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64 条记录 (耗时 0.029 秒)

    Process for preparing pyrazoles
    5.
    发明授权
    Process for preparing pyrazoles 有权
    制备吡唑的方法

    公开(公告)号：US6022979A

    公开(公告)日：2000-02-08

    申请号：US352141

    申请日：1999-07-13

    申请人： Thomas Barth ,  Norbert Rieber ,  Klaus Erhardt

    发明人： Thomas Barth ,  Norbert Rieber ,  Klaus Erhardt

    IPC分类号： C07D231/12

    CPC分类号： C07D231/12

    摘要： A process for preparing pyrazoles of the formula I ##STR1## in which R.sup.1,R.sup.2,R.sup.3 independently of one another are C.sub.1 - to C.sub.20 -alkyl, C.sub.3 - to C.sub.8 -cycloalkyl, or C.sub.7 - to C.sub.20 -aralkyl or aryl, unsubstituted or substituted by C.sub.1 - to C.sub.4 -alkyl, halogen and/or nitro,R.sup.1,R.sup.3 are additionally independently of one another hydrogen,by reacting a carbonyl compound of the formula R.sup.1 --CH.sub.2 --CO--R.sup.2, in which R.sup.1 and R.sup.2 are as defined above in the presence of a strong base witha) formic esters of the formula H--COOR.sup.4, in which R.sup.4 is C.sub.1 - to C.sub.8 -alkyl at from (-20) to 70.degree. C. and a pressure of from 1 to 50 bar orb) carbon monoxide at from 0 to 100.degree. C. and a pressure of from 1.5 to 150 barand reacting the resulting intermediate, the hydrazines of the formula R.sup.3 --NH--NH.sub.2, in which R.sup.3 is as defined above, and an inorganic or organic acid at from 0 to 90.degree. C. and a pressure of from 1 to 10 bar, which comprises filtering off or centrifuging off the intermediate, is described.

    摘要翻译： 其中R 1，R 2，R 3彼此独立地为C 1 -C 20烷基，C 3 -C 8环烷基或C 7 -C 20芳烷基或芳基，其未被取代或被C 1取代的式I的吡唑的方法 通过使式R 1 -CH 2 -CO-R 2的羰基化合物（其中R 1和R 2如上定义）在式 强碱的存在与a）式H-COOR4的甲酸酯，其中R 4是（-20）至70℃下的C 1 -C 8烷基和1至50巴的压力或b） 一氧化碳在0至100℃，压力为1.5至150巴，并使得到的中间体将式R3-NH-NH2的肼（其中R3如上定义）和无机或有机酸 描述了0至90℃和1至10巴的压力，其包括过滤或离心中间体。

    Preparation of 4-methylpyrimidines
    6.
    发明授权
    Preparation of 4-methylpyrimidines 失效
    4-甲基嘧啶的制备

    公开(公告)号：US5414086A

    公开(公告)日：1995-05-09

    申请号：US199452

    申请日：1994-02-22

    申请人： Stefan Rittinger ,  Norbert Rieber

    发明人： Stefan Rittinger ,  Norbert Rieber

    IPC分类号： C07D239/26 ,  C07D239/42 ,  C07D295/104 ,  C07D239/34 ,  C07D239/38

    CPC分类号： C07D239/26 ,  C07D239/42 ,  C07D295/104 ,  Y02P20/582

    摘要： A process for the preparation of a 4-methylpyrimidine of the general formula I ##STR1## in which R.sup.1 denotes C.sub.1 -C.sub.20 alkyl, C.sub.3 -C.sub.8 cycloalkyl, aryl, C.sub.7 -C.sub.12 phenalkyl, C.sub.7 -C.sub.12 alkylphenyl, NH.sub.2, NHCN, OH, and SH,in which a 1-aminovinyl methyl ketone of the general formula II ##STR2## in which R.sup.2 and R.sup.3 denote C.sub.1 -C.sub.20 alkyl, C.sub.3 -C.sub.8 cycloalkyl, aryl, C.sub.7 -C.sub.12 phenylalkyl, C.sub.7 -C.sub.12 alkylphenyl, C.sub.1 -C.sub.20 hydroxyalkyl or together denote a C.sub.2 -C.sub.7 alkylene chain optionally mono- to tetra-substituted by C.sub.1 -C.sub.4 alkyl and optionally interrupted by oxygen, nitrogen, or sulfur, is caused to react with a carboxamide or amidine or a salt thereof of the general formula III ##STR3## in which R.sup.1 has the aforementioned meanings and x stands for oxygen or NH, at temperatures ranging from 20.degree. to 200.degree. C. and pressures ranging from 0.01 to 50 bar.

    摘要翻译： 制备通式I（I）的4-甲基嘧啶的方法，其中R1表示C1-C20烷基，C3-C8环烷基，芳基，C7-C12苯烷基，C7-C12烷基苯基，NH2，NHCN ，OH和SH，其中通式II的1-氨基乙烯基甲基酮（II）其中R2和R3表示C1-C20烷基，C3-C8环烷基，芳基，C7-C12苯基烷基，C7-C12 烷基苯基，C 1 -C 20羟基烷基或一起表示任选被C 1 -C 4烷基单取代和四取代并任选被氧，氮或硫中断的C 2 -C 7亚烷基链与羧酰胺或脒或盐反应 其中R 1具有上述含义，x代表氧或NH，通常在20℃至200℃的温度和0.01至50巴的压力下进行。

    Preparation of 2,4-hexadiyne-1,6-diol
    7.
    发明授权
    Preparation of 2,4-hexadiyne-1,6-diol 失效
    2,4-己二炔-1,6-二醇的制备

    公开(公告)号：US5420365A

    公开(公告)日：1995-05-30

    申请号：US176825

    申请日：1994-01-03

    申请人： Stefan Rittinger ,  Norbert Rieber

    发明人： Stefan Rittinger ,  Norbert Rieber

    IPC分类号： C07C29/42 ,  C07C31/18

    CPC分类号： C07C29/42

    摘要： Process for the preparation of 2,4-hexadiyne-1,6-diol of the formula IHO-CH.sub.2 -CH.sub.2 -C.ident.C-.ident.C-CH.sub.2 -OH (I)by the reaction of diacetylene of the formula IIH-C.ident.C-C.ident.C-H (II)with formaldehyde of the formula IIIH.sub.2 C=O (III),in the presence of a silver catalysts, in which the reaction is carried out in the presence of a polar organic solvent at temperatures ranging from 0.degree. to 150.degree. C. and under pressures ranging from 0.01 to 10 bar.

    摘要翻译： 式II HO-CH2-CH2-C = C-C-C-CH2-OH（Ⅰ）的2,4-己二炔-1,6-二醇通过式II的二乙炔的反应制备方法HC = 在银催化剂存在下，CC = CH（II）与式IIIH 2 C = O（III）的甲醛反应，其中反应在极性有机溶剂存在下，在0℃至150℃的温度范围内进行 在0.01至10巴的压力下进行。