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    Inhibitors of the gastric H+, K+-atpase with enhanced therapeutic properties
    1.
    发明申请
    Inhibitors of the gastric H+, K+-atpase with enhanced therapeutic properties 有权
    抑制胃H +，K + -atpase具有增强的治疗性能

    公开(公告)号：US20070082929A1

    公开(公告)日：2007-04-12

    申请号：US11544407

    申请日：2006-10-04

    申请人： Thomas Gant ,  Sepehr Sarshar

    发明人： Thomas Gant ,  Sepehr Sarshar

    IPC分类号： A61K31/4439 ,  C07D403/02

    CPC分类号： C07D401/12

    摘要： Chemical syntheses and medical uses of novel inhibitors of the gastric H+, K+-ATPase for the treatment and/or management of duodenal ulcers, heartburn, acid reflux, other conditions mediated by gastric acid secretion and/or psoriasis are described.

    摘要翻译： 用于治疗和/或治疗十二指肠溃疡，胃灼热，酸反流，其他条件的胃H +，K + + ATP酶的新型抑制剂的化学合成和医学用途 由胃酸分泌和/或牛皮癣介导。

    SUBSTITUTED ARYLOXYPROPYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY
    3.
    发明申请
    SUBSTITUTED ARYLOXYPROPYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY 审中-公开
    具有丝氨酸和/或非诺贝宁活性的取代的芳基丙烯酰胺

    公开(公告)号：US20070155820A1

    公开(公告)日：2007-07-05

    申请号：US11562890

    申请日：2006-11-22

    申请人： Thomas Gant ,  Sepehr Sarshar

    发明人： Thomas Gant ,  Sepehr Sarshar

    IPC分类号： A61K31/381 ,  A61K31/138 ,  C07D333/22 ,  C07C217/30

    CPC分类号： C07D333/20 ,  C07B59/001 ,  C07B59/002 ,  C07B2200/07 ,  C07C217/48 ,  C07D333/24

    摘要： Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.

    摘要翻译： 用于治疗和/或治疗精神病症，焦虑障碍，广泛性焦虑症，抑郁症，创伤后应激障碍，强迫症的单胺神经递质及其药学上可接受的盐和前药的新型抑制剂的化学合成和医学用途， 强迫症，恐慌症，热潮红，老年痴呆，偏头痛，肝肺综合征，慢性疼痛，伤害性疼痛，神经性疼痛，疼痛性糖尿病性视网膜病变，双相抑郁症，阻塞性睡眠呼吸暂停，精神疾病，经前焦虑症，社交恐惧症，社交焦虑症 ，尿失禁，厌食症，神经性贪食症，肥胖症，局部缺血，头部损伤，脑细胞中的钙超载，药物依赖性和/或早泄。

    SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY
    4.
    发明申请
    SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY 有权
    具有丝氨酸和/或非诺贝宁活性的取代的苯乙烯

    公开(公告)号：US20070149622A1

    公开(公告)日：2007-06-28

    申请号：US11565451

    申请日：2006-11-30

    申请人： Thomas Gant ,  Sepehr Sarshar

    发明人： Thomas Gant ,  Sepehr Sarshar

    IPC分类号： A61K31/137

    CPC分类号： A61K31/137 ,  A61K45/06 ,  C07B59/001 ,  C07B2200/05 ,  C07C65/21 ,  C07C217/74 ,  C07C235/34 ,  C07C255/37 ,  C07C2601/14

    摘要： Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.

    摘要翻译： 用于治疗和/或治疗精神病症，焦虑障碍，广泛性焦虑症，抑郁症，创伤后应激障碍，强迫症的单胺神经递质及其药学上可接受的盐和前药的新型抑制剂的化学合成和医学用途， 强迫症，恐慌症，热潮红，老年痴呆，偏头痛，肝肺综合征，慢性疼痛，伤害性疼痛，神经性疼痛，疼痛性糖尿病性视网膜病变，双相抑郁症，阻塞性睡眠呼吸暂停，精神疾病，经前焦虑症，社交恐惧症，社交焦虑症 ，尿失禁，厌食症，神经性贪食症，肥胖症，局部缺血，头部损伤，脑细胞中的钙超载，药物依赖性和/或早泄。

    Preparation and utility of substituted amphetamines
    5.
    发明申请
    Preparation and utility of substituted amphetamines 审中-公开
    取代苯丙胺的制备和应用

    公开(公告)号：US20080045588A1

    公开(公告)日：2008-02-21

    申请号：US11890255

    申请日：2007-08-02

    申请人： Thomas Gant ,  Sepehr Sarshar

    发明人： Thomas Gant ,  Sepehr Sarshar

    IPC分类号： A61K31/357 ,  A61P25/00 ,  C07D317/46

    CPC分类号： C07D317/58

    摘要： Provided herein are substituted amphetamines, processes of preparation and pharmaceutical compositions thereof. Also provided are methods of their use for the treatment and/or management of trauma associated with a terminal disease, a post-traumatic-stress-disorder, or a psychological disorder.

    摘要翻译： 本文提供了取代的安非他明，制备方法及其药物组合物。 还提供了它们用于治疗和/或治疗与终末疾病，创伤后应激障碍或心理障碍相关的创伤的方法。

    Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties
    6.
    发明申请
    Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties 审中-公开
    取代的苯基哌啶与5-羟色胺能活性和增强的治疗性质

    公开(公告)号：US20070112031A1

    公开(公告)日：2007-05-17

    申请号：US11598572

    申请日：2006-11-13

    申请人： Thomas Gant ,  Sepehr Sarshar

    发明人： Thomas Gant ,  Sepehr Sarshar

    IPC分类号： A61K31/452 ,  C07D405/02

    CPC分类号： C07D405/12

    摘要： Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.

    摘要翻译： 用于治疗和/或治疗精神病症，焦虑障碍，广泛性焦虑症，抑郁症，创伤后应激障碍，强迫症的单胺神经递质及其药学上可接受的盐和前药的新型抑制剂的化学合成和医学用途， 强迫症，恐慌症，热潮红，老年痴呆，偏头痛，肝肺综合征，慢性疼痛，伤害性疼痛，神经性疼痛，疼痛性糖尿病性视网膜病变，双相抑郁症，阻塞性睡眠呼吸暂停，精神疾病，经前焦虑症，社交恐惧症，社交焦虑症 ，尿失禁，厌食症，神经性贪食症，肥胖症，局部缺血，头部损伤，脑细胞中的钙超载，药物依赖性和/或早泄。