2, R3, R4, R5 and m have the meanings given in the claims, for the preparation of a medicament for the treatment or prevention of diseases involving glucagon receptors, as well as new compounds of formula I wherein R1 is a group of formula
摘要翻译: 本发明涉及式I的取代的2-苯基苯并咪唑的用途,其中R 1,R 2,R 3,R 4,R 5和m具有权利要求书中给出的含义 ,用于制备用于治疗或预防涉及胰高血糖素受体的疾病的药物,以及新的式I化合物,其中R 1是式
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