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1.Methods Of Forming Coatings For Implantable Medical Devices For Controlled Release Of A Peptide And A Hydrophobic Drug 审中-公开
标题翻译: 形成用于控制释放肽和疏水药物的可植入医疗装置的涂层的方法公开(公告)号:US20090258028A1
公开(公告)日:2009-10-15
申请号:US12424489
申请日:2009-04-15
申请人: Thierry Glauser , Syed F.A. Hossainy , Irina Astafieva , Florencia Lim , Xinmin Xu , Bozena Z. Maslanka , Mikael O. Trollsas , Michael H. Ngo
发明人: Thierry Glauser , Syed F.A. Hossainy , Irina Astafieva , Florencia Lim , Xinmin Xu , Bozena Z. Maslanka , Mikael O. Trollsas , Michael H. Ngo
IPC分类号: A61K38/00 , A61K39/395
CPC分类号: A61L31/10 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2300/416 , A61L2300/606 , C08L33/14 , C08L75/04
摘要: This invention is generally related to methods of forming coatings for implantable medical devices, such as drug delivery vascular stents. The methods are for forming coatings to control the release of a peptide such as RGD, and a hydrophobic drug. Both single layer and multiple layer coating constructs are encompassed in the various embodiments of the present invention.
摘要翻译: 本发明通常涉及形成用于可植入医疗装置(例如药物输送血管支架)的涂层的方法。 所述方法用于形成涂层以控制肽如RGD和疏水性药物的释放。 单层和多层涂层构造都包含在本发明的各种实施方案中。
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公开(公告)号:US20110293675A1
公开(公告)日:2011-12-01
申请号:US13206417
申请日:2011-08-09
CPC分类号: A61K47/32 , A61F2/82 , A61K45/06 , A61K47/65 , A61K47/6957 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L33/26
摘要: An implantable device including conjugate formed of an acrylamide-based copolymer and a bioactive agent is provided.
摘要翻译: 提供了包括由丙烯酰胺类共聚物和生物活性剂形成的共轭物的可植入装置。
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3.COATINGS FOR IMPLANTABLE DEVICES COMPRISING POLYMERS OF LACTIC ACID AND METHODS FOR FABRICATING THE SAME 有权
标题翻译: 包含乳酸聚合物的可植入装置的涂料及其制造方法公开(公告)号:US20110027336A1
公开(公告)日:2011-02-03
申请号:US12762718
申请日:2010-04-19
申请人: Syed F.A. Hossainy , Yiwen Tang , Eugene T. Michal , Thierry Glauser , Stephen D. Pacetti , Jessica DesNoyer
发明人: Syed F.A. Hossainy , Yiwen Tang , Eugene T. Michal , Thierry Glauser , Stephen D. Pacetti , Jessica DesNoyer
IPC分类号: A61F2/00 , B05D1/00 , A61K31/436 , A61P9/00 , A61F2/82
CPC分类号: A61L31/10 , A61F2250/0067 , A61L27/28 , A61L27/34 , A61L29/08 , A61L29/085 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2420/00 , A61L2420/02 , A61L2420/06 , C08L67/04
摘要: Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.
摘要翻译: 公开了用于可植入医疗装置的涂层及其制造方法,所述涂层包含乳酸聚合物。
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公开(公告)号:US20090041845A1
公开(公告)日:2009-02-12
申请号:US11891131
申请日:2007-08-08
申请人: Lothar Walter Kleiner , Jessica Renee DesNoyer , Bozena Zofia Maslanka , Mikael Trollsas , Syed F.A. Hossainy , Yiwen Tang , Thierry Glauser , Michael Ngo
发明人: Lothar Walter Kleiner , Jessica Renee DesNoyer , Bozena Zofia Maslanka , Mikael Trollsas , Syed F.A. Hossainy , Yiwen Tang , Thierry Glauser , Michael Ngo
IPC分类号: A61K9/00 , A61K31/436
CPC分类号: A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2420/06
摘要: Disclosed herein is a coating having a layer that includes a matrix phase and a dispersed phase substantially immiscible in the matrix phase and methods of using the same.
摘要翻译: 本文公开了一种涂层,其具有包括基质相和在基质相中基本上不混溶的分散相的层及其使用方法。
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5.Methods For Fabricating Coatings For Drug Delivery Devices Having Gradient Of Hydration 有权
标题翻译: 用于制备具有水化梯度的药物递送装置的涂层的方法公开(公告)号:US20080138498A1
公开(公告)日:2008-06-12
申请号:US12016820
申请日:2008-01-18
IPC分类号: A61L27/26
CPC分类号: A61L31/10 , A61F2250/0067 , A61L2420/08 , Y10T428/24942 , Y10T428/3154 , Y10T428/31544 , Y10T428/31551 , Y10T428/31565 , Y10T428/31573 , Y10T428/31576 , Y10T428/31786 , Y10T428/31797 , Y10T428/31855 , Y10T428/31909 , Y10T428/31928 , Y10T428/31935
摘要: A method for fabricating a coating for an implantable medical device is provided comprising applying a first polymer on at least a portion of the device to form a first layer of the coating and applying a second polymer on at least a portion of the first layer to form a second layer of the coating. The second polymer has a lower degree of hydration than the first polymer.
摘要翻译: 提供了一种用于制造可植入医疗装置的涂层的方法,包括在所述装置的至少一部分上施加第一聚合物以形成所述涂层的第一层,并在所述第一层的至少一部分上施加第二聚合物以形成 涂层的第二层。 第二聚合物的水合度比第一聚合物低。
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6.Coatings for implantable devices comprising polymers of lactic acid and methods for fabricating the same 有权
标题翻译: 用于包含乳酸聚合物的可植入装置的涂层及其制造方法公开(公告)号:US08846069B2
公开(公告)日:2014-09-30
申请号:US12762718
申请日:2010-04-19
申请人: Syed F.A. Hossainy , Yiwen Tang , Eugene T. Michal , Thierry Glauser , Stephen D. Pacetti , Jessica DesNoyer
发明人: Syed F.A. Hossainy , Yiwen Tang , Eugene T. Michal , Thierry Glauser , Stephen D. Pacetti , Jessica DesNoyer
CPC分类号: A61L31/10 , A61F2250/0067 , A61L27/28 , A61L27/34 , A61L29/08 , A61L29/085 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2420/00 , A61L2420/02 , A61L2420/06 , C08L67/04
摘要: Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.
摘要翻译: 公开了用于可植入医疗装置的涂层及其制造方法,所述涂层包含乳酸聚合物。
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7.Methods For Fabricating Coatings For Drug Delivery Devices Having Gradient Of Hydration 有权
标题翻译: 用于制备具有水化梯度的药物递送装置的涂层的方法公开(公告)号:US20080138497A1
公开(公告)日:2008-06-12
申请号:US12016804
申请日:2008-01-18
IPC分类号: A61L27/26
CPC分类号: A61L31/10 , A61F2250/0067 , A61L2420/08 , Y10T428/24942 , Y10T428/3154 , Y10T428/31544 , Y10T428/31551 , Y10T428/31565 , Y10T428/31573 , Y10T428/31576 , Y10T428/31786 , Y10T428/31797 , Y10T428/31855 , Y10T428/31909 , Y10T428/31928 , Y10T428/31935
摘要: A method for fabricating a coating for an implantable medical device is provided comprising applying a first polymer on at least a portion of the device to form a first layer of the coating and applying a second polymer on at least a portion of the first layer to form a second layer of the coating. The second polymer has a higher degree of hydration than the first polymer. The first or second polymer can comprise a polyorthoester.
摘要翻译: 提供了一种用于制造可植入医疗装置的涂层的方法,包括在所述装置的至少一部分上施加第一聚合物以形成所述涂层的第一层,并在所述第一层的至少一部分上施加第二聚合物以形成 涂层的第二层。 第二聚合物具有比第一聚合物更高的水合度。 第一或第二聚合物可以包含聚原酸酯。
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8.POLYMERS CONTAINING POLY(ESTER AMIDES) AND AGENTS FOR USE WITH MEDICAL ARTICLES AND METHODS OF FABRICATING THE SAME 有权
标题翻译: 含有多种(酯类)的聚合物和与医药品一起使用的药剂及其制备方法公开(公告)号:US20090274741A1
公开(公告)日:2009-11-05
申请号:US12504542
申请日:2009-07-16
申请人: Stephen D. Pacetti , Charles D. Claude , Thierry Glauser , Jessica R. DesNoyer , Syed F.A. Hossainy
发明人: Stephen D. Pacetti , Charles D. Claude , Thierry Glauser , Jessica R. DesNoyer , Syed F.A. Hossainy
IPC分类号: A61K31/56 , A61K31/727 , A61P41/00
摘要: Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a polymer comprising a polymeric product of a reaction comprising a polyol, a polycarboxylic acid, an amino acid and an agent.
摘要翻译: 公开了含有聚(酯酰胺)的聚合物和用于医疗制品的试剂及其制造方法。 医疗制品通常包括具有涂层的可植入基底,并且该涂层含有包含包含多元醇,多元羧酸,氨基酸和试剂的反应的聚合产物的聚合物。
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9.Poly(amide) and poly(ester-amide) polymers and drug delivery particles and coatings containing same 有权
标题翻译: 聚(酰胺)和聚(酯 - 酰胺)聚合物和药物递送颗粒和含有它们的涂层公开(公告)号:US08916187B2
公开(公告)日:2014-12-23
申请号:US13221767
申请日:2011-08-30
CPC分类号: C08L77/12 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2300/62 , C08G69/44 , C08G69/48
摘要: The current invention relates to poly(amide) and poly(ester-amide) polymers, coatings including the polymers, and narrow polydispersity drug delivery particles including the polymers.
摘要翻译: 本发明涉及聚(酰胺)和聚(酯 - 酰胺)聚合物,包括聚合物的涂层和包括聚合物的窄多分散药物递送颗粒。
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公开(公告)号:US08333984B2
公开(公告)日:2012-12-18
申请号:US13206417
申请日:2011-08-09
IPC分类号: A61F2/00
CPC分类号: A61K47/32 , A61F2/82 , A61K45/06 , A61K47/65 , A61K47/6957 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L33/26
摘要: An implantable device including conjugate formed of an acrylamide-based copolymer and a bioactive agent is provided.
摘要翻译: 提供了包括由丙烯酰胺类共聚物和生物活性剂形成的共轭物的可植入装置。
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