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公开(公告)号:US20090069400A1
公开(公告)日:2009-03-12
申请号:US12160460
申请日:2007-01-17
申请人: Thomas John Bleisch , Christian Alexander Clarke , Jeffrey Alan Dodge , Scott Alan Jones , Jose Eduardo Lopez , Charles Willis Lugar, III , Brian Stephen Muehl , Timothy Ivo Richardson , Ying Kwong Yee , Kuo-Long Yu
发明人: Thomas John Bleisch , Christian Alexander Clarke , Jeffrey Alan Dodge , Scott Alan Jones , Jose Eduardo Lopez , Charles Willis Lugar, III , Brian Stephen Muehl , Timothy Ivo Richardson , Ying Kwong Yee , Kuo-Long Yu
IPC分类号: A61K31/404 , C07D209/14
CPC分类号: C07D209/10 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/24 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要: Compounds of Formula (I), wherein n is 1 or 2, and R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein, their preparation, pharmaceutical compositions, and methods of use are disclosed.
摘要翻译: 其中n为1或2,R 1,R 2,R 3,R 4,R 5,R 6,R 7和R 8如本文所定义的式(I)化合物,其制备,药物组合物和使用方法公开。
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公开(公告)号:US06992097B2
公开(公告)日:2006-01-31
申请号:US10453833
申请日:2003-06-03
申请人: Kenneth Lee Hauser , Jeffrey Alan Dodge , Mark Louis Heiman , Scott Alan Jones , Charles Arthur Alt , Henry Uhlman Bryant , Jeffrey Daniel Cohen , James Densmore Copp , Kennan Joseph Fahey , William Harlan Gritton , Louis Nickolaus Jungheim , Joseph Henry Kennedy , Charles Willis Lugar, III , Brian Stephen Muehl , Alan David Palkowitz , Andrew Michael Ratz , Gary Anthony Rhodes , Roger Lewis Robey , David Edward Seyler , Timothy Alan Shepherd , Kenneth Jeff Thrasher , William George Trankle
发明人: Kenneth Lee Hauser , Jeffrey Alan Dodge , Mark Louis Heiman , Scott Alan Jones , Charles Arthur Alt , Henry Uhlman Bryant , Jeffrey Daniel Cohen , James Densmore Copp , Kennan Joseph Fahey , William Harlan Gritton , Louis Nickolaus Jungheim , Joseph Henry Kennedy , Charles Willis Lugar, III , Brian Stephen Muehl , Alan David Palkowitz , Andrew Michael Ratz , Gary Anthony Rhodes , Roger Lewis Robey , David Edward Seyler , Timothy Alan Shepherd , Kenneth Jeff Thrasher , William George Trankle
IPC分类号: A61K31/415 , C07D233/44
CPC分类号: C07D207/416 , A61K45/06 , C07D207/16 , C07D207/42 , C07D231/40 , C07D233/88 , C07D401/06 , C07D403/06 , C07D403/12 , C07D409/12 , C07D417/06 , C07D487/08
摘要: This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
摘要翻译: 本发明涉及可用于调节哺乳动物内源性生长激素水平的新化合物。 本发明还涉及用于合成所述化合物的新中间体,以及在这些合成中使用的新方法。 还包括治疗哺乳动物的方法,其包括施用所述化合物。
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公开(公告)号:US06639076B1
公开(公告)日:2003-10-28
申请号:US09762529
申请日:2001-04-17
申请人: Kenneth Lee Hauser , Jeffrey Alan Dodge , Mark Louis Heiman , Scott Alan Jones , Charles Arthur Alt , Henry Uhlman Bryant , James Densmore Copp , William Harlan Gritton , Charles Willis Lugar, III , Brian Stephen Muehl , Alan David Palkowitz , Andrew Michael Ratz , Gary Anthony Rhodes , Roger Lewis Robey , Timothy Alan Shepherd , Kenneth Jeff Thrasher , William George Trankle
发明人: Kenneth Lee Hauser , Jeffrey Alan Dodge , Mark Louis Heiman , Scott Alan Jones , Charles Arthur Alt , Henry Uhlman Bryant , James Densmore Copp , William Harlan Gritton , Charles Willis Lugar, III , Brian Stephen Muehl , Alan David Palkowitz , Andrew Michael Ratz , Gary Anthony Rhodes , Roger Lewis Robey , Timothy Alan Shepherd , Kenneth Jeff Thrasher , William George Trankle
IPC分类号: C07D40112
CPC分类号: C07D207/416 , A61K45/06 , C07D207/16 , C07D207/42 , C07D231/40 , C07D233/88 , C07D401/06 , C07D403/06 , C07D403/12 , C07D409/12 , C07D417/06 , C07D487/08
摘要: This invention relates to novel compounds of formula I wherein A, B, D, E, G, J, L, X, V are as defined in the specification, and the compounds are useful in the modulation of endogenous growth hormone levels in a mammal.
摘要翻译: 本发明涉及式I的新化合物,其中A,B,D,E,G,J,L,X,V如说明书中所定义,并且该化合物可用于调节哺乳动物内源性生长激素水平。
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4.Selective estrogen receptor modulator for the treatment of osteoarthritis 失效
标题翻译: 选择性雌激素受体调节剂治疗骨关节炎公开(公告)号:US08476300B2
公开(公告)日:2013-07-02
申请号:US13062272
申请日:2009-09-03
申请人: Jeffrey Alan Dodge , Timothy Ivo Richardson , Christian Alexander Clarke , Scott Alan Jones , Ronald Jay Hinklin , Conrad Wilson Hummel , George Sal Lewis
发明人: Jeffrey Alan Dodge , Timothy Ivo Richardson , Christian Alexander Clarke , Scott Alan Jones , Ronald Jay Hinklin , Conrad Wilson Hummel , George Sal Lewis
IPC分类号: A61K31/4453 , C07D211/06
CPC分类号: C07D333/08 , C07D333/22 , C07D333/28 , C07D333/34 , C07D333/38
摘要: The present invention is directed to a compound of the formula (A): or a pharmaceutically acceptable salt thereof; and also to compounds of formula (I): or a pharmaceutically acceptable salt thereof.
摘要翻译: 本发明涉及式(A)的化合物或其药学上可接受的盐; 以及式(I)化合物或其药学上可接受的盐。
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5.Selective Estrogen Receptor Modulator for the Treatment of Osteoarthritis 失效
标题翻译: 选择性雌激素受体调节剂治疗骨关节炎公开(公告)号:US20110166182A1
公开(公告)日:2011-07-07
申请号:US13062272
申请日:2009-09-03
申请人: Jeffrey Alan Dodge , Timothy Ivo Richardson , Christian Alexander Clarke , Scott Alan Jones , Ronald Jay Hinklin , Conrad Wilson Hummel , George Sal Lewis
发明人: Jeffrey Alan Dodge , Timothy Ivo Richardson , Christian Alexander Clarke , Scott Alan Jones , Ronald Jay Hinklin , Conrad Wilson Hummel , George Sal Lewis
IPC分类号: A61K31/4535 , C07D409/12 , A61P19/02
CPC分类号: C07D333/08 , C07D333/22 , C07D333/28 , C07D333/34 , C07D333/38
摘要: The present invention is directed to a compound of the formula (A): or a pharmaceutically acceptable salt thereof; and also to compounds of formula (I): or a pharmaceutically acceptable salt thereof.
摘要翻译: 本发明涉及式(A)的化合物或其药学上可接受的盐; 以及式(I)化合物或其药学上可接受的盐。
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6.SELECTIVE ESTROGEN RECEPTOR MODULATORS CONTAINING A PHENYLSULFONYL GROUP 失效
标题翻译: 选择性雌激素受体调节剂含有苯磺酰胺类公开(公告)号:US20080214612A1
公开(公告)日:2008-09-04
申请号:US12100093
申请日:2008-04-09
申请人: Robert Dean Dally , Jeffrey Alan Dodge , Scott Alan Frank , Scott Alan Jones , Timothy Alan Shepherd , Owen Brendan Wallace , Kin Chlu Fong , Conrad Wilson Hummel , George Sal Lewis
发明人: Robert Dean Dally , Jeffrey Alan Dodge , Scott Alan Frank , Scott Alan Jones , Timothy Alan Shepherd , Owen Brendan Wallace , Kin Chlu Fong , Conrad Wilson Hummel , George Sal Lewis
IPC分类号: A61K31/445 , C07D295/08 , A61P35/00 , C07D295/14
CPC分类号: C07D295/088 , C07D295/13 , C07D333/56 , C07D333/64 , C07D333/72 , C07D409/02
摘要: The present invention relates to a selective estrogen receptor modulator of formula I or a pharmaceutical acid addition salt thereof; useful, e.g., for treating endometriosis and/or uterine leiomyoma/leiomyomata.
摘要翻译: 本发明涉及式I的选择性雌激素受体调节剂或其药用酸加成盐; 有用的,例如用于治疗子宫内膜异位症和/或子宫平滑肌瘤/平滑肌瘤。
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7.Selective estrogen receptor modulators containing a phenylsulfonyl group 失效
标题翻译: 含有苯磺酰基的选择性雌激素受体调节剂公开(公告)号:US07585977B2
公开(公告)日:2009-09-08
申请号:US12100093
申请日:2008-04-09
申请人: Robert Dean Dally , Jeffrey Alan Dodge , Scott Alan Frank , Scott Alan Jones , Timothy Alan Shepherd , Owen Brendan Wallace , Kin Chlu Fong , Conrad Wilson Hummel , George Sal Lewis
发明人: Robert Dean Dally , Jeffrey Alan Dodge , Scott Alan Frank , Scott Alan Jones , Timothy Alan Shepherd , Owen Brendan Wallace , Kin Chlu Fong , Conrad Wilson Hummel , George Sal Lewis
IPC分类号: C07D211/06
CPC分类号: C07D295/088 , C07D295/13 , C07D333/56 , C07D333/64 , C07D333/72 , C07D409/02
摘要: The present invention relates to a selective estrogen receptor modulator of formula I or a pharmaceutical acid addition salt thereof; useful, e.g., for treating endometriosis and/or uterine leiomyoma/leiomyomata.
摘要翻译: 本发明涉及式I的选择性雌激素受体调节剂或其药用酸加成盐; 有用的,例如用于治疗子宫内膜异位症和/或子宫平滑肌瘤/平滑肌瘤。
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